Cited by 69Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

β‐cell mass in people with type 2 diabetes

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Cho, Jae‐Hyoung, Kim, Ji‐Won, Shin, Jeong‐Ah, Shin, Juyoung, Yoon, Kun‐Ho·2011·Journal of Diabetes Investigation

Abstract

The early occurrence of β‐cell dysfunction has been broadly recognized as a critical determinant of the development and progression of type 2 diabetes. β‐cell dysfunction might be induced by insufficient β‐cell mass, by a dysfunction of the β‐cells, or both. Whether or not β‐cell dysfunction constitutes a cause of reduced β‐cells or vice‐versa currently remains unclear. The results of some studies have measured the loss of β‐cells in type 2 diabetic patients at between 22 and 63% by planimetric measurements. Because β‐cell hypertrophy has been noted in type 2 diabetic patients, the loss of β‐cell number should prove more profound than what has thus far been reported. Furthermore, β‐cell volumes are reduced even in patients with impaired fasting glucose. Such defects in β‐cell mass are associated with increased apoptosis rather than insufficient replication or neogenesis of β‐cells. With these results, although they still require clarification, the peak β‐cell mass might be determined at quite an early stage of life, and then might decline progressively over time as the result of exposure to harmful environmental influences over one’s lifetime. In this review, we have summarized the relevant studies regarding β‐cell mass in patients with type 2 diabetes, and then presented a review of the various causes of β‐cell loss in adults. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00072.x, 2010)

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  1. [89]Marselli L, Sgroi DC, Thorne J, et al. Evidence of inflammatory markers in beta cells of type 2 diabetic subjects. Diabetologia 2007; 50: S178

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Authors
Cho, J., Kim, J., Shin, J., Shin, J., & Yoon, K.
Affiliations
The Catholic University of Korea Seoul St. Mary's Hospital (KR)
Corresponding author
Yoon, Kun‐Ho
Venue
Journal of Diabetes Investigation
Publisher
Wiley
Published
2010-11-22
Volume
2
Issue
1
Pages
6-17
ISSN
  • 2040-1116 (ISSN-L)
  • 2040-1124
OpenAlex
W2163505408
Cited by
69
References
109
Citations by year
2025: 6 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 3 · 2013: 3 · 2012: 1
FWCI
0.34
Type
journal article
Language
en
Open access
Locations
  • Journal of Diabetes Investigation (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
beta-cell mass, type 2 diabetes, beta-cell dysfunction, beta cell destruction, beta-cell apoptosis, beta-cell hypertrophy, beta-cell neogenesis, impaired fasting glucose, planimetry

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