Cited by 1,203Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk FactorsDiabetes Management and Research

The DOI matches its Crossref record.

Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

Kannel, W B, McGee, D L·1979·Diabetes Care

DOI 10.2337/diacare.2.2.120

Open this paper in CoChat — free account

Abstract

This report examines prospectively, in the Framingham cohort, the relation of diabetes and impaired glucose tolerance to each of the cardiovascular sequelae, taking into account age, sex, and associated cardiovascular risk factors. The incidence of cardiovascular disease, as well as the levels of cardiovascular risk factors, were found to be higher in diabetic than in nondiabetic men and women. The relative impact of diabetes on coronary heart disease, peripheral vascular disease, or stroke incidence was the same in men and women, but for cardiovascular mortality and cardiac failure the impact is greater for women. Present evidence suggests that alleviation of associated cardiovascular risk factors is the most promising course in reducing cardiovascular sequelae in diabetic patients.

Integrity signals

Registry

Crossref · 10.2337/diacare.2.2.120

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 401–500 of 999

Diabetes mellitus and arteriographically-documented coronary artery disease
Freedman, D. S., Grucho, H. W., Bamrah, V. S., Anderson, A. J., & Barboriak, J. J. (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90118-7 · Cited by 33
“INTRODUCTION Autopsy [1, 2], clinical [3, 4], and prospective epidemiologic studies [5-11] indicate that diabetes mellitus confers at least a twofold increased risk for coronary heart disease (CHD) mortality.”
BackgroundResultInfluential
Hypothyroidism and Cardiovascular Disease: A Review
Zúñiga, D., Balasubramanian, S., Mehmood, K. T., AL-Baldawi, S. A. A., & Salazar, G. Z. (2024) · Cureus · doi:10.7759/cureus.52512 · Cited by 46
Cardiovascular impairment in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM)
Vazeou, A., Papadopoulou, A., Miha, M., et al. (2007) · European Journal of Pediatrics · doi:10.1007/s00431-007-0603-z · Cited by 32
“In contrast, other studies in adults [33, 34] and in children [35] showed increased LV dimensions in patients with T1DM.”
Result
GSTM1, GSTT1, GSTP1, and GSTA1 genetic variants are not associated with coronary artery disease in Taiwan
Yeh, H.-L., Kuo, L., Sung, F.-C., Chiang, C.-W., & Yeh, C. (2013) · Gene · doi:10.1016/j.gene.2013.02.052 · Cited by 31
C-Reactive Protein and Age-Related Macular Degeneration and Cataract: The Singapore Malay Eye Study
Boey, P. Y., Tay, W. T., Lamoureux, E. L., Tai, E. S., Mitchell, P., Wang, J. J., Saw, S., & Wong, T. Y. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4063 · Cited by 32
The importance of total cardiovascular risk assessment in clinical practice
Graham, I. M. (2006) · European Journal of General Practice · doi:10.1080/13814780600976282 · Cited by 32
“The presence of this clustering of risk factors predicts both an increased likelihood of developing overt diabetes and an increased risk of vascular disease of at least twofold in men and up to fourfold in women (19).”
Background
Diabetes and Heart Disease: An Evidence-Driven Guide to Risk Factors Management in Diabetes
Lteif, A., Mather, K., & Clark, C. (2003) · Cardiology in Review · doi:10.1097/01.crd.0000086892.07437.05 · Cited by 35
Influence of risk factors on peripheral and cerebrovascular disease in men with coronary artery disease, low high-density lipoprotein cholesterol levels, and desirable low-density lipoprotein cholesterol levels
Papademetriou, V., Narayan, P., Bloomfield, H. E., Collins, D. E., & Robins, S. J. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70023-7 · Cited by 32
Neuropathic Pain, Depression, and Cardiovascular Disease: A National Multicenter Study
Cragg, J. J., Noonan, V. K., Noreau, L., Borisoff, J., & Kramer, J. K. (2015) · Neuroepidemiology · doi:10.1159/000377726 · Cited by 32
Association between Metabolic Syndrome, Smoking Status and Coronary Artery Calcification
Lee, Y.-A., Kang, S. G., Song, S.-W., Rho, J.-S., & Kim, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122430 · Cited by 32
Tissue Doppler Imaging Identifies Asymptomatic Normotensive Diabetics with Diastolic Dysfunction and Reduced Exercise Tolerance
Saraiva, R. M., Duarte, D. M., Duarte, M. P. C., et al. (2005) · Echocardiography · doi:10.1111/j.1540-8175.2005.40051.x · Cited by 31
