Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys
Abstract
Adiponectin is an adipose-specific plasma protein whose plasma concentrations are decreased in obese subjects and type 2 diabetic patients. This protein possesses putative antiatherogenic and anti-inflammatory properties. In the current study, we have analyzed the relationship between adiponectin and insulin resistance in rhesus monkeys (Macaca mulatta), which spontaneously develop obesity and which subsequently frequently progress to overt type 2 diabetes. The plasma levels of adiponectin were decreased in obese and diabetic monkeys as in humans. Prospective longitudinal studies revealed that the plasma levels of adiponectin declined at an early phase of obesity and remained decreased after the development of type 2 diabetes. Hyperinsulinemic-euglycemic clamp studies revealed that the obese monkeys with lower plasma adiponectin showed significantly lower insulin-stimulated peripheral glucose uptake (M rate). The plasma levels of adiponectin were significantly correlated to M rate (r = 0.66, P < 0.001). Longitudinally, the plasma adiponectin decreased in parallel to the progression of insulin resistance. No clear association was found between the plasma levels of adiponectin and its mRNA levels in adipose tissue. These results suggest that reduction in circulating adiponectin may be related to the development of insulin resistance.
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It is thought that adiponectin can decrease the insulin resistance of obesity.
“It is thought that adiponectin can decrease the insulin resistance of obesity (28–30).”
From Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults (2004) · cites this paper as [28]
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- Authors
- Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y.
- Affiliations
- The University of Osaka (JP)
- University of Maryland, Baltimore (US)
- Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2001-05-01
- Volume
- 50
- Issue
- 5
- Pages
- 1126-1133
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120688902
- Cited by
- 1,072
- References
- 45
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 10 · 2021: 22 · 2020: 21 · 2019: 27 · 2018: 24 · 2017: 31 · 2016: 32 · 2015: 40 · 2014: 57 · 2013: 49 · 2012: 65
- FWCI
- 50.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ag002100-001)
- National Institute on Aging (AG02100)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adiponectin, insulin resistance, type 2 diabetes, rhesus monkeys, obesity, plasma adiponectin levels, glucose uptake, adipose tissue, anti-inflammatory adipokines
- MeSH terms
- Adipose Tissue, Amino Acid Sequence, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Diabetes Mellitus, Type 2, Humans, Hyperinsulinism, Insulin, Macaca mulatta, Male, Molecular Sequence Data, Obesity, Organ Size, Proteins, Glucose Clamp Technique, Sequence Alignment, Sequence Homology, Amino Acid, Primate Diseases, Disease Progression, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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