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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Abstract
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 ± 11.9 years [mean ± SD]) than in 137 women (53.2 ± 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast, high levels of plasma adiponectin were found in castrated mice. Testosterone treatment reduced plasma adiponectin concentration in both sham-operated and castrated mice. In 3T3-L1 adipocytes, testosterone reduced adiponectin secretion into the culture media, using pulse-chase study. Castration-induced increase in plasma adiponectin was associated with a significant improvement of insulin sensitivity. Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.
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“The two major adipokines, leptin and adiponectin, are characterized by higher circulating levels in women than men [14, 15].”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [15]
In the citing paper
“Testosterone has been reported to regulate the secretion of metabolic factors such as adiponectin 240 and leptin. 241”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [240]
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Items 201–300 of 833
Metabolic syndrome and polycystic ovary syndrome... and vice versa
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“In addition, androgens decrease plasma adiponectin concentrations (38,39), and weight loss results in a decrease in circulating androgens (40).”
BackgroundAdipose expression of adipocytokines in women with polycystic ovary syndrome
Svendsen, P. F., Christiansen, M., Hedley, P. L., Nilas, L., Pedersen, S. B., & Madsbad, S. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.03.056 · Cited by 67
“A significant although unexplained gender-specific difference in circulating adiponectin has been reported (47), and also a decrease in plasma adiponectin in parallel with progressing puberty in males has been reported (48), indicating a role for testosterone in the regulation of adiponectin.”
BackgroundEffect of adiposity on tissue-specific adiponectin secretion
Reneau, J. A., Goldblatt, M. I., Gould, J. C., Kindel, T. L., Kastenmeier, A. S., Higgins, R. M., Rengel, L. R., Schoyer, K. D., James, R. G., Obi, B., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198889 · Cited by 70
Moran, L. J., Noakes, M., Clifton, P. M., Wittert, G. A., Belobrajdic, D. P., & Norman, R. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2336 · Cited by 66
“However, there is a proposed role for androgens in inhibiting adiponectin expression and secretion (48) and IL-6 and TNF- in altering follicular function or gonadotropin secretion (15).”
BackgroundEffect of postmenopause and hormone replacement therapy on serum adiponectin levels
Siemińśka, L., Wojciechowska, C., Niedziolka, D., Marek, B., Kos‐Kudła, B., Kajdaniuk, D., & Nowak, M. (2005) · Metabolism · doi:10.1016/j.metabol.2005.06.008 · Cited by 65
“Higher concentrations of adiponectin in women than in men of comparable age and BMI [8,10,11] suggest that estrogens might have a stimulatory impact on production of adiponectin by adipocytes.”
BackgroundResultInfluentialAdiponectin and Adiponectin Receptors in Atherosclerosis
Gianopoulos, I., Mantzoros, C. S., & Daskalopoulou, S. S. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae021 · Cited by 76
Goralski, K. B., & Sinal, C. J. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-092 · Cited by 66
“One study demonstrated a direct effect of testosterone to inhibit adiponectin secretion from adipocytes and that castration of adult male mice increased plasma adiponectin levels (Nishizawa et al. 2002).”
BackgroundBianco, A., Mazzarella, G., Turchiarelli, V., Nigro, E., Corbi, G., Scudiero, O., Sofia, M., & Daniele, A. (2013) · Nutrients · doi:10.3390/nu5104115 · Cited by 64
“Moreover, postmenopausal women have higher proportions of HMW than premenopausal women, with a negative association of circulating concentrations of total and HMW adiponectin with sex steroids [41,42].”
BackgroundAdiponectin and cardiovascular inflammatory responses
Takemura, Y., Walsh, K. X., & Ouchi, N. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0025-4 · Cited by 63
“Testosterone-treatment decreases secretion of adiponectin by 3T3-L1 adipocytes and lowers plasma adiponectin levels in mice [ 32 ].”
