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Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM
Abstract
OBJECTIVE: To determine whether muscle fiber composition and capillary density differed between diabetic and nondiabetic subjects. RESEARCH DESIGN AND METHODS: Muscle fiber composition and capillary density were determined in biopsies from women and men with non-insulindependent diabetes mellitus (NIDDM) and compared with those of control subjects matched for gender, age, obesity, and the waist-to-hip ratio, which are all factors known to influence muscle morphology. RESULTS: Patients with NIDDM, as well as control subjects with abdominal obesity and insulin resistance, showed the same abnormalities in muscle morphology, namely, a low percentage of type I fibers, elevated type II (particularly type IIB) fibers, and a low capillary density. These changes correlated closely with insulin concentrations in both diabetic and nondiabetic groups. CONCLUSIONS: Recent information suggests that insulin may regulate myosin synthesis in muscle in the direction of the changes observed. Therefore, it is possible that muscle fiber composition abnormalities in insulin-resistant conditions are secondary to hyperinsulinemia. However, the low capillary density, hypothetically, may contribute to insulin resistance.
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Metadata
- Authors
- MÅrin, P., Andersson, B., Krotkiewski, M., & Björntorp, P.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1994-05-01
- Volume
- 17
- Issue
- 5
- Pages
- 382-386
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W1969927905
- Cited by
- 342
- References
- 0
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
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