The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Abstract
The distribution of fat in the body differs between the male and female sexes and is associated with the relative secretion of the two “adiposity” hormones leptin and insulin. We now report that the brains of male and female rats are differentially sensitive to the catabolic actions of small doses of these two hormones. Leptin (1 or 3.5 μg/2 μl) or saline (2 μl) was administered into the third cerebral ventricle of age- and weight-matched male and female rats. Leptin significantly reduced food intake in female and male rats over 4 h; however, leptin reduced 24-h intake in female but not in male rats. When the same rats were administered insulin (1 or 4 mU/2 μl) or saline (2 μl), male but not female rats had a robust reduction in food intake over 24 h. Previous research demonstrates the melanocortins are a central mediator of the effects of both leptin and insulin. However, we found no sex differences in sensitivity to the melanocortin agonist MTII (0.01, 0.1, 0.3, and 1.0 nmol/2 μl). These results suggest that the sex differences in sensitivity to leptin and insulin at the doses that we injected occur upstream of the melanocortin receptors. Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently.
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In the citing paper
“Intracerebroventricular injection of insulin markedly reduced food intake in male rodents, whereas feeding was unaffected in female rodents23.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [23]
In the citing paper
“Of note, experimental studies suggest considerable sex differences in brain insulin sensitivity.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [23]
In the citing paper
“Male rats, however, are more sensitive to the anorectic action of insulin injected in the brain [32], an observation that translates to humans.”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [32]
In the citing paper
“Accordingly, female rats are more sensitive to the anorectic action of centrally injected leptin than males [32].”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [32]
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“Male rats, however, are more sensitive to the anorectic action of insulin injected in the brain [32], an observation that translates to humans.”
Background
Metadata
- Authors
- Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C.
- Affiliations
- University of Cincinnati (US)
- University of Washington (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-03-01
- Volume
- 52
- Issue
- 3
- Pages
- 682-687
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2007895806
- Cited by
- 332
- References
- 42
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 19 · 2020: 23 · 2019: 10 · 2018: 15 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 15 · 2013: 25 · 2012: 14
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Cincinnati
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK17844, DK54080, R01DK054080, P01DK056863, DK-56863)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, insulin, sex differences, dietary intake, melanocortin peptides, melanotan II, melanocortin receptors, adiposity, rats
- MeSH terms
- alpha-MSH, Animals, Body Composition, Body Weight, Brain, Eating, Female, Injections, Intraventricular, Insulin, Male, Sex Characteristics, Receptors, Corticotropin, Rats, Long-Evans, Leptin, Receptors, Melanocortin, Rats
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