Cited by 332Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

Clegg, Deborah J., Riedy, Christine A., Smith, Kathleen A. Blake, Benoit, Stephen C., Woods, Stephen C.·2003·Diabetes

DOI 10.2337/diabetes.52.3.682

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Abstract

The distribution of fat in the body differs between the male and female sexes and is associated with the relative secretion of the two “adiposity” hormones leptin and insulin. We now report that the brains of male and female rats are differentially sensitive to the catabolic actions of small doses of these two hormones. Leptin (1 or 3.5 μg/2 μl) or saline (2 μl) was administered into the third cerebral ventricle of age- and weight-matched male and female rats. Leptin significantly reduced food intake in female and male rats over 4 h; however, leptin reduced 24-h intake in female but not in male rats. When the same rats were administered insulin (1 or 4 mU/2 μl) or saline (2 μl), male but not female rats had a robust reduction in food intake over 24 h. Previous research demonstrates the melanocortins are a central mediator of the effects of both leptin and insulin. However, we found no sex differences in sensitivity to the melanocortin agonist MTII (0.01, 0.1, 0.3, and 1.0 nmol/2 μl). These results suggest that the sex differences in sensitivity to leptin and insulin at the doses that we injected occur upstream of the melanocortin receptors. Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently.

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Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citation
Overweight and obesity in the United States: prevalence and trends, 1960–1994
Flegal, K., Carroll, M., Kuczmarski, R., & Johnson, C. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800541 · Cited by 3,045
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Leptin enters the brain by a saturable system independent of insulin
Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222
Signals That Regulate Food Intake and Energy Homeostasis
Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,177
Self-citation
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879
Self-citation
The Obesity Epidemic Is a Worldwide Phenomenon
Popkin, B. M., & Doak, C. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01722.x · Cited by 859
Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus
Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.10.5570 · Cited by 769 · cited 8×
“DIABETES, VOL. 52, MARCH 2003 683 D ow nloaded from http://diabetesjournals.org/diabetes/article-pdf/52/3/682/373103/db0303000682.pdf by guest on 04 M arch 2022 I3vt leptin reduces food intake and body weight to a greater extent in female than male rats (experiment 2).”
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Evidence for Central Regulation of Glucose Metabolism
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Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission
Kroll, D. S., Feldman, D. E., Biesecker, C. L., McPherson, K. L., Manza, P., Joseph, P. V., Volkow, N. D., & Wang, G. (2020) · Nutrients · doi:10.3390/nu12071942 · Cited by 63
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Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
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Central actions of insulin during pregnancy and lactation
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Shi, H., Sorrell, J. E., Clegg, D. J., Woods, S. C., & Seeley, R. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.018 · Cited by 55
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Chen, G. ‐., Li, Q., & Ye, J. ‐. (2013) · Obesity Reviews · doi:10.1111/obr.12088 · Cited by 52
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Rathod, Y. D., & Fulvio, M. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246569 · Cited by 50
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Thorn, S. R., Meyer, M. J., Amburgh, M. E. V., & Boisclair, Y. R. (2007) · Journal of Dairy Science · doi:10.3168/jds.2007-0009 · Cited by 42
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Abraham, M. A., Filippi, B., Kang, G. M., Kim, M., & Lam, T. K. T. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.079962 · Cited by 44
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Resistant starch: safe intakes and legal status.
Goldring, J. M. (2004) · PubMed · Cited by 40
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Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Delanoye, A., Verwaerde, C., Spriet, C., Saule, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040351 · Cited by 40
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Self-citation
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O’Connor, K. L., Scisco, J. L., Smith, T. J., Young, A., Montain, S. J., Price, L. L., Lieberman, H. R., & Karl, J. P. (2016) · Journal of Nutrition · doi:10.3945/jn.115.217976 · Cited by 36
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Aung, Z. K., Grattan, D. R., & Ladyman, S. R. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110933 · Cited by 57
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Khalyfa, A., Carreras, A., Almendros, I., Hakim, F., & Gozal, D. (2015) · SLEEP · doi:10.5665/sleep.4568 · Cited by 35
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The Central Insulin System and Energy Balance
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Self-citation
Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice
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Lieu, L., Chau, D., Afrin, S., Dong, Y., Alhadeff, A. L., Betley, J. N., & Williams, K. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113039 · Cited by 35
