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Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM

MÅrin, Per, Andersson, Björn, Krotkiewski, Marcin, Björntorp, Per·1994·Diabetes Care

Abstract

OBJECTIVE: To determine whether muscle fiber composition and capillary density differed between diabetic and nondiabetic subjects. RESEARCH DESIGN AND METHODS: Muscle fiber composition and capillary density were determined in biopsies from women and men with non-insulindependent diabetes mellitus (NIDDM) and compared with those of control subjects matched for gender, age, obesity, and the waist-to-hip ratio, which are all factors known to influence muscle morphology. RESULTS: Patients with NIDDM, as well as control subjects with abdominal obesity and insulin resistance, showed the same abnormalities in muscle morphology, namely, a low percentage of type I fibers, elevated type II (particularly type IIB) fibers, and a low capillary density. These changes correlated closely with insulin concentrations in both diabetic and nondiabetic groups. CONCLUSIONS: Recent information suggests that insulin may regulate myosin synthesis in muscle in the direction of the changes observed. Therefore, it is possible that muscle fiber composition abnormalities in insulin-resistant conditions are secondary to hyperinsulinemia. However, the low capillary density, hypothetically, may contribute to insulin resistance.

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Crossref · 10.2337/diacare.17.5.382

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Metadata

Authors
MÅrin, P., Andersson, B., Krotkiewski, M., & Björntorp, P.
Venue
Diabetes Care
Published
1994-05-01
Volume
17
Issue
5
Pages
382-386
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
OpenAlex
W1969927905
Cited by
342
References
0
FWCI
3.90
Type
journal article
Language
en
Open access
closed

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