The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cognitive Ability and Brain Structure in Type 1 Diabetes
Open accessAbstract
Type 1 diabetes is associated with chronic hyperglycemia and exposure to intermittent severe hypoglycemia. The long-term cerebral effects of these consequences of diabetes are ill defined. In this study, the history of preceding severe hypoglycemia and the presence of background retinopathy were examined in relation to cognitive ability (neuropsychological test battery) and brain structure (magnetic resonance imaging) in a cross-sectional evaluation of 74 young people with type 1 diabetes. Participants differed by their severe hypoglycemia exposure and degree of diabetic retinopathy and none had previous neuropsychological pathology. Severe hypoglycemia did not influence cognitive ability or brain structure. Background diabetic retinopathy was associated with small focal white-matter hyperintensities in the basal ganglia (33.3 vs. 4.7%, after correction for age, P = 0.005) and significant cognitive disadvantage, affecting fluid intelligence (P = 0.008, Eta2 = 0.14), information processing (P = 0.001, Eta2 = 0.22), and attention and concentration ability (P = 0.03, Eta2 = 0.09). In conclusion, recurrent exposure to severe hypoglycemia alone in young people with type 1 diabetes had no detrimental impact on brain structure or function over the duration of diabetes examined. Chronic hyperglycemia (inferred by the presence of background diabetic retinopathy) may affect brain structure and function.
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Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
The Diabetes Control and Complications Trial Research Group* (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-4-199602150-00001 · Cited by 160
Strachan, M. W., Deary, I. J., Ewing, F. M., & Frier, B. M. (2000) · Diabetes Care · doi:10.2337/diacare.23.3.305 · Cited by 113
Self-citationChalmers, J., Risk, M. T. A., Kean, D. M., Grant, R., Ashworth, B., & Campbell, I. W. (1991) · Diabetes Care · doi:10.2337/diacare.14.10.922 · Cited by 93 · cited 1×
“severe [3]).”
Cited by
Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease
Doubal, F. N., MacLullich, A. M. J., Ferguson, K. J., Dennis, M. S., & Wardlaw, J. M. (2010) · Stroke · doi:10.1161/strokeaha.109.564914 · Cited by 904
Self-citationPerivascular spaces in the brain: anatomy, physiology and pathology
Wardlaw, J. M., Benveniste, H., Nedergaard, M., Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0312-z · Cited by 870
Self-citationThe Effects of Type 1 Diabetes on Cognitive Performance
Brands, A. M. A., Biessels, G. J., de Haan, E. H. F., Kappelle, L. J., & Kessels, R. P. C. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.726 · Cited by 738
Long-term effect of diabetes and its treatment on cognitive function
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa066397 · Cited by 646
The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function
Awad, N., Gagnon, M., & Messier, C. (2004) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490514875 · Cited by 551
Metadata
- Authors
- Ferguson, S. C., Blane, A., Perros, P., McCrimmon, R. J., Best, J. J. K., Wardlaw, J., Deary, I. J., & Frier, B. M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-01-01
- Volume
- 52
- Issue
- 1
- Pages
- 149-156
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2171242179
- Cited by
- 288
- References
- 4
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ferguson, S. C., Blane, A., Perros, P., McCrimmon, R. J., Best, J. J. K., Wardlaw, J., Deary, I. J., & Frier, B. M. (2003). Cognitive Ability and Brain Structure in Type 1 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.52.1.149
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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