Patients undergoing coronary artery bypass graft surgery are at high risk of impaired glucose tolerance and diabetes mellitus during the first postoperative year
Farrer, M., Fulcher, G. R., Albers, C., Neil, H. A. W., Adams, P. C., & Alberti, K. G. M. M. (1995) · Metabolism · doi:10.1016/0026-0495(95)90099-3 · Cited by 31
Cardiovascular disease and risk factors in persons with type 2 diabetes diagnosed in a large population screening: The Nord-Trondelag Diabetes Study, Norway
Claudi, T., Midthjell, K., Holmen, J., Fougner, K. J., Kruger, O., & Wiseth, R. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00759.x · Cited by 31
Dietary Fish Oil and Insulin Action in Humans
Heine, R. J. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35698.x · Cited by 29
The prediabetic problem: Development of non-insulin-dependent diabetes mellitus and related abnormalities
Haffner, S. M. (1997) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(96)00099-2 · Cited by 31
Reasons for admission of individual with diabetes to the Tripoli Medical Center in 2015
Elhadi, A., & Faiza, H. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.07.017 · Cited by 30
High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk
Kvan, E., Pettersen, K. I., Sandvik, L., & Reikvam, A. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.11.003 · Cited by 30
Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study
Burut, D. F. P., Borai, A., Livingstone, C., & Ferns, G. A. (2009) · Cell Stress and Chaperones · doi:10.1007/s12192-009-0152-7 · Cited by 30
“intolerance are both important risk factors for cardiovascular disease ( Kannel and McGee 1979; Lakka et al. 2002; Tominaga et al. 1999).”
Background
Lipid and lipoprotein profiles in Ethiopian patients with diabetes mellitus
Siraj, E. S., Seyoum, B., Saenz, C., & Abdulkadir, J. (2006) · Metabolism · doi:10.1016/j.metabol.2005.08.002 · Cited by 30
Examination of lower targets for low-density lipoprotein cholesterol and blood pressure in diabetes—the Stop Atherosclerosis in Native Diabetics Study (SANDS)
Russell, M., Fleg, J. L., Galloway, W. J., Henderson, J. A., Howard, J., Lee, E. T., Poolaw, B., Ratner, R. E., Roman, M. J., Silverman, A., et al. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.05.021 · Cited by 30
Hyperglycemia, Hyperinsulinemia, Overweight, and High Blood Pressure in Young Adults
Pozzan, R., Brandão, A. A., da Silva, S. L. D., & Brandão, A. P. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.650 · Cited by 28
Treating dyslipidaemia in non-insulin-dependent diabetes mellitus — a special reference to statins
Papadakis, J. A., Milionis, H. J., Press, M., & Mikhailidis, D. P. (2001) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00139-8 · Cited by 30
Computational detection and interpretation of heart disease based on conditional variational auto-encoder and stacked ensemble-learning framework
Abdellatif, A., Mubarak, H., Abdellatef, H., et al. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.105644 · Cited by 29
Can Genetic Pleiotropy Replicate Common Clinical Constellations of Cardiovascular Disease and Risk?
Gottesman, O., Drill, E. N., Lotay, V., Böttinger, E. P., & Peter, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046419 · Cited by 28
“Both obesity and T2D have independently and in combination, been linked with increased risk of cardiovascular disease and death [1,2,3].”
Background
Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
Zhang, D., Zhang, X., Liu, D., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0362-0 · Cited by 29
“The increased prevalence of low platelet inhibition following clopidogrel treatment and twofold to fourfold increased risk of cardiovascular disease were found in diabetes mellitus (DM) patients compared with non-DM patients [4–9].”
Background
Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study
Du, R., Zhang, R., Lu, L., Shen, Y. H., Pu, L. J., Zhu, Z. B., Zhang, Q., Hu, J., YANG, Z. K., Ding, F. H., et al. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0792-y · Cited by 28
The clinical impact of exosomes in cardiovascular disorders: From basic science to clinical application
Ghafarian, F., Pashirzad, M., Khazaei, M., Rezayi, M., Hassanian, S. M., Ferns, G. A., & Avan, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27964 · Cited by 30
