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Association Between Adiponectin and Mediators of Inflammation in Obese Women
Open accessAbstract
Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05). Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = −0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.
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“Increased inflammatory cytokines and decreased total and HMW adiponectin concentrations have been associated with obesity (45,46), intra-abdominal fat accumulation (47), insulin resistance (48), the metabolic syndrome (49), and cardiovascular disease (50).”
From Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function (2010) · cites this paper as [45]
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Metadata
- Authors
- Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M.
- Affiliations
- Max Delbrück Center (DE)
- HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, and Max Delbrück Center for Molecular Medicine, Berlin, Germany
- German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
- German Institute of Human Nutrition (DE)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-04-01
- Volume
- 52
- Issue
- 4
- Pages
- 942-947
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120192015
- Cited by
- 422
- References
- 51
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 2 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 19 · 2013: 27 · 2012: 21
- FWCI
- 25.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01KW0011)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, obesity, postmenopausal women, inflammation, C-reactive protein, interleukin-6, adipose tissue gene expression, insulin resistance, cardiovascular risk
- MeSH terms
- Adipose Tissue, Blood Pressure, Body Composition, Body Constitution, C-Reactive Protein, Female, Humans, Lipids, Middle Aged, Obesity, Proteins, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Body Mass Index, Postmenopause, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Adiponectin
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