Cited by 1,203Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk FactorsDiabetes Management and Research

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Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

Kannel, W B, McGee, D L·1979·Diabetes Care

DOI 10.2337/diacare.2.2.120

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Abstract

This report examines prospectively, in the Framingham cohort, the relation of diabetes and impaired glucose tolerance to each of the cardiovascular sequelae, taking into account age, sex, and associated cardiovascular risk factors. The incidence of cardiovascular disease, as well as the levels of cardiovascular risk factors, were found to be higher in diabetic than in nondiabetic men and women. The relative impact of diabetes on coronary heart disease, peripheral vascular disease, or stroke incidence was the same in men and women, but for cardiovascular mortality and cardiac failure the impact is greater for women. Present evidence suggests that alleviation of associated cardiovascular risk factors is the most promising course in reducing cardiovascular sequelae in diabetic patients.

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“The mean values of waist circumference, BMI, triglycerides, systolic blood pressure, diastolic blood pressure, and the percentages of MS and HT were decreased in the following 4 subgroups: (1) DM and HD (n = 76); (2) subjects with DM but without HD [(non-HD DM), n=827]; (3) HD but without DM (n=415); and (4) without e…”
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“Unfortunately, poor con-trol of diabetes can lead to various vascular complications, including cardiovascular disease, stroke, impaired wound healing, blindness, and amputation (Kannel and McGee 1979; Beckman et al. 2002; Brem and Tomic-Canic 2007).”
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Trends in coronary artery disease mortality among adults with diabetes: Insights from CDC WONDER (1999–2020)
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Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data
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“The Framingham risk score (FRS), which was developed for the American population, uses age, sex, SBP, LDL-C, HDL-C, and smoking as risk factors to predict the development of CHD [5].”
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Bhutto, G. M., Lokesh, R., Shah, S. K. D., et al. (2016) · International Journal of Advances in Medicine · doi:10.18203/2349-3933.ijam20164020 · Cited by 5
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“The incidence of cardiovascular risk factors and cardiovascular diseases also are higher in diabetic patients [15].”
Hyperglycemia and Diabetes in Myocardial Infarction
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“The Framingham study has demonstrated a linear increase in coronary heart disease risk with increment of total cholesterol level from 180mg upward the normal level of serum total cholesterol in adults varies from 150250mg/dl.(14) In the present study, the prevalence of dyslipidemia was 82% in males and 80% in female d…”
Background
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Authors: Kannel, W. B., & McGee, D. L.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1979-03-01
Volume: 2
Issue: 2
Pages: 120-126
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.2.2.120
OpenAlex: W2059537042
Cited by: 1,203
References: 0
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 40 · 2020: 31 · 2019: 39 · 2018: 41 · 2017: 38 · 2016: 43 · 2015: 55 · 2014: 50 · 2013: 35 · 2012: 36
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: diabetes mellitus, impaired glucose tolerance, cardiovascular risk, coronary artery disease, peripheral vascular disease, stroke, cardiovascular mortality, heart failure, sex differences, cardiovascular risk factors, Framingham cohort
MeSH terms: Age Factors, Aged, Cardiovascular Diseases, Female, Glucose Tolerance Test, Humans, Male, Massachusetts, Middle Aged, Prospective Studies, Risk, Sex Factors, Diabetes Complications

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Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

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