Comparing Digital Therapeutic Intervention with an Intensive Obesity Management Program: Randomized Controlled Trial
Open accessAbstract
In this study, we evaluated whether the digital program Vitadio achieves comparable results to those of an intensive in-person lifestyle intervention in obesity management. This is a 12-month prospective, randomized controlled trial. Obese patients with insulin resistance, prediabetes or type 2 diabetes were included. The intervention group (IG) used Vitadio. The control group (CG) received a series of in-person consultations. Body weight and various metabolic parameters were observed and analyzed with ANOVA. The trial is ongoing and the presented findings are preliminary. Among 100 participants (29% men; mean age, 43 years; mean BMI, 40.1 kg/m2), 78 completed 3-month follow-up, and 51 have completed the 6-month follow-up so far. Participants significantly (p < 0.01) reduced body weight at 3 months (IG: −5.9 ± 5.0%; CG: −4.2 ± 5.0%) and 6 months (IG: −6.6±6.1%; CG: −7.1 ± 7.1%), and the difference between groups was not significant. The IG achieved favorable change in body composition; significant improvement in TAG (−0.6 ± 0.9 mmol/l, p < 0.01), HDL (0.1 ± 0.1%, p < 0.05), HbA1c (−0.2 ± 0.5%, p < 0.05) and FG (−0.5 ± 1.5 mmol/l, p < 0.05); and a superior (p = 0.02) HOMA-IR reduction (−2.5 ± 5.2, p < 0.01). The digital intervention achieved comparable results to those of the intensive obesity management program. The results suggest that Vitadio is an effective tool for supporting patients in obesity management and diabetes prevention.
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Vitadio complements physician-directed therapy and helps patients achieve their treatment goals.
“Built on a multimodal therapeutic approach, Vitadio complements physician-directed therapy and helps patients in achieving their treatment goals [24,25].”
From Evaluation of the Impact of Mobile Health App Vitadio in Patients With Type 2 Diabetes: Randomized Controlled Trial (2025) · cites this paper as [24]
The Introduction describes Vitadio as a multimodal program that supports self-management and personalized goal setting, and the Conclusions report improvements in weight and metabolic measures. But Materials and Methods §2.4 says the Vitadio group received the app without in-person lifestyle consultation; the study compared it with clinician-provided consultations rather than showing that it complements physician-directed therapy. Page numbers are not available in our copy. (LLM, conf=0.83)
Experimental — accuracy not yet measuredIn a study of digital intervention in patients with obesity, the intervention group exhibited significant improvements in HbA1c, fasting blood glucose, and HOMA-IR levels while retaining muscle mass and reducing body fat and obtained equivalent outcomes to an intensive obesity management program.
“In a study of digital intervention in patients with obesity, the intervention group exhibited significant improvements in HbA1c, fasting blood glucose, and HOMA-IR levels while retaining muscle mass and reducing body fat and obtained equivalent outcomes to an intensive obesity management program [37].”
From Efficacy of WeChat-Based Digital Intervention Versus Metformin in Women With Polycystic Ovary Syndrome: Randomized Controlled Trial (2024) · cites this paper as [37]
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- Authors
- Moravcová, K., Karbanová, M., Bretschneider, M. P., Sovová, M., Ožana, J., & Sovová, E.
- Affiliations
- University Hospital Olomouc (CZ)
- Charles University (CZ)
- Technische Universität Dresden (DE)
- Corresponding author
- Moravcová, Katarína
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-05-10
- Volume
- 14
- Issue
- 10
- Pages
- 2005
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9143861
- OpenAlex
- W4280607715
- Cited by
- 37
- References
- 37
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 7
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Palacký University Olomouc (IGA_LF_2020_030)
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- digital therapeutics, obesity treatment, lifestyle intervention, type 2 diabetes prevention, prediabetes, insulin resistance, weight loss, body composition, HOMA-IR, HbA1c, HDL cholesterol, triglycerides, fasting blood glucose
- MeSH terms
- Obesity Management, Adult, Body Weight, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Obesity, Prospective Studies
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