BackgroundBlood ghrelin, resistin, and adiponectin concentrations during the normal menstrual cycle
Dafopoulos, K. C., Sourlas, D., Kallitsaris, A., Pournaras, S., & Messinis, I. E. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.07.1773 · Cited by 64
Nickelson, K. J., Stromsdorfer, K. L., Pickering, R. T., Liu, T., Ortinau, L. C., Keating, A. F., & Perfield, J. W. (2012) · Experimental Diabetes Research · doi:10.1155/2012/859395 · Cited by 69
“[30, 31] and while this appears to occur independent of estradiol levels, adiponectin is associated with improved insulin sensitivity and suggests a potential mechanism for our observed improvement in the females.”
BackgroundLower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectin
Buemann, B., Sørensen, T. I. A., Pedersen, O. B., Black, E., Holst, J. J., Toubro, S., Echwald, S. M., Holst, J. J., Rasmussen, C. E., & Astrup, A. V. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802929 · Cited by 64
Zhang, H., Yang, J., Zhang, M., Liu, C., Xu, M., Li, X., Yang, S.-Y., & Li, X.-Y. (2010) · Endocrine · doi:10.1007/s12020-010-9382-9 · Cited by 63
“It was reported that serum adiponectin levels were down-regulated by androgen [23, 24], which could be a risk for insulin resistance and atherosclerosis [25].”
BackgroundAroda, V. R., Ciaraldi, T. P., Chang, S., Dahan, M. H., Chang, R. J., & Henry, R. R. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.04.046 · Cited by 63
“Both in vitro and in vivo studies have demonstrated that T treatment can suppress adiponectin release (39), which suggests that elevated T levels in subjects with PCOS may contribute to lower circulating adiponectin levels in these individuals.”
BackgroundAdachi, T., Inoue, M., Hara, H., Maehata, E., & Suzuki, S. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810413 · Cited by 63
“The plasma adiponectin level was lower in males than in females, consistent with a previous report (Nishizawa et al. 2002), whereas there were no significant gender differences in FPG, HbA1c, immunoreactive insulin (IRI), body-mass index (BMI) and HOMA-R, as shown in Table 1.”
ResultAdiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study
Patel, D. A., Srinivasan, S. R., Xu, J.-H., Chen, W., & Berenson, G. S. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.028 · Cited by 62
Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications
Lau, E. S., Binek, A., Parker, S. J., Shah, S. H., Zanni, M. V., Eyk, J. E. V., & Ho, J. E. (2022) · Circulation Research · doi:10.1161/circresaha.121.319916 · Cited by 62
Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation
Gasparini, S. J., Swarbrick, M. M., Kim, S., Thai, L. J., Henneicke, H., Cavanagh, L. L., Tu, J., Weber, M.-C., Zhou, H., & Seibel, M. J. (2019) · Diabetologia · doi:10.1007/s00125-019-4887-0 · Cited by 64
Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults
Im, J., Kim, S.-H., Lee, J., Shim, J., Lee, H.-R., & Lee, D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.027 · Cited by 61
“However, Nishizawa et al [18] and Ryan et al [22] have suggested that adiponectin concentrations may not differ by age.”
BackgroundInfluentialAdipokines: New Emerging Roles in Fertility and Reproduction
Tersigni, C., Nicuolo, F. D., D’Ippolito, S., Veglia, M., Castellucci, M., & Simone, N. D. (2011) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318217b0a4 · Cited by 64
“A role for adiponectin in ovarian steroidogenesis is yet to be described but an interaction is likely, given the negative effects of testosterone on circulating adiponectin in human beings(83,84) and mice.(85) The role of resistin in women’s fertility is to be determined further, and presently most studies in this fie…”
BackgroundTestosterone a key factor in gender related metabolic syndrome
Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 65
“Low adiponectin level is associated with a greater incidence of CVD and type-2 diabetes in men (69,70).”
BackgroundIbáñez, L., Valls, C., Cabré, S., & de Zegher, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0047 · Cited by 61
Heilmann‐Heimbach, S., Hochfeld, L. M., Henne, S. K., & Nöthen, M. M. (2020) · Experimental Dermatology · doi:10.1111/exd.14130 · Cited by 60
Gender difference on the development of metabolic syndrome: a population-based study in Taiwan
Hwang, L., Bai, C., Chen, C., & Chien, K. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9183-5 · Cited by 60
“Greater visceral fat accumulation and lower plasma adiponectin concentrations in men than women are candidates for mediating gender differences in insulin sensitivity and higher vulnerability to CVD [ 27 , 28].”