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Plut, C., Ribière, C., Giudicelli, Y., & Dausse, J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054726 · Cited by 33
Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight
Wagner, L., Veit, R., Fritsche, L., Häring, H., Fritsche, A., Birkenfeld, A. L., Heni, M., Preissl, H. T., & Kullmann, S. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01167-3 · Cited by 33
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Labad, J., Price, J. F., Strachan, M. W. J., Deary, I. J., Seckl, J. R., Sattar, N. A., & Reynolds, R. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.026 · Cited by 32
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Begg, D. P. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2014.12.007 · Cited by 31
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Woods, S. C., Benoit, S. C., & Clegg, D. J. (2006) · Diabetes · doi:10.2337/db06-s015 · Cited by 30
Self-citation
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Jessen, L., Clegg, D. J., & Bouman, S. D. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90736.2008 · Cited by 29
Self-citation
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Liu, H., Choi, J., & Yun, J. W. (2011) · PROTEOMICS · doi:10.1002/pmic.201100127 · Cited by 29
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Chakraborty, T. R., Tkalych, O., Nanno, D., Garcia, A. L., Devi, L. A., & Salton, S. R. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.124 · Cited by 29
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Thibault, L., Woods, S. C., & Westerterp‐Plantenga, M. S. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041141 · Cited by 27
Self-citation
Ac-Trp-DPhe(p-I)-Arg-Trp-NH2, a 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently
Lensing, C. J., Adank, D. N., Doering, S. R., Wilber, S. L., Andreasen, A. M., Schaub, J. W., Xiang, Z., & Haskell‐Luevano, C. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00156 · Cited by 26
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Massa, M. G., & Correa, S. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165840 · Cited by 27
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Dai, Y., Zhao, Y., Tomi, M., Shin, B., Thamotharan, S., Mazarati, A. M., Sankar, R., Wang, E. A., Cepeda, C., Levine, M. S., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1816 · Cited by 25
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Jacobsson, S., Larsson, P., Johansson, G., Norberg, M., Wadell, G., Hallmans, G., Winsö, O., & Söderberg, S. (2017) · Journal of Inflammation · doi:10.1186/s12950-017-0167-2 · Cited by 24
Interoceptive “satiety” signals produced by leptin and CCK
Kanoski, S. E., Walls, E. K., & Davidson, T. L. (2007) · Peptides · doi:10.1016/j.peptides.2007.02.015 · Cited by 24
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Yin, W., Maguire, S. M., Pham, B., Garcia, A. N., Dang, N.-V., Liang, J., Wolfe, A., Hofmann, H. A., & Gore, A. C. (2015) · Endocrinology · doi:10.1210/en.2015-1032 · Cited by 23
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Stefanidis, A., Wiedmann, N. M., Adler, E. S., & Oldfield, B. J. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.08.001 · Cited by 22
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Beetch, M., & Alejandro, E. U. (2021) · Children · doi:10.3390/children8110970 · Cited by 22
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Tan, S. Y., Lei, X., Little, H. C., Rodriguez, S., Sarver, D. C., Cao, X., & Wong, G. W. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00533.2019 · Cited by 22
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Contini, A., Sanna, F., Maccioni, P., Colombo, G., & Argiolas, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.004 · Cited by 24
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Sellayah, D., Sek, K. S., Anthony, F. W., Watkins, A. J., Osmond, C., Fleming, T. P., Hanson, M. A., & Cagampang, F. R. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.126 · Cited by 20
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Geary, N. (2004) · Physiology and Behavior · doi:10.1016/j.physbeh.2004.08.041 · Cited by 18
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Authors: Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C.
Affiliations: University of Cincinnati (US)
University of Washington (US)
ORCID: Clegg, Deborah J.
Riedy, Christine A.
Smith, Kathleen A. Blake
Woods, Stephen C.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-03-01
Volume: 52
Issue: 3
Pages: 682-687
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.3.682
OpenAlex: W2007895806
Cited by: 332
References: 42
Citations by year: 2026: 1 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 19 · 2020: 23 · 2019: 10 · 2018: 15 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 15 · 2013: 25 · 2012: 14
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: University of Cincinnati
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK17844, DK54080, R01DK054080, P01DK056863, DK-56863)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, insulin, sex differences, dietary intake, melanocortin peptides, melanotan II, melanocortin receptors, adiposity, rats
MeSH terms: alpha-MSH, Animals, Body Composition, Body Weight, Brain, Eating, Female, Injections, Intraventricular, Insulin, Male, Sex Characteristics, Receptors, Corticotropin, Rats, Long-Evans, Leptin, Receptors, Melanocortin, Rats

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Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

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