The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Two-Hour Seven-Sample Oral Glucose Tolerance Test and Meal Protocol
Open accessAbstract
Highly informative yet simple protocols to assess insulin secretion and action would considerably enhance the quality of epidemiological and large-scale clinical trials. In an effort to develop such protocols, a 5-h, 11-sample oral glucose tolerance test (OGTT) was performed in 100 individuals and a 7-h, 21-sample meal in another 100. Plasma glucose, insulin, and C-peptide concentrations were measured. We show that virtually the same minimal model assessment of β-cell responsivity (dynamic [Φd] and static [Φs]), insulin sensitivity (Si), and disposition index (DI) can be obtained with a reduced seven-sample 2-h protocol: Φd, reduced versus full: 871.50 vs. 873.32, r = 0.98 in OGTT and 494.88 vs. 477.99 10−9, r = 0.91 in meal; Φs: 42.36 vs. 44.35, r = 0.88 in OGTT and 35.31 vs. 35.37 10−9 min−1, r = 0.90 in meal; Si: 24.33 vs. 22.77 10−5 dl · kg−1 · min−1 per pmol/l, r = 0.89 in OGTT and 19.03 vs. 19.77 10−5 dl · kg−1 · min−1 per pmol/l, r = 0.85 in meal; and DI: 1,282.26 vs. 1,273.23, r = 0.84 in OGTT and 726.92 vs. 776.97 10−14 dl · kg−1 · min−2 per pmol/l, r = 0.84 in meal. This reduced protocol will facilitate the study of insulin secretion and action under physiological conditions in nondiabetic humans.
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“The ISI measures the overall effects of insulin to stimulate glucose disposal and inhibit glucose production.”
From The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome (2007) · cites this paper as [32]
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Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874
Self-citationBergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Self-citationKahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance
Basu, R., Breda, E., Oberg, A. L., Powell, C. C., Dalla Man, C., Basu, A., Vittone, J. L., Klee, G. G., Arora, P., Jensen, M. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1738 · Cited by 440
Self-citationKahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J. P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.11.1663 · Cited by 328
Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity
Breda, E., Cavaghan, M. K., Toffolo, G., Polonsky, K. S., & Cobelli, C. (2001) · Diabetes · doi:10.2337/diabetes.50.1.150 · Cited by 320
Self-citationThe oral glucose minimal model: Estimation of insulin sensitivity from a meal test
Della Man, C., Caumo, A., & Cobelli, C. (2002) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.995680 · Cited by 241
Self-citationDalla Man, C., Caumo, A., Basu, R., Rizza, R., Toffolo, G., & Cobelli, C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2003 · Cited by 198
Self-citationToffolo, G., Breda, E., Cavaghan, M. K., Ehrmann, D. A., Polonsky, K. S., & Cobelli, C. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e2 · Cited by 112
Self-citationSplanchnic Cortisol Production Occurs in Humans
Basu, R., Singh, R., Basu, A., Chittilapilly, E. G., Johnson, C. M., TOFFOLO, G. M., Cobelli, C., & Rizza, R. A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2051 · Cited by 111
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Muniyappa, R., Lee, S., Chen, H., & Quon, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00645.2007 · Cited by 1,643
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759
Surrogate markers of insulin resistance: A review
Singh, B. (2010) · World Journal of Diabetes · doi:10.4239/wjd.v1.i2.36 · Cited by 622
Diabetes: Models, Signals, and Control
Cobelli, C., Dalla Man, C., Sparacino, G., Magni, L., De Nicolao, G., & Kovatchev, B. P. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2036073 · Cited by 511
Self-citationIncreased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
Petersen, K. F., Dufour, S., Feng, J., Befroy, D., Dziura, J., Man, C. D., Cobelli, C., & Shulman, G. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608537103 · Cited by 403
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Metadata
- Authors
- Dalla Man, C., Campioni, M., Polonsky, K. S., Basu, R., Rizza, R. A., Toffolo, G., & Cobelli, C.
- Affiliations
- Department of Information Engineering, University of Padova, Padova, Italy
- University of Padua (IT)
- Washington University in St. Louis (US)
- Mayo Clinic (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-11-01
- Volume
- 54
- Issue
- 11
- Pages
- 3265-3273
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2141363931
- Cited by
- 179
- References
- 12
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 8 · 2018: 16 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK29953-23)
- National Institute of Biomedical Imaging and Bioengineering (EB 01975, P41EB001975)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- oral glucose tolerance test, insulin secretion, insulin sensitivity, insulin sensitivity index, disposition index, minimal model analysis, C-peptide, plasma glucose
- MeSH terms
- Insulin Secretion, Adult, Aged, 80 and over, Blood Glucose, C-Peptide, Diet, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Middle Aged, Models, Biological, Time Factors, Insulin-Secreting Cells
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