“(2) Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran (3) Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK (4) Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran (5) Department o…”
Background
Diabetic dyslipidaemia
Thambiah, S. C., & Lai, L. C. (2021) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2021.e00248 · Cited by 35
“Following the Framingham Study, diabetes became an established cardiovascular disease (CVD) risk factor [2].”
MethodInfluential
Sex-specific cardiovascular morbidity and mortality in a cohort treated for hypertension
Li, C., Engström, G., Hedblad, B., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000239287.10013.e0 · Cited by 29
Expression of intercellular adhesion molecules 1 (ICAM-1) via an osmotic effect in human umbilical vein endothelial cells exposed to high glucose medium
Taki, H., Kashiwagi, A., Tanaka, Y., et al. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00151-8 · Cited by 29
Prognostic Value of Dobutamine-Atropine Stress Myocardial Perfusion Imaging in Patients With Diabetes
Schinkel, A. F. L., Elhendy, A. A., van Domburg, R. T., Bax, J. J., Vourvouri, E. C., Sozzi, F. B., Valkema, R., Roelandt, J. R. T. C., & Poldermans, D. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1637 · Cited by 29
The mechanisms of inhibitory actions of gliclazide on neutrophils–endothelial cells adhesion and surface expression of endothelial adhesion molecules mediated by a high glucose concentration
Itoh, M., Omi, H., Okouchi, M., et al. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00219-7 · Cited by 29
Hyperglycemia, assessed according to HbA1c, and future risk of venous thromboembolism: the Tromsø study
Lerstad, G., Brodin, E. E., Enga, K. F., Jorde, R., Schirmer, H., Njølstad, I., Svartberg, J. B., Brækkan, S. K., & Hansen, J. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12498 · Cited by 29
Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells
Li, H., Ge, Y., Zhang, L., et al. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.041 · Cited by 28
Is ischemia the only factor predicting cardiovascular outcomes in all diabetes mellitus patients?
Kennedy, M., Fabris, E., Suryapranata, H., & Kedhi, E. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0533-7 · Cited by 27
Mechanisms of inhibitory activity of the aldose reductase inhibitor, epalrestat, on high glucose-mediated endothelial injury
Okayama, N., Omi, H., Okouchi, M., et al. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00178-2 · Cited by 28
Appropriate Blood Pressure Control in Type II Diabetes (ABCD Trial): Implications for Complications
Schrier, R. W., & Savage, S. (1992) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70236-6 · Cited by 28
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
Malfitano, C., Barboza, C. D. A., Mostarda, C. T., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0131-x · Cited by 28
“The predisposing factors in diabetes are associated with a two – to four – fold increased risk of coronary heart disease [3].”
Background
Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys
Edwards, I. J., Wagner, J. D., Vogl-Willis, C. A., Litwak, K. N., & Cefalu, W. T. (2004) · Cardiovascular Diabetology · doi:10.1186/1475-2840-3-6 · Cited by 28
Ischemia Imaging and Plaque Imaging in Diabetes
Raggi, P., Bellasi, A., & Ratti, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2787 · Cited by 28
Diet as preventive medicine in cardiology
de Lorgeril, M., & Salen, P. (2000) · Current Opinion in Cardiology · doi:10.1097/00001573-200009000-00009 · Cited by 28
The association between glucometabolic disturbances, traditional cardiovascular risk factors and self-rated health by age and gender: A cross-sectional analysis within the Malmö Preventive Project
Leósdóttir, M., Willenheimer, R. B., Persson, M., & Nilsson, P. M. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-118 · Cited by 27
Association of Type 2 Diabetes Susceptibility Loci With One‐Year Weight Loss in the Look AHEAD Clinical Trial
Peter, I., McCaffery, J. M., Kelley-Hedgepeth, A., Hakonarson, H. H., Reís, S. E., Wagenknecht, L. E., Kopin, A. S., Huggins, G. S., & Study, F. T. G. S. O. T. L. A. (2012) · Obesity · doi:10.1038/oby.2012.11 · Cited by 27
Insulin Resistance and Atherosclerosis
Raghavan, V. A. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.014 · Cited by 27
Effects of soy isoflavone supplementation on plasma glucose, lipids, and antioxidant enzyme activities in streptozotocin-induced diabetic rats
