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Two-Hour Seven-Sample Oral Glucose Tolerance Test and Meal Protocol
Open accessAbstract
Highly informative yet simple protocols to assess insulin secretion and action would considerably enhance the quality of epidemiological and large-scale clinical trials. In an effort to develop such protocols, a 5-h, 11-sample oral glucose tolerance test (OGTT) was performed in 100 individuals and a 7-h, 21-sample meal in another 100. Plasma glucose, insulin, and C-peptide concentrations were measured. We show that virtually the same minimal model assessment of β-cell responsivity (dynamic [Φd] and static [Φs]), insulin sensitivity (Si), and disposition index (DI) can be obtained with a reduced seven-sample 2-h protocol: Φd, reduced versus full: 871.50 vs. 873.32, r = 0.98 in OGTT and 494.88 vs. 477.99 10−9, r = 0.91 in meal; Φs: 42.36 vs. 44.35, r = 0.88 in OGTT and 35.31 vs. 35.37 10−9 min−1, r = 0.90 in meal; Si: 24.33 vs. 22.77 10−5 dl · kg−1 · min−1 per pmol/l, r = 0.89 in OGTT and 19.03 vs. 19.77 10−5 dl · kg−1 · min−1 per pmol/l, r = 0.85 in meal; and DI: 1,282.26 vs. 1,273.23, r = 0.84 in OGTT and 726.92 vs. 776.97 10−14 dl · kg−1 · min−2 per pmol/l, r = 0.84 in meal. This reduced protocol will facilitate the study of insulin secretion and action under physiological conditions in nondiabetic humans.
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“The ISI measures the overall effects of insulin to stimulate glucose disposal and inhibit glucose production.”
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Metadata
- Authors
- Dalla Man, C., Campioni, M., Polonsky, K. S., Basu, R., Rizza, R. A., Toffolo, G., & Cobelli, C.
- Affiliations
- Department of Information Engineering, University of Padova, Padova, Italy
- University of Padua (IT)
- Washington University in St. Louis (US)
- Mayo Clinic (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-11-01
- Volume
- 54
- Issue
- 11
- Pages
- 3265-3273
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2141363931
- Cited by
- 179
- References
- 12
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 8 · 2018: 16 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK29953-23)
- National Institute of Biomedical Imaging and Bioengineering (EB 01975, P41EB001975)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- oral glucose tolerance test, insulin secretion, insulin sensitivity, insulin sensitivity index, disposition index, minimal model analysis, C-peptide, plasma glucose
- MeSH terms
- Insulin Secretion, Adult, Aged, 80 and over, Blood Glucose, C-Peptide, Diet, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Middle Aged, Models, Biological, Time Factors, Insulin-Secreting Cells
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