The Insulin Resistance—Dyslipidemic Syndrome of Visceral Obesity: Effect on Patients' Risk
Open accessAbstract
Coronary heart disease (CHD) and type 2 diabetes mellitus represent two highly prevalent conditions in affluent societies. Although a dyslipidemic state is frequently found in type 2 patients with obesity, studies have shown that the high triglyceride, low high‐density lipoprotein (HDL) cholesterol dyslipidemia is also found in nondiabetic patients with insulin resistance. Studies that have used imaging techniques to assess the regional distribution of body fat have shown that an excess of visceral adipose tissue, that is, a high accumulation of fat in the abdominal cavity, was associated with a cluster of metabolic disturbances such as insulin resistance, hyperinsulinemia, glucose intolerance, hypertriglyceridemia, elevated apolipoprotein B (apoB) concentrations, small, dense low‐density lipoprotein (LDL) particles, as well as low HDL cholesterol levels. Prospective studies such as the Quebec Cardiovascular Study have shown that this cluster of metabolic abnormalities commonly found in patients with excess visceral adipose tissue substantially increases the risk of CHD. The high prevalence of visceral obesity in sedentary adult men and postmenopausal women is such that it may represent the most prevalent cause of atherogenic dyslipidemic states associated with CHD in our population.
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The commonly observed relationship between increased VAT and metabolic disease is because of the correlation between VAT and IHTG.
“and suggest the commonly observed relationship between increased VAT and metabolic disease (1-4) is because of the correlation between VAT and IHTG (8)(9)(10).”
From Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009) · cites this paper as [4]
An increase in VAT is associated with impaired glucose tolerance, insulin resistance, and increased VLDL-TG secretion.
“data from metabolic studies conducted on human subjects (3,4) indicate that an increase in VAT is associated with impaired glucose tolerance, insulin resistance, and increased very-low-density lipoproteintriglyceride (VLDL-TG) secretion.”
From Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009) · cites this paper as [4]
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Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
Pouliot, M.-C., Despres, J., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. (1994) · American Journal of Cardiology · doi:10.1016/0002-9149(94)90676-9 · Cited by 2,238 · see citing works
Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931 · see citing works
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699 · see citing works
Self-citationLapidus, L., Bengtsson, C., Larsson, B., Pennert, K. M., Rybo, E., & Sjöström, L. (1984) · BMJ · doi:10.1136/bmj.289.6454.1257 · Cited by 1,657 · see citing works
Manninen, V, Tenkanen, L., Koskinen, P., Huttunen, J. K., Mänttäri, M., Heinonen, O. P., & Frick, M. H. (1992) · Circulation · doi:10.1161/01.cir.85.1.37 · Cited by 1,329 · see citing works
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.
Després, J. P., Moorjani, S., Lupien, P. J., Tremblay, A., Nadeau, A., & Bouchard, C. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.4.497 · Cited by 1,248 · see citing works
Self-citationOhlson, L., Larsson, B., Svärdsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Björntorp, P., & Tibblin, G. (1985) · Diabetes · doi:10.2337/diab.34.10.1055 · Cited by 1,143 · see citing works
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132 · see citing works
Epidemiology of coronary heart disease: the Framingham study.
Castelli, W. (1984) · American Journal of Medicine · doi:10.1016/0002-9343(84)90952-5 · Cited by 1,106 · see citing works
Lamarche, B., Tchernof, A., Moorjani, S., Cantin, B., Dagenais, G. R., Lupien, P. J., & Despre´s, J.-P. (1997) · Circulation · doi:10.1161/01.cir.95.1.69 · Cited by 1,077 · see citing works
Assmann, G., & Schulte, H. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90550-i · Cited by 872 · see citing works
CENTRAL OBESITY AND CORONARY HEART DISEASE IN MEN
Donahue, R., & Abbott, R. D. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91357-2 · Cited by 819 · see citing works
Pyörälà, K. (1979) · Diabetes Care · doi:10.2337/diacare.2.2.131 · Cited by 775 · see citing works
Visceral Obesity in Men: Associations With Glucose Tolerance, Plasma Insulin, and Lipoprotein Levels
Pouliot, M., Després, J., Nadeau, A., Moorjani, S., Prud’homme, D., Lupien, P. J., Tremblay, A., & Bouchard, C. (1992) · Diabetes · doi:10.2337/diab.41.7.826 · Cited by 634 · see citing works
Self-citationBody Fat Distribution and 5-Year Risk of Death in Older Women
Folsom, A. R. (1993) · JAMA · doi:10.1001/jama.1993.03500040049035 · Cited by 611 · see citing works
Abdominal obesity as important component of insulin-resistance syndrome.
