The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Postprandial Hyperglycemia and Diabetes Complications
Abstract
Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial “hyperglycemic spikes” may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes.
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“Postprandial hyperglycemia can impact microand macro-vascular complications of diabetes more than elevated fasting glucose levels, making adequate glucose control after meals beneficial.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [91]
Citations
Cites
Biochemistry and molecular cell biology of diabetic complications
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Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
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Diabetes and Cardiovascular Disease: The Framingham Study
Kannel, W. B. (1979) · JAMA · doi:10.1001/jama.1979.03290450033020 · Cited by 2,936
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
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“As far as infarction is concerned, it has been recently demonstrated by a metaanalysis that there is a continuous correlation between glucose serum levels and the seriousness of the prognosis even in nondiabetic subjects (22), while intensive insulin treatment during acute myocardial infarction reduces long-term morta…”
BackgroundEsposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961 · cited 1×
“Studies support the evidence that an acute hyperglycemia during a hyperglycemic clamp (56) or in the postprandial state (57) can increase the production of plasma interleukin-6, tumor necrosis factor- , and interleukin-18.”
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Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.-P., & Colette, C. (2006) · JAMA · doi:10.1001/jama.295.14.1681 · Cited by 2,444
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Nutritional, Dietary and Postprandial Oxidative Stress
Sies, H., Stahl, W., & Sevanian, A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.969 · Cited by 608
Impact of postprandial glycaemia on health and prevention of disease
Blaak, E. E., Antoine, J. M., Benton, D., Björck, I., Bozzetto, L., Brouns, F. J. P. H., Diamant, M., Dye, L., Hulshof, T. G., Holst, J. J., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01011.x · Cited by 513
Glycemic Variability: How Do We Measure It and Why Is It Important?
Suh, S., & Kim, J. H. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.4.273 · Cited by 439
Metadata
- Authors
- Ceriello, A.
- Affiliations
- University of Udine (IT)
- Corresponding author
- Ceriello, Antonio
- ORCID
- Ceriello, Antonio
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-01-01
- Volume
- 54
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120704605
- Cited by
- 945
- References
- 95
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 29 · 2023: 30 · 2022: 34 · 2021: 46 · 2020: 43 · 2019: 46 · 2018: 49 · 2017: 51 · 2016: 43 · 2015: 45 · 2014: 43 · 2013: 71 · 2012: 43
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- postprandial hyperglycemia, diabetes complications, cardiovascular risk, atherosclerosis, free radicals, oxidative stress, cardiovascular risk factors, diabetes management
- MeSH terms
- Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetic Angiopathies, DNA Damage, Humans, Hyperglycemia, Models, Biological, Oxidative Stress, Postprandial Period
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