Cited by 363Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthNitric Oxide and Endothelin Effects

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Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment

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Ceriello, Antoniom, Quagliaro, Lisa, Piconi, Ludovica, Assaloni, Roberta, Da Ros, Roberto, Maier, Amabile, Esposito, Katherine, Giugliano, Dario·2004·Diabetes

DOI 10.2337/diabetes.53.3.701

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Abstract

Adhesion molecules, particularly intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and E-selectin, have been associated with cardiovascular disease. Elevated levels of these molecules have been reported in diabetic patients. Postprandial hypertriglyceridemia and hyperglycemia are considered risk factors for cardiovascular disease, and evidence suggests that postprandial hypertriglyceridemia and hyperglycemia may induce an increase in circulating adhesion molecules. However, the distinct role of these two factors is a matter of debate. Thirty type 2 diabetic patients and 20 normal subjects ate three different meals: a high-fat meal, 75 g of glucose alone, and a high-fat meal plus glucose. Glycemia, triglyceridemia, plasma nitrotyrosine, ICAM-1, VCAM-1, and E-selectin were assayed during the tests. Subsequently, diabetic subjects took simvastatin 40 mg/day or placebo for 12 weeks. The three tests were performed again at baseline, between 3 and 6 days after starting the study, and at the end of each study. High-fat load and glucose alone produced an increase of nitrotyrosine, ICAM-1, VCAM-1, and E-selectin plasma levels in normal and diabetic subjects. These effects were more pronounced when high fat and glucose were combined. Short-term simvastatin treatment had no effect on lipid parameters, but reduced the effect on adhesion molecules and nitrotyrosine, which was observed during every different test. Long-term simvastatin treatment was accompanied by a lower increase in postprandial triglycerides, which was followed by smaller variations in ICAM-1, VCAM-1, E-selectin, and nitrotyrosine during the tests. This study shows an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on ICAM-1, VCAM-1, and E-selectin plasma levels, suggesting oxidative stress as a common mediator of such effects. Simvastatin shows a beneficial effect on oxidative stress and the plasma levels of adhesion molecules, which may be ascribed to a direct effect in addition to the lipid-lowering action of the drug.

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Authors: Ceriello, A., Quagliaro, L., Piconi, L., Assaloni, R., Da Ros, R., Maier, A., Esposito, K., & Giugliano, D.
Affiliations: Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
University of Udine (IT)
University of Campania "Luigi Vanvitelli" (IT)
ORCID: Esposito, Katherine
Giugliano, Dario
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2004-03-01
Volume: 53
Issue: 3
Pages: 701-710
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.53.3.701
OpenAlex: W2138415287
Cited by: 362
References: 43
Citations by year: 2026: 3 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 13 · 2019: 12 · 2018: 8 · 2017: 18 · 2016: 15 · 2015: 17 · 2014: 16 · 2013: 20 · 2012: 23
FWCI: 17.57
Type: journal article
Language: en
Open access: green
www.openaccessrepository.it
Licence: other-oa
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: postprandial hypertriglyceridemia, hyperglycemia, adhesion molecules, ICAM-1, VCAM-1, E-selectin, oxidative stress, nitrotyrosine, simvastatin, type 2 diabetes, cardiovascular risk, high-fat meal, glucose tolerance
MeSH terms: Hypolipidemic Agents, Diabetes Mellitus, Double-Blind Method, Electrocardiography, Female, Humans, Hyperglycemia, Male, Middle Aged, Triglycerides, Tyrosine, Hypertriglyceridemia, Body Mass Index, Oxidative Stress, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, E-Selectin, Postprandial Period, Simvastatin, Diabetes Complications

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Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment

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