Després, J. (1994) · PubMed · Cited by 568 · see citing works
Self-citationSex differences in the relation of visceral adipose tissue accumulation to total body fatness
Lemieux, S., Prud’homme, D., Bouchard, C., Tremblay, A., & Després, J. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.463 · Cited by 561 · see citing works
Self-citationARE APOLIPOPROTEINS BETTER DISCRIMINATORS THAN LIPIDS FOR ATHEROSCLEROSIS?
Avogaro, P., Bon, G. B., Avogaro, P., Cazzolato, G., & Quinci, G. B. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91375-8 · Cited by 523 · see citing works
Lemieux, S., Prud'homme, D., Bouchard, C., Tremblay, A., & Despres, J. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.685 · Cited by 519 · see citing works
Lamarche, B., Moorjani, S., Lupien, P. J., Cantin, B., Bernard, P.-M., Dagenais, G. R., & Despre´s, J.-P. (1996) · Circulation · doi:10.1161/01.cir.94.3.273 · Cited by 476 · see citing works
Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause
Haarbo, J., Marslew, U., Gotfredsen, A., & Christiansen, C. (1991) · Metabolism · doi:10.1016/0026-0495(91)90037-w · Cited by 441 · see citing works
Bray, G. A. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-6-1052 · Cited by 384 · see citing works
Biology of regional body fat distribution: Relationship to non‐insulin‐dependent diabetes mellitus
Kissebah, A. H., & Peiris, A. N. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050202 · Cited by 384 · see citing works
Tchernof, A., Lamarche, B., Prud'homme, D., Nadeau, A., Moorjani, S., Labrie, F., Lupien, P. J., & Després, J.-P. (1996) · Diabetes Care · doi:10.2337/diacare.19.6.629 · Cited by 323 · see citing works
Self-citationKissebah, A. H., Freedman, D. S., & Peiris, A. N. (1989) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30695-2 · Cited by 314 · see citing works
Abdominal obesity and the development of noninsulin‐dependent diabetes mellitus
Björntorp, P. A. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040607 · Cited by 292 · see citing works
Després, J., & Lamarche, B. (1993) · Nutrition Research Reviews · doi:10.1079/nrr19930010 · Cited by 271 · see citing works
Self-citationVisceral Fat and Race-Dependent Health Risks in Obese Nondiabetic Premenopausal Women
Albu, J., Murphy, L. L., Frager, D. H., Johnson, J. A., & Pi-Sunyer, X. (1997) · Diabetes · doi:10.2337/diab.46.3.456 · Cited by 259 · see citing works
Visceral adipose tissue differences in black and white women
Conway, J., Yanovski, S. Z., Avila, N., & Hubbard, V. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.765 · Cited by 258 · see citing works
Obesity, Atherosclerosis, and Coronary Artery Disease
Barrett-Connor, E. L. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-6-1010 · Cited by 244 · see citing works
Rader, D. J., Hoeg, J. M., & Brewer, H. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-12-199406150-00008 · Cited by 225 · see citing works
Després, J. (1994) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80289-7 · Cited by 203 · see citing works
Self-citationEston, R. G. (1997) · British Journal of Sports Medicine · doi:10.1136/bjsm.31.4.353-c · Cited by 188 · see citing works
Després, J., Lemieux, S., Lamarche, B., homme, D. P., Moorjani, S., Brun, L., Gagné, C., & Lupien, P. J. (1995) · PubMed · Cited by 178 · see citing works
Self-citationLemieux, S., Despr�s, J.-P., Moorjani, S., Nadeau, A., riault, G. T., Prud’homme, D., Tremblay, A., Bouchard, C., & Lupien, P. J. (1994) · Diabetologia · doi:10.1007/bf00404332 · Cited by 171 · see citing works
Self-citationLamarche, B., Després, J., Moorjani, S., Cantin, B., Dagenais, G. R., & Lupien, P.-J. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80760-7 · Cited by 170 · see citing works
Self-citationKarter, A. J., Mayer‐Davis, E. J., Selby, J. V., D'Agostino, R. B., Haffner, S. M., Sholinsky, P. D., Bergman, R. N., Saad, M. F., & Hamman, R. F. (1996) · Diabetes · doi:10.2337/diab.45.11.1547 · Cited by 170 · see citing works
KERRY, R. J. (1964) · BMJ · doi:10.1136/bmj.1.5390.1108 · Cited by 157 · see citing works
Lemieux, S., Prud’homme, D., Nadeau, A., Tremblay, A., Bouchard, C., & Després, J. (1996) · Diabetes Care · doi:10.2337/diacare.19.9.983 · Cited by 126 · see citing works
Self-citationAnthropometric correlates to changes in visceral adipose tissue over 7 years in women.