Hsu, C.-S., Chiu, W., & Yeh, S. L. (2003) · Nutrition Research · doi:10.1016/s0271-5317(02)00386-x · Cited by 27
Diabetic microangiopathy, genetics, environment, and treatment.
Siperstein, M. D. (1988) · American Journal of Medicine · doi:10.1016/0002-9343(88)90404-4 · Cited by 28
Blood glucose and risk of coronary heart disease.
Ostrander, L. D., Lamphiear, D. E., Carman, W. J., & Williams, G. W. (1981) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.1.1.33 · Cited by 27
Impaired glucose tolerance and risk factors for atherosclerosis.
Vaccaro, O., Rivellese, A. A., Riccardi, G., Capaldo, B., Tutino, L., Annuzzi, G., & Mancini, M. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.6.592 · Cited by 27
Valor pronóstico del electrocardiograma en pacientes con diabetes tipo 2 sin enfermedad cardiovascular conocida
de Santiago, A., García‐Lledó, A., Ramos, E., et al. (2007) · Revista Española de Cardiología · doi:10.1157/13111235 · Cited by 26
Cardiovascular risk factors in developing countries: A review of clinico-epidemiological evidence
Prasad, D. S., Kabir, Z., Dash, A. K., & Das, B. (2010) · Global Heart · doi:10.1016/j.cvdpc.2010.09.001 · Cited by 26
“Diabetes or a low high-density lipoprotein (HDL) cholesterol abolish the advantage of women over men in terms of risk for CAD [59].”
Background
Lipid and non-lipid cardiovascular risk factors in postmenopausal type 2 diabetic women with and without coronary heart disease
Russo, G. T., Giandalia, A., Romeo, E. L., Marotta, M., Alibrandi, A., Francesco, C. D., Horvath, K. V., Asztalos, B. F., & Cucinotta, D. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-013-0023-z · Cited by 26
“Women generally have a *10 year-delay in the onset of cardiovascular events as compared to men; however, diabetes seems to eliminate this ‘gender-advantage’, with diabetic women showing even a higher risk for coronary heart disease (CHD) than diabetic men [1–5].”
Background
MECHANISMS IN ENDOCRINOLOGY: Cardiovascular risk in women with type 2 diabetes mellitus and prediabetes: is it indeed higher than men?
Anagnostis, P. G., Majeed, A., Johnston, D. G., & Godsland, I. F. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0401 · Cited by 26
Decreased Lipid Peroxidation Following Periodontal Therapy in Type 2 Diabetic Patients
Sonoki, K., Nakashima, S., Takata, Y., et al. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.060088 · Cited by 26
Application of two versions of the WHO/international society of hypertension absolute cardiovascular risk assessment tools in a rural Bangladeshi population
Fatema, K., Zwar, N. A., Milton, A. H., Rahman, B., & Ali, L. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008140 · Cited by 26
Determination of personalized diabetes treatment plans using a two-delay model
Kissler, S. M., Cichowitz, C., Sankaranarayanan, S., & Bortz, D. M. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.06.005 · Cited by 27
“ronic high levels of glucose in the blood, which can lead to peripheral neuropathy, cardiovascular disease, blindness, and even death (American Diabetes Association [2], Boulton [7], Kannel and Mcgee [18]). Type I diabetes is caused by autoimmune attack on the insulin-producing pancreatic β-cells. Its onset is largely…”
Background
Screening for traditional risk factors for cardiovascular disease
Glick, M. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0168 · Cited by 26
Silent coronary artery disease in patients with diabetes mellitus
Zellweger, M. J., & Pfisterer, M. E. (2001) · Swiss Medical Weekly · doi:10.4414/smw.2001.09749 · Cited by 26
“The overall prevalence of CAD among patients with diabetes is higher than in non-diabetic patients and may be as high as 55% among patients with diabetes [ 1 ].”
BackgroundResult
Metabolic risk factors for coronary heart disease: current and future prospects
Wilson, P. W. F. (1999) · Current Opinion in Cardiology · doi:10.1097/00001573-199903000-00016 · Cited by 25
Coronary heart disease risk factors in older persons
Corti, M. C., Guralnik, J. M., & Bilato, C. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03339560 · Cited by 25
Pronóstico de los pacientes diabéticos con cardiopatía isquémica
Zamora, A., & Marrugat, J. (2002) · Revista Española de Cardiología · doi:10.1016/s0300-8932(02)76694-3 · Cited by 25
