Cited by 332Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

Clegg, Deborah J., Riedy, Christine A., Smith, Kathleen A. Blake, Benoit, Stephen C., Woods, Stephen C.·2003·Diabetes

DOI 10.2337/diabetes.52.3.682

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Abstract

The distribution of fat in the body differs between the male and female sexes and is associated with the relative secretion of the two “adiposity” hormones leptin and insulin. We now report that the brains of male and female rats are differentially sensitive to the catabolic actions of small doses of these two hormones. Leptin (1 or 3.5 μg/2 μl) or saline (2 μl) was administered into the third cerebral ventricle of age- and weight-matched male and female rats. Leptin significantly reduced food intake in female and male rats over 4 h; however, leptin reduced 24-h intake in female but not in male rats. When the same rats were administered insulin (1 or 4 mU/2 μl) or saline (2 μl), male but not female rats had a robust reduction in food intake over 24 h. Previous research demonstrates the melanocortins are a central mediator of the effects of both leptin and insulin. However, we found no sex differences in sensitivity to the melanocortin agonist MTII (0.01, 0.1, 0.3, and 1.0 nmol/2 μl). These results suggest that the sex differences in sensitivity to leptin and insulin at the doses that we injected occur upstream of the melanocortin receptors. Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently.

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“DIABETES, VOL. 52, MARCH 2003 683 D ow nloaded from http://diabetesjournals.org/diabetes/article-pdf/52/3/682/373103/db0303000682.pdf by guest on 04 M arch 2022 I3vt leptin reduces food intake and body weight to a greater extent in female than male rats (experiment 2).”
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Authors: Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C.
Affiliations: University of Cincinnati (US)
University of Washington (US)
ORCID: Clegg, Deborah J.
Riedy, Christine A.
Smith, Kathleen A. Blake
Woods, Stephen C.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-03-01
Volume: 52
Issue: 3
Pages: 682-687
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.3.682
OpenAlex: W2007895806
Cited by: 332
References: 42
Citations by year: 2026: 1 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 19 · 2020: 23 · 2019: 10 · 2018: 15 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 15 · 2013: 25 · 2012: 14
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: University of Cincinnati
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK17844, DK54080, R01DK054080, P01DK056863, DK-56863)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, insulin, sex differences, dietary intake, melanocortin peptides, melanotan II, melanocortin receptors, adiposity, rats
MeSH terms: alpha-MSH, Animals, Body Composition, Body Weight, Brain, Eating, Female, Injections, Intraventricular, Insulin, Male, Sex Characteristics, Receptors, Corticotropin, Rats, Long-Evans, Leptin, Receptors, Melanocortin, Rats

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Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

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