Lemieux, S., homme, D. P., Tremblay, A., Bouchard, C., & Després, J. (1996) · PubMed · Cited by 123 · see citing works
Self-citationLong term follow up of untreated primary hyperparathyroidism.
Paterson, C. R., Burns, J., & Mowat, E. (1984) · BMJ · doi:10.1136/bmj.289.6454.1261 · Cited by 110 · see citing works
Terry, R. B., Page, W. F., & Haskell, W. L. (1992) · PubMed · Cited by 96 · see citing works
YARNELL, J. W. G., Sweetnam, P. M., Marks, V., Teale, J. D., & Bolton, C. (1994) · Heart · doi:10.1136/hrt.71.3.293 · Cited by 78 · see citing works
Ullmann, D., CONNOR, W. E., Hatcher, L. F., Connor, S. L., & Flavell, D. P. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.4.1059 · Cited by 75 · see citing works
Food carbohydrates and plasma lipids””an update
Truswell, A. S. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.3.710s · Cited by 74 · see citing works
Hazards in subgroups of human obesity
Björntorp, P. A. (1984) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1984.tb01174.x · Cited by 71 · see citing works
The Role of Lipoprotein A-I and Lipoprotein A-I/A-II in Predicting Coronary Artery Disease
O’Brien, T., Nguyen, T. T., Hallaway, B. J., Hodge, D. O., Bailey, K. R., Holmes, D. R., & Kottke, B. A. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.2.228 · Cited by 69 · see citing works
Lemieux, S. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05603-t · Cited by 64 · see citing works
Why can high insulin levels indicate a risk for coronary heart disease?
Fontbonne, A. (1994) · Diabetologia · doi:10.1007/bf00400954 · Cited by 62 · see citing works
Lipoprotein metabolism in visceral obesity.
Asayama, K., Okada, Y., & Kato, K. (1991) · PubMed · Cited by 56 · see citing works
Dagenais, G. R., Robitaille, N. M., Lupien, P. J., Christen, A., Gingras, S., Moorjani, S., Meyer, F., & Rochon, J. (1990) · PubMed · Cited by 49 · see citing works
Risk factors for ischaemic heart disease: is it time to measure insulin?
Després, J., Lamarche, B., Mauriège, P., Cantin, B., Lupien, P. J., & Dagenais, G. R. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014700 · Cited by 23 · see citing works
Self-citationCouillard, C., Lamarche, B., Tchernof, A., Prud’homme, D., Tremblay, A., Bouchard, C., Moorjanit, S., Nadeau, A., Lupien, P. J., & Després, J. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90164-x · Cited by 21 · see citing works
Self-citationSniderman, A. D. (1992) · PubMed · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Vague J. La diffkrenciation sexuelle, facteur dkterminant des formes de I'obCsit.6. Presse Medicale. 1947;30:339-340.
- Desprks J-P. Dyslipidemia and obesity. Ballitre's Clin En- docrinol Metab. 1994;8:629-660.