BackgroundThe Impact of Nandrolone Decanoate on the Central Nervous System
Busardò, F. P., Frati, P., Mariantonia, D. S., Napoletano, S., Pinchi, E., Zaami, S., & Fineschi, V. (2014) · Current Neuropharmacology · doi:10.2174/1570159x13666141210225822 · Cited by 61
“Indeed, nandrolone may reduce adiponectin via a direct effect on the adipocyte, as indicated by cell culture experiments [76].”
The Emerging Role of Adiponectin in Female Malignancies
Gelsomino, L., Naimo, G. D., Catalano, S., Mauro, L., & Andò, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092127 · Cited by 60
“Some reports have widely demonstrated that the different estrogens/androgens production may influence adiponectin expression [50,51].”
BackgroundKojima, S., Funahashi, T., Otsuka, F., Maruyoshi, H., Yamashita, T., Kajiwara, I., Shimomura, H., Miyao, Y., Fujimoto, K., Sugiyama, S., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.07.028 · Cited by 59
Self-citationRelationship of Plasma Adiponectin With Sex Hormone and Insulin‐like Growth Factor Levels
Tworoger, S. S., Mantzoros, C. S., & Hankinson, S. E. (2007) · Obesity · doi:10.1038/oby.2007.263 · Cited by 59
“However, experimental studies have suggested that testosterone decreases adiponectin levels (41,54), whereas DHEA increases levels (55).”
BackgroundResultGender Differences in Adipocyte Metabolism and Liver Cancer Progression
Cheung, O. K.-W., & Cheng, A. S. L. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00168 · Cited by 62
“Androgen was shown to have a suppressive effect in adiponectin level consistently in cell lines, animal models, and human epidemiological studies (Nishizawa et al., 2002; Lanfranco et al., 2004; Isobe et al., 2005; Page et al., 2005).”
BackgroundResultMeta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome
Liu, Z., Liang, S., Que, S., Zhou, L., Zheng, S., & Mardinoğlu, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01238 · Cited by 61
“Androgens modulate the ADPQ level by inhibiting its secretion from adipocytes to the circulation, and testosteronerelated hypoadiponectinemia might contribute to specific severe insulin resistance in men (Nishizawa et al., 2002; Xu et al., 2005; Kadowaki et al., 2006).”
BackgroundAdiponectin and Metabolic Syndrome in Middle‐aged and Elderly Chinese
Wang, J., Li, H., Franco, O. H., Yu, Z., Liu, Y., & Xu, L. (2008) · Obesity · doi:10.1038/oby.2007.42 · Cited by 59
“Nevertheless, adiponectin levels varied depending on gender (9), age (10), and ethnic background (11), and it is therefore necessary to clarify its threshold for increased disease risk in specific groups before it can be considered in clinical practice.”
BackgroundResultMorán-Costoya, A., Proenza, A. M., Gianotti, M., Lladó, I., & Valle, A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0044 · Cited by 58
Serum Adiponectin Is Reduced in Acromegaly and Normalized after Correction of Growth Hormone Excess
Lam, K. S. L., Xu, A., Tan, K. C. B., Wong, L. S. L., Tiu, S.-C., & Tam, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032023 · Cited by 58
The role of adiponectin in obesity-associated female-specific carcinogenesis
Nagaraju, G. P., Rajitha, B., Aliya, S., Kotipatruni, R. P., Santharam, M. A., Hammond, A. L., Park, D., Chigurupati, S., Alam, A., & Pattnaik, S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.03.014 · Cited by 58
Higashiura, K., Ura, N., Ohata, J., Togashi, N., Takagi, S., Saitoh, S., Murakami, H., Takagawa, Y., & Shimamoto, K. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02165.x · Cited by 56
“As mentioned earlier, Nishizawa et al. (2002) reported that plasma concentrations of adiponectin are lower in men than in women and that androgens decrease plasma adiponectin levels.”