Decreased ability of high density lipoproteins to transfer cholesterol esters in non‐insulin‐dependent diabetes mellitus
Ahnadi, C.-E., Masmoudi, T., Berthezène, F., & Ponsin, G. (1993) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1993.tb00791.x · Cited by 26
Comprehensive Geriatric Assessment in the Management of Older Patients With Cardiovascular Disease
Singh, M., Spertus, J. A., Gharacholou, S. M., Arora, R. C., Widmer, R. J., Kanwar, A., Sanjanwala, R., Welle, G. A., & Al-Hijji, M. A. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.09.003 · Cited by 25
Brucellosis in Dairy Cattle and Goats in Northern Ecuador
Poulsen, K. P., Hutchins, F. T., McNulty, C. M., Tremblay, M., Zabala, C., Barragán, V., Lopez, L., Trueba, G. A., & Bethel, J. W. (2014) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.13-0362 · Cited by 25
Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii–Los Angeles–Hiroshima study
Imazu, M., Sumii, K., Yamamoto, H., et al. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00016-5 · Cited by 25
“Several prospective studies [3,4,11] have reported that the relative risk of diabetes was an independent risk factor for cardiovascular mortality in both genders.”
Background
Risk of elevated resting heart rate on the development of type 2 diabetes in patients with clinically manifest vascular diseases
Bemelmans, R. H. H., Wassink, A. M. J., van der Graaf, Y., Nathoe, H. M., Vernooij, J. W. P., Spiering, W., & Visseren, F. L. J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-1017 · Cited by 25
Plasma interleukin‐6 is associated with coagulation in poorly controlled patients with Type 2 diabetes
Aso, Y., Okumura, K., Yoshida, N., Tayama, K., Kanda, T., Kobayashi, I., Takemura, Y., & Inukai, T. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01058.x · Cited by 25
Prevalence of diabetes mellitus as well as cardiac and other main comorbidities in a representative sample of the adult Greek population in comparison with the general population
Tentolouris, A., Eleftheriadou, I., Athanasakis, K., Kyriopoulos, J. E., Tsilimigras, D. I., Grigoropoulou, P., Doupis, J., & Tentolouris, N. (2018) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2018.04.008 · Cited by 26
Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic factors
Gale, C. P., Futers, T. S., & Summers, L. K. M. (2004) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2004.004 · Cited by 25
Markers of inflammation and hypercoagulability in diabetic and nondiabetic patients with lower extremity ischemia
Thor, M., Yu, A., & Swedenborg, J. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00037-3 · Cited by 25
“Since the prevalence of cardiovascular disease is increased in patients with diabetes [10,11], it is possible that”
Background
Mortality Among Type 2 Diabetic Individuals and Associated Risk Factors: The Three City Study
Sprafka, J. M., Pankow, J. S., McGovern, P. C., & French, L. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00135.x · Cited by 25
High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes
Tian, L., Long, S., Li, C., Liu, Y., Chen, Y., Zeng, Z., & Fu, M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-54 · Cited by 24
“It has been reported that adults with diabetes are at a 2- to 4-fold increased risk of CAD events relative to those without DM [1-5] and are at about 60% increased risk of early mortality [6].”
Background
Diabetic vascular disease and the potential role of macrophage glucose metabolism
Nishizawa, T., & Bornfeldt, K. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.585346 · Cited by 24
Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes
van Herpt, T. T. W., Lemmers, R. F. H., van Hoek, M., Langendonk, J. G., Erdtsieck, R. J., Bravenboer, B., Lucas, A. E. M., Mulder, M. T., Haak, H. R., Lieverse, A. G., et al. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0245-x · Cited by 25
Diabetic foot complications: a two-year review of limb amputation in a Kelantanese population.
Yusof, M. I., Sulaiman, A. R., & Muslim, D. A. J. (2007) · PubMed · Cited by 24
Prevalence of major cardiovascular risk factors among oil and gas and energy company workers.
Mannocci, A., Pignalosa, S., Saulle, R., et al. (2015) · Annali dell Istituto Superiore di Sanità · doi:10.4415/ann_15_02_13 · Cited by 24
