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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Abstract
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 ± 11.9 years [mean ± SD]) than in 137 women (53.2 ± 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast, high levels of plasma adiponectin were found in castrated mice. Testosterone treatment reduced plasma adiponectin concentration in both sham-operated and castrated mice. In 3T3-L1 adipocytes, testosterone reduced adiponectin secretion into the culture media, using pulse-chase study. Castration-induced increase in plasma adiponectin was associated with a significant improvement of insulin sensitivity. Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.
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“The two major adipokines, leptin and adiponectin, are characterized by higher circulating levels in women than men [14, 15].”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [15]
In the citing paper
“Testosterone has been reported to regulate the secretion of metabolic factors such as adiponectin 240 and leptin. 241”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [240]
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“Furthermore, it has been suggested that androgens decrease insulin sensitivity by reducing adiponectin production (21, 33).”
BackgroundRecent topics related to testosterone deficiency syndrome in Japan
Tsujimura, A., & Nonomura, N. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.132 · Cited by 8
Sexual dimorphism of high molecular weight adiponectin in cord blood
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Low adiponectin levels in primary hypertriglyceridemic male patients
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Adiponectin in human cord blood: relation to fetal birth weight and gender
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Plasma Adiponectin Levels in Elderly Patients with Prediabetes
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Adiponectin, Non-Esterified Fatty Acids and Antiphospholipid Antibodies in Type II Diabetes Mellitus
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“Androgens decrease adipo nectin levels, and androgen-induced hypoadiponectinemia may be related to the high risk of insulin resistance and atherosclerosis in men (17).”
BackgroundEffects of heavy alcohol intake on lipoproteins, adiponectin and cardiovascular risk
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Hamann, T. V., Mørk, F. B., Jensen, A. K., Jørgensen, N. R., Heidemann, M., Schou, A. J., Mølgaard, C., Pociot, F., Wedderkopp, N., & Johannesen, J. (2022) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2022.2073911 · Cited by 7
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“…risk markers following feeding with high-fat or specific FA-rich diets (81, 82); lower circulating adiponectin, a trait which we confirmed in the present study (data not shown) (83); marked resistance to genetic modification that mitigates obesity or promotes adipose tissue browning (78, 84).”
Tuna, M. M., Dogan, B. A., Karakılıç, E., Arduç, A., Işık, S., Yılmaz, F. M., Topçuoğlu, C., Berker, D. S., & Güler, S. (2014) · PubMed · Cited by 7
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Prepubertal androgen signaling is required to establish male fat distribution
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“For example, adiponectin activity, which is inhibited by androgen signaling, improves glucose metabolism and is present at higher levels in female and ARdY mice compared with males (Figure S2E) (Nishizawa et al., 2002; Pajvani and Scherer, 2003).”
BackgroundLuo, S., Zhu, H., Huang, H.-F., & Ding, G. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02069-5 · Cited by 7
Basios, G., Trakakis, E., Chrelias, C., Panagopoulos, P. K., Vaggopoulos, V., Skarpas, P., Kassanos, D., Dimitriadis, G. K., & Hatziagelaki, E. E. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.975684 · Cited by 8
“Hypoadiponectinemia seems to be a primary characteristic in hyperinsulinemic conditions [14], while the administration of insulin-sensitizing agents, such as thiazolidinedions, leads to an”
BackgroundInsuficiência androgênica na mulher e potenciais riscos da reposição terapêutica
Leão, L. M. C. S. M., Duarte, M. P. C., & Farias, M. L. F. (2005) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302005000200006 · Cited by 7
The Relation of Serum Adiponectin and Resistin Concentrations with Metabolic Risk Factors
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“Nishizawa 등[19]은 성호르 몬이 아디포넥틴에 미치는 영향을 보고하였는데, 남성의 경 우 여성에 비해 혈중 아디포넥틴 농도가 감소해 있었고 androgen이 아디포넥틴의 감소를 유발하고 이로인해 남성 에서 당뇨병 및 심혈관질환이 여성에 비해 증가하는 이유중 의 하나로 설명하였다.”
Serum levels of selected adipocytokines in benign and malignant parotid gland tumor patients
Sowa, P., Misiołek, M., Orecka, B., Czecior, E., & Adamczyk-Sowa, M. H. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.004 · Cited by 7
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“…levels were not affected by testosterone in vitro or in vivo, suggesting that the hormonemay act on the secretory pathway, and not necessarily on the regulation of its nuclear production, but the exact dynamics of the androgens action in this setting remains unknown (Nishizawa et al., 2002).”
BackgroundInfluentialKimura, K., Miura, S., Iwata, A., Sugihara, M., Arimura, T., Nishikawa, H., Kawamura, A., & Saku, K. (2008) · Journal of Cardiology · doi:10.1016/j.jjcc.2008.08.012 · Cited by 7
Metadata
- Authors
- Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., Nakamura, T., Tochino, Y., Funahashi, T., & Matsuzawa, Y.
- Affiliations
- The University of Osaka (JP)
- From the Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2734-2741
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2102610155
- Cited by
- 837
- References
- 44
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 7 · 2023: 32 · 2022: 19 · 2021: 28 · 2020: 25 · 2019: 32 · 2018: 34 · 2017: 24 · 2016: 21 · 2015: 41 · 2014: 46 · 2013: 43 · 2012: 51
- FWCI
- 28.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- adiponectin, androgens, testosterone, sex hormones, insulin sensitivity, insulin resistance, atherosclerosis, hypoadiponectinemia, ovariectomy, castration, adipocytes, 3T3-L1 adipocytes, sex differences, menopause
- MeSH terms
- Adult, Androgens, Animals, Female, Humans, Insulin, Male, Mice, Inbred C57BL, Mice, Inbred ICR, Middle Aged, Ovariectomy, Proteins, Sex Characteristics, Testosterone, 3T3 Cells, Adipocytes, Postmenopause, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin
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