- Kissebah AH, Evans DJ, Peiris A, Wilson CR. Endocrine characteristics in regional obesities: Role of sex steroids. In: Vague J, Bjorntorp B, Guy-Grand B, et al., eds. Metabolic Complications of Human Obesities. Amsterdam: Elsevier Sci- ence Publishers; 1985;115-130.
- Kissebah AH, Krakower GR. Regional adiposity and mor- bidity. Physiol Rev. 1994;74:761-811.
- 17B-22B. 16s OBESITY RESEARCH Vol. 6 Suppl. 1 April 1998 15508528, 1998, S1, Insulin Resistance-Dyslipidernic Syndrome, Despres 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. · DOI
- O'Brien T, Nguyen TT, Hallaway BJ, et al. The role of lipoprotein A-I and lipoprotein A-VA-I1 in predicting coro- nary heart disease. Arterioscler Thromb Vasc Biol. 1995;15: 228-23
- Lamarche B, Tchernof A, Moorjani S, et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Circulation. 1997;95:69-75.
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Increased visceral fat and decreased energy expenditure during the menopausal transition
Lovejoy, J. C., Champagne, C. M., de Jonge, L., Xie, H., & Smith, S. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.25 · Cited by 1,020 · see citing works
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972 · see citing works
Exercise for type 2 diabetes mellitus
Thomas, D., Elliott, E. J., & Naughton, G. A. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002968.pub2 · Cited by 728 · see citing works
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C. (2003) · Diabetes · doi:10.2337/diabetes.52.3.682 · Cited by 332 · see citing works
Sexual differences in the control of energy homeostasis
Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242 · see citing works
“Thus, men have greater risk to develop the metabolic syndrome as adiposity increases than premenopausal obese women do [36], [52] and [87].”
BackgroundSugars, hypertriglyceridemia, and cardiovascular disease
Fried, S. K., & Rao, S. P. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.873s · Cited by 232 · see citing works
A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice
Grove, K. L., Fried, S. K., Greenberg, A. S., Xiao, X. Q., & Clegg, D. J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.12 · Cited by 208 · see citing works
Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine
Unger, R. H. (2005) · Biochimie · doi:10.1016/j.biochi.2004.11.014 · Cited by 184 · see citing works
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Rohrich, R. J. (2001) · Plastic and Reconstructive Surgery · doi:10.1097/00006534-200108000-00035 · Cited by 130 · see citing works
Cardiovascular Risk Factors After Adolescent Bariatric Surgery
Michalsky, M. P., Inge, T. H., Jenkins, T. M., Xie, C., Courcoulas, A., Helmrath, M., Brandt, M. L., Harmon, C. M., Chen, M., Dixon, J. B., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-2485 · Cited by 124 · see citing works
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
Shi, H., Strader, A. D., Sorrell, J. E., Chambers, J. B., Woods, S. C., & Seeley, R. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00704.2007 · Cited by 85 · see citing works
Reinecke, H., Bogdanski, J., Woltering, A., Breithardt, G. Ü., Assmann, G., Kerber, S., & von Eckardstein, A. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02490-6 · Cited by 78 · see citing works
How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?
Pi-Sunyer, F. X. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00287.x · Cited by 40 · see citing works
Sofra, X., & Badami, S. (2020) · Health · doi:10.4236/health.2020.128076 · Cited by 17 · see citing works
- Authors
- Després, J.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Després, Jean‐Pierre
- ORCID
- Després, Jean‐Pierre
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 1998-04
- Volume
- 6
- Issue
- S1
- Pages
- 8S-17S
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2067880100
- Cited by
- 261
- References
- 55
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 12 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 16
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Canadian Diabetes Association
- Medical Research Council Canada
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin resistance, visceral obesity, dyslipidemia, coronary artery disease, type 2 diabetes, hypertriglyceridemia, low HDL cholesterol, visceral adipose tissue, atherogenic dyslipidemia, cardiovascular risk, apolipoprotein B, small dense LDL, hyperinsulinemia, impaired glucose tolerance
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Humans, Hyperlipidemias, Insulin Resistance, Obesity, Risk Factors, Syndrome
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