The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Heritability of Insulin Secretion, Peripheral and Hepatic Insulin Action, and Intracellular Glucose Partitioning in Young and Old Danish Twins
Open accessAbstract
The etiology of type 2 diabetes is multifactorial, including genetic as well as pre- and postnatal factors that influence several different defects of glucose homeostasis, primarily in muscle, β-cells, and liver. In the present twin study, we report heritability estimates (h2) for measures of insulin secretion, insulin resistance, hepatic glucose production (HGP), and intracellular glucose partitioning using gold standard methods (euglycemic-hyperinsulinemic clamp technique, tritiated glucose infusion, indirect calorimetry, and intravenous glucose tolerance testing) among 110 younger (22–31 years of age) and 86 older (57–66 years of age) twins. To obtain a valid estimate of β-cell function, insulin secretion was adjusted for the individual degree of insulin action (disposition index). In both age-groups there was a major genetic component in the etiology of insulin secretion that was statistically significantly higher among older twins (young h2 = 0.75 [0.55–0.86] and old h2 = 0.84 [0.69–0.92], P < 0.05). The heritability estimates for peripheral insulin sensitivity (young h2 = 0.53 [0.28–0.71] and old h2 = 0.55 [0.20–0.76]) and nonoxidative glucose metabolism (young h2 = 0.50 [0.32–0.64] and old h2 = 0.48 [0.04–0.72]) were similar in younger and older twins, supporting the notion of both genetic and environmental etiological factors in the control of insulin action and nonoxidative glucose metabolism. The results suggested that HGP was predominantly controlled by nongenetic factors in both young and old twins. In conclusion, we provide further evidence for a role of genes in controlling insulin secretion, insulin action, and nonoxidative glucose metabolism. The relative contribution of genes versus environment on in vivo insulin secretion exhibited an age dependency with a slightly greater relative impact of genes among older as compared with younger twins.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, a genetic predisposition to defective insulin secretion when combined with insulin resistance can raise plasma glucose to abnormal levels.57”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Barnett, A. H., Eff, C., Leslie, R. D., & Pyke, D. A. (1981) · Diabetologia · doi:10.1007/bf00262007 · Cited by 966
Europium as a label in time-resolved immunofluorometric assays
Hemmilä, I. A., Dakubu, S., Mukkala, V.-M., Siitari, H., & Lövgren, T. N.-E. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90095-2 · Cited by 833
Kaprio, J. A., Tuomilehto, J., Koskenvuo, M., Romanov, K., Reunanen, A., Eriksson, J. G., Stengård, J., & Kesäniemi, Y. A. (1992) · Diabetologia · doi:10.1007/bf02221682 · Cited by 661
Poulsen, P., Kyvik, K. O., Vaag, A. A., & Beck‐Nielsen, H. (1999) · Diabetologia · doi:10.1007/s001250051131 · Cited by 614
Self-citationConcordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins
Newman, B. M., Selby, J. V., King, M., Slemenda, C. W., Fabsitz, R. R., & FRIEDMAN, G. D. (1987) · Diabetologia · doi:10.1007/bf00275741 · Cited by 502
Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus: a balanced overview
DeFronzo, R. A. (1992) · Diabetologia · doi:10.1007/bf00401208 · Cited by 433
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study
Perseghin, G., Ghosh, S., Gerow, K., & Shulman, G. I. (1997) · Diabetes · doi:10.2337/diab.46.6.1001 · Cited by 367
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J. P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.11.1663 · Cited by 328
Vaag, A., Henriksen, J. E., & Beck-Nielsen, H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115656 · Cited by 299 · cited 2×
“Studies in first-degree relatives have indicated a genetic origin of the defective insulin activation of muscle glycogen synthase (29).”
BackgroundSelf-citationEk, J., Andersen, G., Urhammer, S. A., Gæde, P. H., Drivsholm, T., Borch-Johnsen, K., Hansen, T., & Pedersen, O. (2001) · Diabetologia · doi:10.1007/s001250100032 · Cited by 293
Twin studies in medical research: can they tell us whether diseases are genetically determined?
Phillips, D. I. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)91086-2 · Cited by 241
Genetic versus environmental aetiology of the metabolic syndrome among male and female twins
Poulsen, P., Vaag, A. A., Kyvik, K. O., & Beck‐Nielsen, H. (2001) · Diabetologia · doi:10.1007/s001250051659 · Cited by 229
Self-citationConcordance rate for Type II diabetes mellitus in monozygotic twins: actuarial analysis
Medici, F., Hawa, M. I., Ianari, A., Pyke, D. A., & Leslie, R. D. (1999) · Diabetologia · doi:10.1007/s001250051132 · Cited by 214
Vaag, A., Henriksen, J. E., Madsbad, S., Holm, N., & Beck-Nielsen, H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117715 · Cited by 206
Self-citationHauge, M., Harvald, B., Fischer, M. B., Gotlieb-Jensen, K., Juel-Nielsen, N., Raebild, I., Shapiro, R., & Videbech, T. (1968) · Acta geneticae medicae et gemellologiae · doi:10.1017/s1120962300012749 · Cited by 189
Mednick, S. A., & Baert, A. E. (1981) · Oxford University Press eBooks · Cited by 186
The New Danish Twin Register: Establishment and Analysis of Twinning Rates
Kyvik, K. O., Green, A., & Beck‐Nielsen, H. (1995) · International Journal of Epidemiology · doi:10.1093/ije/24.3.589 · Cited by 179
Self-citationGenetic and environmental architecture of the features of the insulin-resistance syndrome.