“Some risk factors such as family history, ethnicity and age, cannot be changed, other risk factors that can be prevented, changed or treated include tobacco exposure, harmful use of alcohol, unhealthy diets and obesity, physical inactivity, stress, high blood pressure (hypertension), diabetes and dyslipidemia [5-10].”
Background
Dietary soy prevents brain Na+, K+-ATPase reduction in streptozotocin diabetic rats
Franzon, R. C., Chiarani, F., Mendes, R. H., Belló‐Klein, A., & Wyse, Â. T. D. S. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.11.010 · Cited by 24
Effect-modifications by age and sex on the risks of coronary artery disease and revascularization procedures in relation to diabetes
Chen, H.-F., & Li, C. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.05.020 · Cited by 24
“As the risks of coronary artery disease are higher in diabetic patients [3–7], the risks associated”
BackgroundResult
G Protein-Linked Cell Signaling and Cardiovascular Functions in Diabetes/Hyperglycemia
Hashim, S., Li, Y., & Anand‐Srivastava, M. B. (2006) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:44:1:051 · Cited by 24
“An increased rate of thrombosis and accelerated atherogenesis in patients with diabetes mellitus also has been reported (1,2).”
Background
Efficacy and safety of pravastatin in the treatment of patients with type I or type II diabetes mellitus and hypercholesterolemia
Raskin, P., Ganda, O. P., Schwartz, S. L., Willard, D. A., Rosenstock, J., Lodewick, P. A., Cressman, M. D., Phillipson, B., Weiner, B. H., McGovern, M. E., et al. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80182-x · Cited by 24
Senescence and Type 2 Diabetic Cardiomyopathy: How Young Can You Die of Old Age?
Henson, S. M., & Aksentijević, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716517 · Cited by 23
Streptozotocin‐ and Alloxan‐Induced Diabetes Modifies Total Plasma and Lipoprotein Lipid Concentration and Composition without Altering Cholesteryl Ester Transfer Activity
Wasan, K. M., Ng, S. P.-Y., Wong, W., & Rodrigues, B. B. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01464.x · Cited by 22
Mild hyperhomocysteinemia and the common C677T polymorphism of methylene tetrahydrofolate reductase gene are not associated with the metabolic syndrome in Type 2 diabetes
Russo, G. T., Benedetto, A. D., Alessi, E., et al. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03345540 · Cited by 23
Alteration of glucose lowering effect of glibenclamide on single and multiple treatments with fenofibrate in experimental rats and rabbit models
Candasamy, M., Murthy, T. E. G. K., Gubiyappa, K., et al. (2014) · Journal of Basic and Clinical Pharmacy · doi:10.4103/0976-0105.139728 · Cited by 23
Predicting the Risk of Cardiovascular Comorbidities in Adult Cancer Survivors
Tashakkor, A. Y., Moghaddamjou, A., Chen, L. Y. C., & Cheung, W. Y. (2013) · Current Oncology · doi:10.3747/co.20.1470 · Cited by 23
“1 Sex Men 382 (42) 436 (31) 11,682 (49) Women 379 (58) 654 (69) 12,655 (51) Ethnicity White 492 (85) 787 (89) 11,707 (75) Black 137 (9) 158 (7) 4,958 (12) Hispanic 111 (7) 120 (4) 6,693 (13) Education Less than high school 206 (24) 271 (22) 6,410 (20) High school 167 (28) 232 (29) 4,681 (26) More than high school 259…”
Nutritional status, genetic susceptibility, and insulin resistance—important precedents to atherosclerosis
McGillicuddy, F. C., & Roche, H. M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100785 · Cited by 23
“Indeed, certain chronic inflammatory conditions also predispose to the development of CAD including insulin resistance (IR) [18], type 2 diabetes mellitus [19] and arthritis [20].”
Background
Structure based virtual screening of MDPI database: Discovery of structurally diverse and novel DPP-IV inhibitors
Tanwar, O., Tanwar, L., Shaquiquzzaman, M., Alam, M. M., & Akhter, M. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.05.076 · Cited by 23
National Prevalence of Self-Reported Coronary Heart Disease and Chronic Stable Angina Pectoris: Factor Analysis of the Underlying Cardiometabolic Risk Factors in the SuRFNCD-2011
Abbasi, M., Neishaboury, M., Koohpayehzadeh, J., Etemad, K., Meysamie, A., Asgari, F., Noshad, S., Afarideh, M., Ghajar, A., Ganji, M., et al. (2018) · Global Heart · doi:10.1016/j.gheart.2018.01.001 · Cited by 23
“A cluster of cardiometabolic risk factors has been attributed to the development of arteriosclerosis and CHD, namely the components of central obesity, hyperglycemia, dyslipidemia, and hypertension, the combination ofwhich is characterized as metabolic syndrome [7-9].”
