The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Age-Dependent Changes in Metabolism, Contractile Function, and Ischemic Sensitivity in Hearts From db/db Mice
Abstract
Glucose and palmitate metabolism and contractile function were measured with ex vivo perfused working hearts from control (db/+) and diabetic (db/db) female mice at 6, 10–12, and 16–18 weeks of age. Palmitate oxidation was increased by 2.2-fold in 6-week-old db/db hearts and remained elevated in 10- to 12- and 16- to 18-week-old hearts. Carbohydrate oxidation was normal at 6 weeks but was reduced to 27 and 23% of control at 10–12 and 16–18 weeks, respectively. At 6 weeks, db/db hearts exhibited a slight reduction in mechanical function, whereas marked signs of dysfunction were evident at 10–12 and 16–18 weeks. Mechanical function after ischemia-reperfusion was examined in hearts from male mice; at 6 weeks, db/db hearts showed normal recovery, whereas at 12 weeks it was markedly reduced. Fatty acid oxidation was the predominant substrate used after reperfusion. Thus, diabetic db/db hearts exhibit signs of a progressive cardiomyopathy; increased fatty acid oxidation preceded reductions in carbohydrate oxidation. Postischemic recovery of function was reduced in db/db hearts, in parallel with age-dependent changes in normoxic contractile performance. Finally, peroxisome proliferator-activated receptor-α treatment (3 weeks) did not affect sensitivity to ischemia-reperfusion, even though carbohydrate oxidation was increased and palmitate oxidation was decreased.
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In the citing paper
“Thus isolated working hearts from db/db mice exhibit reduced recovery following ischemia and reperfusion after diabetes develops, but recovery is normal in the pre-diabetic stage (3).”
From Cardiac remodeling in obesity (2008) · cites this paper as [3]
In the citing paper
“Treatment with PPAR-γ or PPAR-α agonists while improving myocardial substrate utilization did not increase postischemic recovery in db/db hearts (3, 36), but acute treatment with high concentrations of glucose and insulin, which substantially increased glucose oxidation rates, increased postischemic recovery and cardiac efficiency (90).”
From Cardiac remodeling in obesity (2008) · cites this paper as [3]
Citations
Cites
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Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265
A novel mouse model of lipotoxic cardiomyopathy
Chiu, H.-C., Kovács, A., Ford, D. A., Hsu, F., Garcia, R. A., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 762
Regulation of energy substrate metabolism in the diabetic heart
Stanley, W. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00047-3 · Cited by 480
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
Belke, D. D., Larsen, T. S., Gibbs, E. M., & Severson, D. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1104 · Cited by 401
Self-citationCavaghan, M. K., Ehrmann, D. A., & Polonsky, K. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10761 · Cited by 363
Diabetes-Obesity Syndromes in Mice
Coleman, D. L. (1982) · Diabetes · doi:10.2337/diab.31.1.s1 · Cited by 354
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Cited by
Sorted by citations
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543
Leon, B. M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i13.1246 · Cited by 1,215
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Diabetic cardiomyopathy, causes and effects
Boudina, S., & Abel, E. D. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9131-7 · Cited by 737
Metadata
- Authors
- Aasum, E., Hafstad, A. D., Severson, D. L., & Larsen, T. S.
- Affiliations
- UiT The Arctic University of Norway (NO)
- University of Calgary (CA)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 434-441
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2150336836
- Cited by
- 280
- References
- 53
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 17 · 2014: 13 · 2013: 10 · 2012: 21
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Norges Forskningsråd
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- db/db mice, type 2 diabetes, diabetic cardiomyopathy, myocardial metabolism, palmitate oxidation, fatty acid oxidation, carbohydrate oxidation, cardiac contractile function, ischemia-reperfusion injury, age-related changes, PPARα
- MeSH terms
- Aging, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Heart, Hemodynamics, Insulin, Mice, Inbred C57BL, Mice, Mutant Strains, Myocardial Contraction, Myocardium, Organ Size, Oxidation-Reduction, Myocardial Ischemia, Carbohydrate Metabolism, Mice, In Vitro Techniques
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