The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis
Abstract
Hyperplasia of adipose tissue is critical for the development of obesity, but molecular mechanisms governing normal or pathological recruitment of new adipocytes remain unclear. The extracellular signal–regulated kinase (ERK) pathway plays a pivotal role in many essential cellular functions, such as proliferation and differentiation. Using ERK1−/− mice, we investigated the role of this isoform in adipose tissue development. Mice lacking ERK1 have decreased adiposity and fewer adipocytes than wild-type animals. Furthermore, ERK1−/− mice challenged with high-fat diet are resistant to obesity, are protected from insulin resistance, and have a higher postprandial metabolic rate. To get insights into cellular mechanisms implicated in reduced adiposity in ERK1−/− animals, we analyzed adipocyte differentiation in ERK1−/− cells. Compared with wild-type control cells, mouse embryo fibroblasts and cultures of adult preadipocytes isolated from ERK1−/− adult animals exhibit impaired adipogenesis. An inhibitor of the ERK pathway does not affect the residual adipogenesis of the ERK1−/− cells, suggesting that ERK2 is not implicated in adipocyte differentiation. Our results clearly link ERK1 to the regulation of adipocyte differentiation, adiposity, and high-fat diet–induced obesity. This suggests that a therapeutic approach of obesity targeting specifically the ERK1 isoform and not ERK2 would be of particular interest.
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Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., & Hedrick, M. H. (2001) · Tissue Engineering · doi:10.1089/107632701300062859 · Cited by 7,956
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
Planat-Benard, V., Silvestre, J.-S., Cousin, B., André, M., Nibbelink, M., Tamarat, R., Clergue, M., Manneville, C., Saillan-Barreau, C., Duriez, M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000114522.38265.61 · Cited by 1,382
Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
Hu, E., Kim, J. B., Sarraf, P., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5295.2100 · Cited by 1,050
Mitotic clonal expansion: A synchronous process required for adipogenesis
Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0137044100 · Cited by 808
Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790
Neurogenic differentiation of murine and human adipose-derived stromal cells
Safford, K. M., Hicok, K. C., Safford, S. D., Halvorsen, Y.-D. C., Wilkison, W. O., Gimble, J. M., & Rice, H. E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00469-2 · Cited by 758
Chondrogenic Potential of Adipose Tissue-Derived Stromal Cells in Vitro and in Vivo
Erickson, G. R., Gimble, J. M., Franklin, D. M., Rice, H. E., Awad, H., & Guilak, F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6270 · Cited by 675
Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice
Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., & Pouysségur, J. (1999) · Science · doi:10.1126/science.286.5443.1374 · Cited by 654
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Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119
Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 623
Tanti, J.-F., & Jager, J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.07.004 · Cited by 430
MAPK signalling in cellular metabolism: stress or wellness?
Gehart, H., Kumpf, S., Ittner, A., & Ricci, R. (2010) · EMBO reports · doi:10.1038/embor.2010.160 · Cited by 326
Metadata
- Authors
- Bost, F., Aouadi, M., Caron, L., Even, P., Belmonte, N., Prot, M., Dani, C., Hofman, P., Pagès, G., Pouysségur, J., Le Marchand-Brustel, Y., & Binétruy, B.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-02-01
- Volume
- 54
- Issue
- 2
- Pages
- 402-411
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2150621637
- Cited by
- 339
- References
- 33
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bost, F., Aouadi, M., Caron, L., Even, P., Belmonte, N., Prot, M., Dani, C., Hofman, P., Pagès, G., Pouysségur, J., Le Marchand-Brustel, Y., & Binétruy, B. (2005). The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis. Diabetes. https://doi.org/10.2337/diabetes.54.2.402
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