Background
Circulating adiponectin level is associated with major adverse cardiovascular events in type 2 diabetic patients with coronary artery disease
Hung, W., Wang, C.-P., Lu, L.-F., Yu, T., Chiu, C., Chung, F., Chen, H., Houng, J., Shin, S., & Lee, Y. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-020 · Cited by 23
Severe coronary stenosis is an important factor for induction and lengthy persistence of ventricular arrhythmias during and after hemodialysis
Kitano, Y., Kasuga, H., Watanabe, M., et al. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.04.037 · Cited by 23
A prospective population based study of gender differential in mortality from cardiovascular disease and “ causes” in asymptomatic hyperglycaemics
Janghorbani, M., Jones, R. B., Gilmour, W. H., Hedley, A. J., & Zhianpour, M. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90161-9 · Cited by 23
Apolipoprotein E polymorphism affects the response to pravastatin on plasma apolipoproteins in diabetic patients
Watanabe, J., Kobayashi, K., Umeda, F., Yamauchi, T., Mimura, K., Nakashima, N., Masakado, M., Hiramatsu, S., & Nawata, H. (1993) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(93)90018-z · Cited by 24
Hormone replacement therapy can augment vascular relaxation in post-menopausal women with type 2 diabetes
Perera, M. (2002) · Human Reproduction · doi:10.1093/humrep/17.2.497 · Cited by 22
“Hormone replacement therapy can augment vascular relaxation in post-menopausal women with type 2 diabetes”
Background
Coronary Artery Calcium Score Predicts Long-Term Cardiovascular Outcomes in Asymptomatic Patients with Type 2 Diabetes
Lei, M., Wu, Y., Chung, S., Chen, C.-C., Chen, W.-C., & Hsu, Y.-C. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.59386 · Cited by 22
CaMKII Inhibition is a Novel Therapeutic Strategy to Prevent Diabetic Cardiomyopathy
Veitch, C. R., Power, A., & Erickson, J. R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.695401 · Cited by 23
Myocardial ischemia, carotid, and peripheral arterial disease and their interrelationship in type 2 diabetes patients
Poulsen, M., Henriksen, J., Dahl, J., Johansen, A., Møller, J., Gerke, O., Vach, W., Haghfelt, T., Beck-Nielsen, H., & Høilund-Carlsen, P. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9118-5 · Cited by 25
Review: Pre-diabetes: clinical relevance and therapeutic approach
Pratley, R. E., & Matfin, G. (2007) · The British Journal of Diabetes · doi:10.1177/14746514070070030401 · Cited by 22
Nova abordagem para o tratamento da diabetes: da glicemia à doença cardiovascular
Aguíar, C., Duarte, R., & Carvalho, D. M. (2019) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2018.03.013 · Cited by 22
Host and environmental interactions in diabetes mellitus
Orchard, T. J., Dorman, J. S., LaPorte, R. E., et al. (1986) · Journal of Chronic Diseases · doi:10.1016/0021-9681(86)90135-9 · Cited by 22
Age threshold for vascular prophylaxis by aspirin in patients without diabetes
Bulugahapitiya, U., Siyambalapitiya, S., Sithole, J., Fernando, D., & Idris, I. (2008) · Heart · doi:10.1136/hrt.2008.150698 · Cited by 21
Which diabetic patients should be taking aspirin?
Yudkin, J. S. (1995) · BMJ · doi:10.1136/bmj.311.7006.641 · Cited by 22
“How can this be extrapolated to patients with diabetes? Diabetes is an independent risk factor for cardiovascular disease, increasing the risk twofold to threefold in men and postmenopausal women and around fivefold in premenopausal women.”
Background

Authors: Kannel, W. B., & McGee, D. L.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1979-03-01
Volume: 2
Issue: 2
Pages: 120-126
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.2.2.120
OpenAlex: W2059537042
Cited by: 1,203
References: 0
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 40 · 2020: 31 · 2019: 39 · 2018: 41 · 2017: 38 · 2016: 43 · 2015: 55 · 2014: 50 · 2013: 35 · 2012: 36
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: diabetes mellitus, impaired glucose tolerance, cardiovascular risk, coronary artery disease, peripheral vascular disease, stroke, cardiovascular mortality, heart failure, sex differences, cardiovascular risk factors, Framingham cohort
MeSH terms: Age Factors, Aged, Cardiovascular Diseases, Female, Glucose Tolerance Test, Humans, Male, Massachusetts, Middle Aged, Prospective Studies, Risk, Sex Factors, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks