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Cited by 118Cardiovascular Function and Risk FactorsCardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats

Wang, Peipei, Lloyd, Steven G., Zeng, Huadong, Bonen, Arend, Chatham, John C.·2005·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.00935.2004
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Abstract

The goal of this study was to determine whether changes in cardiac metabolism in Type 2 diabetes are associated with contractile dysfunction or impaired response to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats were isolated and perfused with glucose, lactate, pyruvate, and palmitate. The rates of glucose, lactate, pyruvate, and palmitate oxidation rates and glycolysis were determined during baseline perfusion and low-flow ischemia (LFI; 0.3 ml/min for 30 min) and after LFI and reperfusion. Under all conditions, ATP synthesis from palmitate was increased and synthesis from lactate was decreased in the ZDF group, whereas the contribution from glucose was unchanged. During baseline perfusion, the rate of glycolysis was lower in the ZDF group; however, during LFI and reperfusion, there were no differences between groups. Despite these metabolic shifts, there were no differences in oxygen consumption or ATP production rates between the groups under any perfusion conditions. Cardiac function was slightly depressed before LFI in the ZDF group, but during reperfusion, function was improved relative to the control group despite the increased dependence on fatty acids for energy production. These data suggest that in this model of diabetes, the shift from carbohydrates to fatty acids for oxidative energy production did not increase myocardial oxygen consumption and was not associated with impaired response to ischemia and reperfusion.

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Crossref · 10.1152/ajpheart.00935.2004

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  • In Langendorff-perfused hearts from fa/fa (Zucker) rats prior to the onset of diabetes, cardiac function is depressed; after the onset of diabetes, increased FA utilization and decreased glucose and lactate utilization are observed.

    “In Langendorff-perfused hearts from fa/fa (Zucker) rats prior to the onset of diabetes, cardiac function was also depressed (369), and in rats studied after the onset of diabetes, increased FA utilization and decreased glucose and lactate utilization were observed (370).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [370]

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Authors
Wang, P., Lloyd, S. G., Zeng, H., Bonen, A., & Chatham, J. C.
Affiliations
University of Alabama at Birmingham (US)
ORCID
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
2005-05
Volume
288
Issue
5
Pages
H2102-H2110
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.00935.2004
OpenAlex
W2128140020
Cited by
118
References
51
Citations by year
2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 1 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 5
FWCI
5.67
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • University of Alabama at Birmingham
  • National Heart, Lung, and Blood Institute (HL-48789, HL 67464, 5T32HL07703, T32HL007703, R01HL067464)
  • National Cancer Institute (CA-13 148, P30CA013148)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
myocardial metabolism, type 2 diabetes, Zucker diabetic fatty rats, substrate utilization, fatty acid oxidation, glucose oxidation, lactate oxidation, pyruvate oxidation, glycolysis, myocardial ischemia, reperfusion, contractile dysfunction, ATP production, myocardial oxygen consumption
MeSH terms
Animals, Carbon Isotopes, Diabetes Mellitus, Type 2, Energy Metabolism, Fatty Acids, Glucose, Male, Myocardial Contraction, Myocardium, Magnetic Resonance Spectroscopy, Obesity, Palmitates, Rats, Zucker, Myocardial Reperfusion Injury, Pyruvic Acid, Lactic Acid, Rats, In Vitro Techniques

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