Cited by 312Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

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Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome.

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Cheal, Karen L., Abbasi, Fahim, Lamendola, Cindy, McLaughlin, Tracey, Reaven, Gerald M., Ford, Earl S.·2004·Diabetes

DOI 10.2337/diabetes.53.5.1195

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Abstract

The Adult Treatment Panel III (ATP III) has published criteria for diagnosing the metabolic syndrome, a cluster of closely related abnormalities related to insulin resistance that increase cardiovascular disease risk. The present analysis was performed to evaluate the ability of these criteria to identify insulin-resistant individuals. The population consisted of 443 healthy volunteers, with measurements of BMI, blood pressure, fasting plasma glucose, triglycerides, HDL cholesterol concentrations, and steady-state plasma glucose (SSPG) concentration. Insulin resistance was defined as being in the top tertile of SSPG concentrations. Of the population, 20% satisfied ATP III criteria for the metabolic syndrome. Although insulin resistance and the presence of the metabolic syndrome were significantly associated (P < 0.001), the sensitivity and positive predictive value equaled 46% (69 of 149) and 76% (69 of 91), respectively. Being overweight, with high triglycerides, low HDL cholesterol, or elevated blood pressure, most often resulted in a diagnosis of the metabolic syndrome. Thus, the ATP III criteria do not provide a sensitive approach to identifying insulin-resistant individuals. The individual components vary both in terms of their utility in making a diagnosis of the metabolic syndrome and their relationship to insulin resistance, with the obesity and lipid criteria being most useful.

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Self-citation
Comparison of the 1997 and 2003 American Diabetes Association Classification of Impaired Fasting Glucose
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Self-citation
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Authors: Cheal, K. L., Abbasi, F., Lamendola, C., McLaughlin, T., Reaven, G. M., & Ford, E. S.
Affiliations: Brigham and Women's Hospital (US)
Stanford Medicine (US)
Centers for Disease Control and Prevention (US)
ORCID: Abbasi, Fahim
Lamendola, Cindy
McLaughlin, Tracey
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2004-05-01
Volume: 53
Issue: 5
Pages: 1195-1200
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.53.5.1195
OpenAlex: W2018346950
Cited by: 312
References: 41
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 19 · 2013: 15 · 2012: 15
FWCI: 23.56
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: metabolic syndrome, insulin resistance, Adult Treatment Panel III criteria, diagnostic sensitivity, positive predictive value, steady-state plasma glucose, triglycerides, HDL cholesterol, blood pressure, obesity, cardiovascular risk
MeSH terms: Adult, Aged, Blood Glucose, Blood Pressure, Body Weight, Diagnostic Tests, Routine, Female, Homeostasis, Humans, Insulin Resistance, Cholesterol, HDL, Male, Middle Aged, Osmolar Concentration, Predictive Value of Tests, Sensitivity and Specificity, Triglycerides, Metabolic Syndrome

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Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome.

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