Cited by 531Dementia and Cognitive Impairment ResearchDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

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Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies

Strachan, Mark W J, Deary, Ian J, Ewing, Fiona M E, Frier, Brian M·1997·Diabetes Care

DOI 10.2337/diacare.20.3.438

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Abstract

Type II (non-insulin-dependent) diabetes may be associated with impaired cognitive function. A detailed search of the literature has identified 19 controlled studies in which cognitive function in type II diabetes has been examined. The studies vary widely with respect to the nature of the diabetic populations studied and the psychological tests used. Thirteen studies demonstrated that the diabetic individuals performed more poorly in at least one aspect of cognitive function. The most commonly affected cognitive ability was verbal memory. Psychomotor ability and frontal lobe function were affected less consistently. The remaining six studies showed no differences in cognitive ability between subjects with type II diabetes and nondiabetic control subjects, but none had adequate statistical power to detect a between-group difference in cognitive ability of 0.5 of a standard deviation (a medium effect size). These findings are consistent with type II diabetes being associated with an increased risk of cognitive dysfunction. However, the widespread differences in methodology between the studies should lead to a cautious interpretation of their conclusions. The etiology of any cognitive decrement in type II diabetes is likely to result from an interaction between metabolic abnormalities intrinsic to diabetes, diabetes-specific complications, and other diabetes-related disorders.

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“Large communitybased epidemiological studies have identified type 2 diabetes as a strong independent predictor of poorer performance on learning and memory tasks (Strachan et al., 1997; Ryan and Geckle, 2000).”
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“Chronic high blood glucose levels may be a significant predictive factor for Alzheimer's disease (Strachan, Deary, Ewing, & Frier, 1997 ; Workman et al, 2000 ; Arvanitakis, Wilson, Bienias, Evans, & Bennett, 2004; Alvarenga et al, 2005 ; Lopes & Argimon, 2008 ).”
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DIMINISHED PERFORMANCE ON RESPONSE-SELECTION TASKS IN TYPE 2 DIABETES
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Authors: Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M.
Affiliations: University of Edinburgh (GB)
Edinburgh Royal Infirmary (GB)
ORCID: Strachan, Mark W J
Deary, Ian J
Frier, Brian M
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1997-03-01
Volume: 20
Issue: 3
Pages: 438-445
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.20.3.438
OpenAlex: W1967789041
Cited by: 529
References: 0
Citations by year: 2025: 6 · 2024: 7 · 2023: 7 · 2022: 20 · 2021: 7 · 2020: 12 · 2019: 14 · 2018: 19 · 2017: 19 · 2016: 21 · 2015: 15 · 2014: 25 · 2013: 17 · 2012: 24
FWCI: 7.20
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 2 diabetes, cognitive impairment, verbal memory, psychomotor performance, frontal lobe function, diabetes complications, metabolic abnormalities, effect size
MeSH terms: Cognition Disorders, Diabetes Mellitus, Type 2, Risk Factors

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Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies

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