Hong, Y., Pedersen, N. L., Brismar, K., & Fairé, U. D. (1997) · PubMed · Cited by 176
Del Prato, S., Bonadonna, R. C., Bonora, E., Gulli, G., Solini, A., Shank, M., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116226 · Cited by 170
The Clinical Implications of Impaired Glucose Tolerance
Alberti, K. G. M. M. (1996) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199611)13:11 · Cited by 148
Mayer, E. J., Newman, B. M., Austin, M. A., Zhang, D., Quesenberry, C. P., Edwards, K. L., & Selby, J. V. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008746 · Cited by 146
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study
Perseghin, G., Ghosh, S., Gerow, K., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.6.1001 · Cited by 118
Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins
Lehtovirta, M., Kaprio, J. A., Forsblom, C. M., Eriksson, J. G., Tuomilehto, J., & Groop, L. (2000) · Diabetologia · doi:10.1007/s001250050046 · Cited by 110
Abrahamsen, B., Hansen, T., Høgsberg, I. M., Fb, P., & Beck‐Nielsen, H. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.80 · Cited by 105
Self-citationNielsen, O. H., Henriksen, J. E., Holst, J. J., & Beck-Nielsen, H. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90204-8 · Cited by 100
Self-citationAge-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins
Poulsen, P., Levin, K., Beck‐Nielsen, H., & Vaag, A. A. (2002) · Diabetologia · doi:10.1007/s00125-002-0983-6 · Cited by 81
Self-citationTripathy, D., Wessman, Y., Gullström, M., Tuomi, T., & Groop, L. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1395 · Cited by 74
Does zygosity influence the metabolic profile of twins? A population based cross sectional study
Poulsen, P., Vaag, A. A., & Beck‐Nielsen, H. (1999) · BMJ · doi:10.1136/bmj.319.7203.151 · Cited by 59
Self-citationVaag, A. A., ALFORD, F. P., Henriksen, F. L., Christopher, M., & Beck‐Nielsen, H. (1995) · Diabetologia · doi:10.1007/bf00400638 · Cited by 58
Self-citationDiabetes mellitus in twins: a cooperative study in Japan
COMMITTEEONDIABETICTWINSJAPA (1988) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(88)80062-7 · Cited by 46
Neale, M. C., & Cardon, L. R. (1992) · Springer eBooks · doi:10.1007/978-94-015-8018-2_2 · Cited by 12
Vervoort, G., Goldschmidt, H. M. G., & van Doorn, L. G. (1996) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199609)13:9
Self-citation
Cited by
Sorted by citations
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
A comprehensive review on metabolic syndrome
Kaur, J. (2014) · Cardiology Research and Practice · doi:10.1155/2014/943162 · Cited by 1,889
“Similarly, a genetic predisposition to the defective insulin secretion when combined with insulin resistance can raise the plasma glucose to abnormal levels [95].”
BackgroundRetractedThe aetiology and molecular landscape of insulin resistance
James, D. E., Stöckli, J., & Birnbaum, M. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00390-6 · Cited by 736
TXNIP regulates peripheral glucose metabolism in humans
Parikh, H., Carlsson, E., Chutkow, W. A., Johansson, L. E., Storgaard, H., Poulsen, P., Saxena, R., Ladd, C., Schulze, P. C., Mazzini, M. J., et al. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040158 · Cited by 495
“The clamp protocol for studies A and C (Figure S1) involved a 2-h hyperinsulinemic euglycemic clamp preceded by a 30-min intravenous glucose tolerance test (IVGTT) to determine first-phase insulin secretion as previously described [10].”
MethodInfluentialSelf-citationRung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proença, C., Bacot, F., Balkau, B., Belisle, A., Borch-Johnsen, K., et al. (2009) · Nature Genetics · doi:10.1038/ng.443 · Cited by 479
“In vivo glucose metabolism and skeletal muscle IRS1 protein were investigated in 190 monozygotic ( n = 103, 40 pairs and 3 single twins, respectively) and same-sex dizygotic ( n = 87, 43 pairs and 1 single twin, respectively) twins aged 25–66 years without known T2”
BackgroundSelf-citation
Metadata
- Authors
- Poulsen, P., Levin, K., Petersen, I., Christensen, K., Beck-Nielsen, H., & Vaag, A.
- Affiliations
- Steno Diabetes Center, Gentofte, Denmark
- Odense University Hospital (DK)
- University of Southern Denmark (DK)
- Odense University Hospital, Odense, Denmark
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-01-01
- Volume
- 54
- Issue
- 1
- Pages
- 275-283
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2143531355
- Cited by
- 166
- References
- 35
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 5
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- heritability, insulin secretion, insulin resistance, hepatic glucose production, beta-cell function, disposition index, nonoxidative glucose metabolism, age differences, genetic versus environmental factors, twins
- MeSH terms
- Insulin Secretion, Adult, Aging, Blood Glucose, Denmark, Female, Glucose, Glycolysis, Humans, Insulin, Liver, Male, Middle Aged, Glucose Clamp Technique
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