BackgroundSimilar and Additive Effects of Ovariectomy and Diabetes on Insulin Resistance and Lipid Metabolism
Tawfik, S. H., Mahmoud, B. F., Saad, M. I., Shehata, M., Kamel, M. A. E.-N., & Helmy, M. H. (2015) · Biochemistry Research International · doi:10.1155/2015/567945 · Cited by 55
Almeda‐Valdés, P., Ramos, D. C., Mehta, R., Gomez-Perez, F. J., Cruz‐Bautista, I., Arellano‐Campos, O., Navarrete-López, M., & Aguilar-Salinas, C. A. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-26 · Cited by 57
“Consistent with the results of previous studies [7,9], total adiponectin and HMWA levels were higher in women than in men (total adiponectin 9.”
Ebert, T., Kralisch, S., Hoffmann, A., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., Stümvoll, M., Tönjes, A., & Faßhauer, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4349 · Cited by 57
“agreement with findings for other adipokines and hepatokines including adiponectin (30), leptin (31, 32), vaspin (7), and FGF21 (10).”
BackgroundResultVitamin E Supplementation and Plasma 8‐Isoprostane and Adiponectin in Overweight Subjects
Sutherland, W. H. F., Manning, P. J., Walker, R. J., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2007) · Obesity · doi:10.1038/oby.2007.546 · Cited by 56
“The lower levels in men seem to be due to a testosterone-induced decrease in adiponectin production (33,34).”
BackgroundRole of Estrogen Receptor‐α and −β in Regulating Leptin Expression in 3T3‐L1 Adipocytes
Yi, K. W., Shin, J., Seo, H. S., Lee, J. K., Oh, M., Kim, T., Saw, H. S., Kim, S., & Hur, J. (2008) · Obesity · doi:10.1038/oby.2008.389 · Cited by 56
Altınova, A. E., Törüner, F. B., Bukan, N. C., Yaşar, D. G., Aktürk, M., Çakır, N., & ARSLAN, M. (2007) · Endocrine Journal · doi:10.1507/endocrj.k06-021 · Cited by 56
Yasui, T., Tomita, J., Miyatani, Y., Yamada, M., Uemura, H., Irahara, M., Arai, M., Kojimahara, N., Okabe, R., Ishii, Y., et al. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.08.001 · Cited by 55
Cameron, K., Miwa, S., Walker, C., & von Zglinicki, T. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-3 · Cited by 58
“Furthermore, sexual dimorphism in adipokines that regulate insulin sensitivity such as resistin, leptin, adiponectin, retinol binding protein 4 (RBP4) and glucocorticoids has been shown [22-26].”
BackgroundCognuck, S. Q., Reis, W. L., Silva, M., Debarba, L. K., Mecawi, A. S., de Paula, F. J. A., Franci, C. R., Elias, L. L. K., & Antunes‐Rodrigues, J. (2020) · Physiological Reports · doi:10.14814/phy2.14597 · Cited by 55
“The high adiponectin level in older male rats could be due to decreased androgens with age (Isobe et al., 2005; Nishizawa et al., 2002; Rosario et al., 2009; Smith et al., 1992; Xu et al., 2005).”
BackgroundStrakovsky, R. S., Lezmi, S., Shkoda, I., Flaws, J. A., Helferich, W. G., & Pan, Y. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.05.012 · Cited by 54
“However, It has been shown that testosterone could actually decrease adiponectin secretion from 3T3-L1 adipocytes and mice (high molecular weight form) [56,57], and body fat and adiponectin are elevated in androgen receptor knockout mice [58].”
Biondi, G., Marrano, N., Borrelli, A., Rella, M., Palma, G., CALDERONI, I., Siciliano, E., Lops, P., Giorgino, F., & Natalicchio, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105522 · Cited by 58
Reciprocal association between visceral obesity and adiponectin: in healthy premenopausal women
Kwon, K., Jung, S. H., Choi, C., & Park, S. H. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.03.050 · Cited by 54
“Previous studies have suggested that sex steroids such as androgens and estrogens decrease plasma adiponectin concentrations [38].”
