Cited by 227Retinal Diseases and TreatmentsBiochemical Acid Research StudiesAldose Reductase and Taurine

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Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats

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Kowluru, Renu A., Odenbach, Sarah·2004·Diabetes

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Abstract

Oxidative stress is increased in the retina in diabetes, and it is considered to play an important role in the development of retinopathy. α-Lipoic acid, a thiol antioxidant, has been shown to have beneficial effects on polyneuropathy and on the parameters of oxidative stress in various tissues, including nerve, kidney, and retina. The purpose of this study was to examine the effect of α-lipoic acid on retinal capillary cell apoptosis and the development of pathology in diabetes. Retina was used from streptozotocin-induced diabetic rats receiving diets supplemented with or without α-lipoic acid (400 mg/kg) for 11 months of diabetes. Capillary cell apoptosis (by terminal transferase-mediated dUTP nick-end labeling) and formation of acellular capillaries were investigated in the trypsin-digested retinal microvessels. The effect of α-lipoic acid administration on retinal 8-hydroxy-2′deoxyguanosine (8-OHdG) and nitrotyrosine levels was determined by enzyme-linked immunosorbent assay. α-Lipoic acid administration for the entire duration of diabetes inhibited capillary cell apoptosis and the number of acellular capillaries in the retina, despite similar severity of hyperglycemia in the two diabetic groups (with and without α-lipoic acid). Retinal 8-OHdG and nitrotyrosine levels were increased by over twofold and 70%, respectively, in diabetes, and α-lipoic acid administration inhibited these increases. Our results demonstrate that the long-term administration of α-lipoic acid has beneficial effects on the development of diabetic retinopathy via inhibition of accumulation of oxidatively modified DNA and nitrotyrosine in the retina. α-Lipoic acid supplementation represents an achievable adjunct therapy to help prevent vision loss in diabetic patients.

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Authors: Kowluru, R. A., & Odenbach, S.
Affiliations: Wayne State University (US)
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2004-12-01
Volume: 53
Issue: 12
Pages: 3233-3238
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.53.12.3233
OpenAlex: W2095953797
Cited by: 227
References: 73
Citations by year: 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 16 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 13 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 15 · 2012: 15
FWCI: 11.82
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords: alpha-lipoic acid, diabetic retinopathy, apoptosis, oxidative stress, 8-hydroxy-2'-deoxyguanosine, nitrotyrosine, streptozotocin-induced diabetes, thiol antioxidants, acellular capillaries, hyperglycemia, blindness prevention
MeSH terms: Animals, Diabetes Mellitus, Experimental, Diabetic Retinopathy, Thioctic Acid, Male, Retina, Retinal Vessels, Cell Death, Rats, Wistar, Oxidative Stress, Rats

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Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats

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