Cited by 1,203Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk FactorsDiabetes Management and Research

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Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

Kannel, W B, McGee, D L·1979·Diabetes Care

DOI 10.2337/diacare.2.2.120

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Abstract

This report examines prospectively, in the Framingham cohort, the relation of diabetes and impaired glucose tolerance to each of the cardiovascular sequelae, taking into account age, sex, and associated cardiovascular risk factors. The incidence of cardiovascular disease, as well as the levels of cardiovascular risk factors, were found to be higher in diabetic than in nondiabetic men and women. The relative impact of diabetes on coronary heart disease, peripheral vascular disease, or stroke incidence was the same in men and women, but for cardiovascular mortality and cardiac failure the impact is greater for women. Present evidence suggests that alleviation of associated cardiovascular risk factors is the most promising course in reducing cardiovascular sequelae in diabetic patients.

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“A diagnosis of diabetes mellitus was validated when any of these criteria were met: (1) medical record review indicated a healthcare provider diagnosis of diabetes mellitus; (2) the diagnosis of diabetes mellitus was directly verified by a healthcare provider; (3) the healthcare provider referred a youth with diabetes…”
Method
Oxidative stress status in patients with diabetes mellitus: relationship to diet
Dierckx, N., Horvath, G., Gils, C. V., Vertommen, J., van de Vliet, J., Leeuw, I. D., & Manuel‐y‐Keenoy, B. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601635 · Cited by 91
“Diabetes mellitus is an important risk factor for atherosclerosis, and coronary heart disease is nowadays the most frequent cause of mortality in these patients (Kannel & McGee, 1979).”
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A brief elevation of serum amyloid A is sufficient to increase atherosclerosis
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“These inflammatory diseases are characterized by chronically and significantly elevated plasma SAA among other clinical findings, and individuals with these diseases have an increased risk of developing atherosclerosis (30, 31).”
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Hyperresistinemia Is Associated With Coexistence of Hypertension and Type 2 Diabetes
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“10,11 Kunnari et al19 found the following: (1) an association between the resistin 420C G promoter variant and diastolic BP in patients with T2DM but not in the control group; (2) The 420C G variant was associated with the presence of cerebrovascular Figure.”
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Participation of high glucose concentrations in neutrophil adhesion and surface expression of adhesion molecules on cultured human endothelial cells
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Relationship Between Coronary Microvascular Dysfunction and Cardiac Energetics Impairment in Type 1 Diabetes Mellitus
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Background

Authors: Kannel, W. B., & McGee, D. L.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1979-03-01
Volume: 2
Issue: 2
Pages: 120-126
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.2.2.120
OpenAlex: W2059537042
Cited by: 1,203
References: 0
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 40 · 2020: 31 · 2019: 39 · 2018: 41 · 2017: 38 · 2016: 43 · 2015: 55 · 2014: 50 · 2013: 35 · 2012: 36
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: diabetes mellitus, impaired glucose tolerance, cardiovascular risk, coronary artery disease, peripheral vascular disease, stroke, cardiovascular mortality, heart failure, sex differences, cardiovascular risk factors, Framingham cohort
MeSH terms: Age Factors, Aged, Cardiovascular Diseases, Female, Glucose Tolerance Test, Humans, Male, Massachusetts, Middle Aged, Prospective Studies, Risk, Sex Factors, Diabetes Complications

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Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

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