BackgroundResultLaughlin, G. A., Barrett-Connor, E. L., & May, S. J. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02624.x · Cited by 53
Role of Adiponectin in Insulin-Resistant Hypertension and Atherosclerosis
MURAKAMI, H., Ura, N., Furuhashi, M., Higashiura, K., Miura, T., & Shimamoto, K. (2003) · Hypertension Research · doi:10.1291/hypres.26.705 · Cited by 53
“(49) reported that the plasma concentration of adiponectin is lower in men than in women, but that there is no difference in the concentrations in premenopausal and postmenopausal women.”
BackgroundOkui, H., Hamasaki, S., Ishida, S., Kataoka, T., Orihara, K., Fukudome, T., Ogawa, M., Oketani, N., Saihara, K., Shinsato, T., et al. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.03.116 · Cited by 52
“Future study of larger populations that include separate analysis of men and women and subgroup analysis of menopausal status could improve the predictive value of these data, as plasma adiponectin concentrations are modulated by gender [41] and menopausal status [42].”
BackgroundObesidade e adipocinas inflamatórias: implicações práticas para a prescrição de exercício
do Prado, W. L., Lofrano‐Prado, M. C., Oyama, L. M., & Dâmaso, A. R. (2009) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922009000600012 · Cited by 62
Xia, F., Xu, X., Zhai, H., Meng, Y., Zhang, H., Du, S., Xu, H., Wu, H., & Lu, Y. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-106 · Cited by 52
“[21] who found that in rodents the serum testosterone level was inversely related to the serum adiponectin level, an insulin-sensitizing adipocyte-derived protein.”
BackgroundOrio, F., Palomba, S., Cascella, T., Biase, S. D., Labella, D., Russo, T., Savastano, S., Zullo, F., Colao, A. A. L., Vettor, R., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0109 · Cited by 52
Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood
Ohman-Hanson, R. A., Cree‐Green, M., Kelsey, M. M., Bessesen, D. H., Sharp, T. A., Pyle, L. L., Pereira, R. I., & Nadeau, K. J. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1137 · Cited by 52
Altered relationship between body fat and plasma adiponectin in end-stage renal disease
Shoji, T., Shinohara, K., Hatsuda, S., Kimoto, E., Fukumoto, S., Emoto, M., Tahara, H., Koyama, H., Ishimura, E., Miki, T., et al. (2005) · Metabolism · doi:10.1016/j.metabol.2004.09.012 · Cited by 52
“A recent study by Nishizawa et al [27] revealed that the sexrelated difference in adiponectin was due not to estrogen but to androgen and that testosterone decreased the secretion of adiponectin.”
BackgroundWakabayashi, S., & Aso, Y. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2392 · Cited by 52
“One possible explanation is that androgens, specifically testosterone, reduce serum adiponectin via effects in adipocytes (29).”
BackgroundExpression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats
Beylot, M., Pinteur, C., & Peroni, O. D. (2006) · Metabolism · doi:10.1016/j.metabol.2005.09.016 · Cited by 51
“There are sex differences in plasma levels of adiponectin, in rodents and in humans, with higher values in females than in males [29-31].”
BackgroundPlasma adiponectin elevation in elderly individuals with subsyndromal depression
Jeong, H., Min, B. J., Lim, S. K., Kim, T. H., Lee, J. J., Park, J. H., Lee, S. B., Han, J. W., Choi, S. H., Park, Y. J., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.11.002 · Cited by 51
“This gender dimorphism in the association of adiponectin with SSD may be attributed to gender differences in the modulation of circulating adiponectin by, for example, interactions between adiponectin and sex steroids (Nishizawa et al., 2002; Combs et al., 2003).”
Panidis, D. (2004) · Human Reproduction · doi:10.1093/humrep/deh336 · Cited by 51
Circulating Adiponectin Is Associated with Obesity and Serum Lipids in West Africans
Meilleur, K. G., Doumatey, A. P., Huang, H., Charles, B. A., Chen, G., Zhou, J., Shriner, D., Adeyemo, A., & Rotimi, C. N. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2765 · Cited by 51
Katsiki, N., Mikhailidis, D. P., Gotzamani‐Psarrakou, A., Yovos, J. G., & Karamitsos, D. T. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.553609 · Cited by 50
“Plasma adiponectin levels are higher in women compared with men, a finding possibly attributed to androgen-induced hypoadiponectinemia [54].”
BackgroundSerum adiponectin concentrations in relation to maternaland perinatal characteristics in newborns
Mantzoros, C. S., Petridou, E. T., Alexe, D., Skalkidou, A., Dessypris, N., Papathoma, E., Salvanos, H., Shetty, G., Gavrila, A., Kedikoglou, S., et al. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510741 · Cited by 51
“It remains unclear why the gender difference is absent at birth and perhaps the gender dimorphism of adiponectin levels develops later in life in response to sex steroids in the peripubertal period (12, 32, 33 ).”
BackgroundAn overview on androgen-mediated actions in skeletal muscle and adipose tissue
Rizk, J. G., Sahu, R., & Duteil, D. (2023) · Steroids · doi:10.1016/j.steroids.2023.109306 · Cited by 54
Predictors of Insulin Resistance in Patients With Obesity
Stȩpień, M., Stępień, A., Wlazeł, R. N., Paradowski, M. T., Rizzo, M., Banach, M., & Rysz, J. (2012) · Angiology · doi:10.1177/0003319712468291 · Cited by 50
Sharma, A., Mah, M., Ritchie, R. H., & Blasio, M. J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108008 · Cited by 52
Adiponectin and Leptin in Relation to Insulin Sensitivity
Soodini, G. R., & Hamdy, O. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.114 · Cited by 48
Sato, H., Sugai, H., Kurosaki, H., Ishikawa, M., Funaki, A., Kimura, Y., & Ueno, K. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00868 · Cited by 47
Acute testosterone deprivation reduces insulin sensitivity in men
Rubinow, K. B., Snyder, C. N., Amory, J. K., Hoofnagle, A. N., & Page, S. T. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04189.x · Cited by 48
Close association of hypoadiponectinemia with arteriosclerosis obliterans and ischemic heart disease
Kawano, T., Saito, T., Yasu, T., Saito, T., Nakamura, T., Namai, K., Tamemoto, H., Kawakami, M., Saito, M., & Ishikawa, S.-E. (2005) · Metabolism · doi:10.1016/j.metabol.2004.12.009 · Cited by 47
“The level is lower in men than in women [5].”
BackgroundSelf-citationEicosanoids and Adipokines in Breast Cancer: From Molecular Mechanisms to Clinical Considerations
Basu, S., Nachat, R., Caldefie‐Chezet, F., & Vasson, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4408 · Cited by 47
“Factors such as TNF-a , androgens, b -adrenergic agonists, glucocorticoids, and c-AMP analogs inhibit adiponectin gene expression and/or secretion (85, 97, 176, 258).”
Labisia pumila extract regulates body weight and adipokines in ovariectomized rats
Mansor, F., Nazaimoon, W. M. W., Gu, H. F., & Östenson, C. (2008) · Maturitas · doi:10.1016/j.maturitas.2008.10.004 · Cited by 47
Biomarkers in atrial fibrillation: an overview
Vilchez, J. A., Roldán, V., Hernández‐Romero, D., Valdés, M., Lip, G. Y. H., & Marín, F. R. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12304 · Cited by 47
AlSaleh, A. F. F., Sanders, T. A. B., & O’Dell, S. D. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003181 · Cited by 47
“The gender differences have been attributed primarily to the inhibitory effect of testosterone on adiponectin production established in vitro((92)).”
BackgroundComparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome
Thanakun, S., Watanabe, H., Thaweboon, S., & Izumi, Y. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-19 · Cited by 45
“The effect of sex hormones might explain this discrepancy, as it has been hypothesized that androgen inhibits adiponectin secretion [38].”
BackgroundRelationships between obesity and the clinical severity of psoriasis in Taiwan
Huang, Y., Yang, L., Hui, R., Chang, Y., Yang, Y., Yang, C., Chen, Y., Chung, W., Kuan, Y. Z., & Chiu, C. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03573.x · Cited by 47
Determinants of Serum Adiponectin in Persons with and without Type 1 Diabetes
Maahs, D. M., Ogden, L. G., Snell-Bergeon, J. K., Kinney, G. L., Wadwa, R. P., Hokanson, J. E., Dabelea, D., Kretowski, A., Eckel, R. H., & Rewers, M. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm125 · Cited by 46
Sawada, T., Shite, J., Shinke, T., Otake, H., Tanino, Y., Ogasawara, D., Kawamori, H., Kato, H., Miyoshi, N., Yoshino, N., et al. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.12.216 · Cited by 46
“In the present study, we focused on men because several studies have reported that gender-dependent differences in plasma adiponectin were found and androgen-induced hypoadiponectinemia are related to the high risk of atherosclerosis in men [12].”
BackgroundLindmark, S., Burén, J., & Eriksson, J. W. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02593.x · Cited by 45
Delaney, K. Z., & Santosa, S. (2022) · Obesity Reviews · doi:10.1111/obr.13393 · Cited by 50
“Androgens have been found to decrease adiponectin levels more so than estrogen.(133) However, adiponectin levels are more volatile in females than males (Table 6).”
BackgroundAntiandrogenic Contraceptives Increase Serum Adiponectin in Obese Polycystic Ovary Syndrome Patients
Luque‐Ramírez, M., Álvarez‐Blasco, F., & Escobar-Morreale, H. F. (2008) · Obesity · doi:10.1038/oby.2008.491 · Cited by 46
“In conceptual agreement, androgen receptors are present in preadipocytes and adipocytes, particularly in visceral adipose tissue, possibly influencing the distribution of body fat (22) and administration of testosterone decreases the secretion of adiponectin both in vitro (23) and in vivo (24).”
BackgroundTamakoshi, K., Yatsuya, H., Wada, K., Matsushita, K., Otsuka, R., Yang, P. O., Sugiura, K., Hotta, Y., Mitsuhashi, H., Takefuji, S., et al. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02687.x · Cited by 45
Li, H. L., Peng, W. H., Cui, S. T., Lei, H., Wei, Y. D., Li, W. M., & Xu, Y. W. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.236 · Cited by 44
“In agreement with previous studies (10, 28, 33, 34), we found both increased vaspin and adiponectin levels in female sub-groups, implicating a sexual dimorphism of circulating adipokine levels.”
ResultBuday, B., Pach, F. P., Literáti-Nagy, B., Vitai, M., Vecsei, Z., & Koranyi, L. I. (2013) · Bone · doi:10.1016/j.bone.2013.07.018 · Cited by 45
Analysis of Adiponectin Gene and Comparison of Its Expression in Two Different Pig Breeds
Daniele, A., Cammarata, R., Masullo, M., G, N., Finamore, F., D’Andrea, M., Pilla, F., & Oriani, G. (2008) · Obesity · doi:10.1038/oby.2008.275 · Cited by 44
Kieżun, M., Maleszka, A., Smolińska, N., Nitkiewicz, A., & Kamiński, T. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-18 · Cited by 45
“A similar relationship was observed in mice [41].”
BackgroundGender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome
Eglit, T., Lember, M., Ringmets, I., & Rajasalu, T. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0688 · Cited by 44
Adiponectin in a Native Canadian Population Experiencing Rapid Epidemiological Transition
Hanley, A. J., Connelly, P. W., Harris, S. B., & Zinman, B. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3219 · Cited by 42
“This observation has been reported previously in studies of human subjects (5,10,32–34) as well as in rodents (32,35).”
BackgroundMujumdar, P. P., Duerksen-Hughes, P. J., Firek, A. F., & Hessinger, D. A. (2011) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2011.554995 · Cited by 45
Regulation of adiponectin secretion by endothelin-1
Clarke, K. J., Zhong, Q., Schwartz, D. D., Coleman, E. S., Kemppainen, R. J., & Judd, R. L. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.015 · Cited by 42
“Androgens decrease plasma adiponectin and androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men (172).”
