The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Biology of Peroxisome Proliferator-Activated Receptors
Open accessAbstract
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They act on DNA response elements as heterodimers with the nuclear retinoic acid receptor. Their natural activating ligands are fatty acids and lipid-derived substrates. PPAR-α is present in liver, heart, and, to a lesser extent, skeletal muscle. When activated, it promotes fatty acid oxidation, ketone body synthesis, and glucose sparing. Fibrates, which are used as hypolipidemic drugs, are ligands of PPAR-α. PPAR-δ is ubiquitous and could also favor fatty acid oxidation in tissues in which PPAR-α is absent or less expressed. PPAR-γ is expressed in adipose tissue, lower intestine, and cells involved in immunity. Activation of PPAR-γ induces the differentiation of preadipocytes into adipocytes and stimulates triglyceride storage. Thiazolidinediones are compounds used as hypoglycemic, muscle insulin-sensitizing agents in type 2 diabetes. Unexpectedly, they are activators of PPAR-γ. Their action on muscle insulin sensitivity may be secondary to the lowering of circulating lipids on PPAR-γ activation and to the secretion by adipocytes of insulin-sensitizing hormones such as adiponectin, all promoting glucose utilization. The PPARs are thus major regulators of lipid and glucose metabolism, allowing adaptation to the prevailing nutritional environment.
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Cites
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BackgroundGuerre-Millo, M., Gervois, P., Raspé, E., Madsen, L., Poulain, P., Derudas, B., Herbert, J.-M., Winegar, D. A., Willson, T. M., Fruchart, J.-C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16638 · Cited by 605
PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance
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Adiponectin regulation and function
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Metadata
- Authors
- Ferré, P.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-02-01
- Volume
- 53
- Issue
- suppl_1
- Pages
- S43-S50
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1968375269
- Cited by
- 776
- References
- 9
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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