Cited by 676Gut microbiota and healthGastrointestinal motility and disordersAnimal Nutrition and Physiology

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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Martinez-Guryn, Kristina, Hubert, Nathaniel, Frazier, Katya, Urlass, Saskia, Musch, Mark W., Ojeda, Patricia, Pierre, Joseph F., Miyoshi, Jun +5 more·2018·Cell Host & Microbe

Abstract

The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these diet-microbe interactions remains unclear. We determine that germ-free (GF) mice are resistant to diet-induced obesity and malabsorb fat with specifically impaired lipid digestion and absorption within the small intestine. Small bowel microbes are essential for host adaptation to dietary lipid changes by regulating gut epithelial processes involved in their digestion and absorption. In addition, GF mice conventionalized with high-fat diet-induced jejunal microbiota exhibit increased lipid absorption even when fed a low-fat diet. Conditioned media from specific bacterial strains directly upregulate lipid absorption genes in murine proximal small intestinal epithelial organoids. These findings indicate that proximal gut microbiota play key roles in host adaptability to dietary lipid variations through mechanisms involving both the digestive and absorptive phases and that these functions may contribute to conditions of over- and undernutrition.

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Authors
Martinez-Guryn, K., Hubert, N., Frazier, K., Urlass, S., Musch, M. W., Ojeda, P., Pierre, J. F., Miyoshi, J., Sontag, T. J., Cham, C. M., Reardon, C. A., Leone, V., & Chang, E. B.
Affiliations
University of Chicago (US)
Corresponding author
Chang, Eugene B.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2018-04
Volume
23
Issue
4
Pages
458-469.e5
ISSN
1931-3128 (ISSN-L)
OpenAlex
W2796527107
Cited by
663
References
53
Citations by year
2026: 54 · 2025: 85 · 2024: 101 · 2023: 98 · 2022: 88 · 2021: 93 · 2020: 82 · 2019: 43 · 2018: 18
FWCI
21.96
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK42086)
  • Digestive Diseases Research Core Center, University of Chicago (DK097268, T32DK007074)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
small intestinal microbiota, dietary fat absorption, lipid digestion, germ-free mice, diet-induced obesity, fat malabsorption, high-fat diet, jejunal microbiota, overnutrition, malnutrition
MeSH terms
Gastrointestinal Microbiome, Animals, Diet, Intestine, Small, Lipid Metabolism, Mice

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