BackgroundKleiblová, P., Springer, D., & Haluzı́k, M. (2006) · Physiological Research · doi:10.33549/physiolres.930977 · Cited by 43
“…of both in vitro and experimental data that demonstrated significant influence of both androgens and estrogens on circulating adiponectin levels (Nishizawa et al. 2002, 2006 Adiponectin and Menstrual Cycle 665 Combs et al. 2003) One explanation for the negative results of our study may be…”
BackgroundAndréasson, A., Undén, A., Elofsson, S., & Brismar, K. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22279 · Cited by 42
“Low levels of adiponectin in men could be explained by the inhibitory effect of androgens on adiponectin as previous studies have suggested (Nishizawa et al., 2002), but the findings in this study could not support this idea as the sex difference in adiponectin levels was maintained after…”
ResultA cross-sectional study for glucose intolerance of myotonic dystrophy
Matsumura, T., Iwahashi, H., Funahashi, T., Takahashi, M. P., Saito, T., Yasui, K., Saito, T., Iyama, A., Toyooka, K., Fujimura, H., et al. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.08.037 · Cited by 41
Self-citationRecent Update on the Molecular Mechanisms of Gonadal Steroids Action in Adipose Tissue
Wawrzkiewicz–Jałowiecka, A., Lalik, A., & Soveral, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105226 · Cited by 46
“, men have lower adiponectin levels than women when matching BMI and age groups are compared [144].”
BackgroundAlsiö, J., Birgner, C., Björkblom, L., Isaksson, P., Bergström, L., Schiöth, H. B., & Lindblom, J. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00439.x · Cited by 40
Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles
Bersinger, N. A., Birkhäuser, M., & Wunder, D. M. (2006) · Gynecological Endocrinology · doi:10.1080/09537100600931316 · Cited by 39
“The inverse correlation between observed adiponectin and androgen levels [11] would be in line with its reduced concentration in women with PCOS.”
BackgroundDecreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism
Takahashi, M., Inomata, S., Okimura, Y., Iguchi, G., Fukuoka, H., Miyake, K., Koga, D., Akamatsu, S., Kasuga, M., & Takahashi, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0201 · Cited by 39
Khaldi, R. A., Al‐Mulla, F., Awadhi, S. A., Kapila, K., & Mojiminiyi, O. A. (2011) · Disease Markers · doi:10.1155/2011/832165 · Cited by 39
Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?
Calton, E. K., Miller, V. S., & Soares, M. J. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.1 · Cited by 39
Kato, M., Watabe, K., Hamasaki, T., Umeda, M., Furubayashi, A., Kinoshita, K., Kishida, O., Fujimoto, T., Yamada, A., Tsukamoto, Y., et al. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0453-3 · Cited by 38
“In the present study, serum adiponectin levels were significantly higher in women than in men, similar to previously reported findings [35].”
ResultSelf-citation
Metadata
- Authors
- Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., Nakamura, T., Tochino, Y., Funahashi, T., & Matsuzawa, Y.
- Affiliations
- The University of Osaka (JP)
- From the Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2734-2741
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2102610155
- Cited by
- 837
- References
- 44
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 7 · 2023: 32 · 2022: 19 · 2021: 28 · 2020: 25 · 2019: 32 · 2018: 34 · 2017: 24 · 2016: 21 · 2015: 41 · 2014: 46 · 2013: 43 · 2012: 51
- FWCI
- 28.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- adiponectin, androgens, testosterone, sex hormones, insulin sensitivity, insulin resistance, atherosclerosis, hypoadiponectinemia, ovariectomy, castration, adipocytes, 3T3-L1 adipocytes, sex differences, menopause
- MeSH terms
- Adult, Androgens, Animals, Female, Humans, Insulin, Male, Mice, Inbred C57BL, Mice, Inbred ICR, Middle Aged, Ovariectomy, Proteins, Sex Characteristics, Testosterone, 3T3 Cells, Adipocytes, Postmenopause, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin
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