Cited by 211Antioxidant Activity and Oxidative StressAdvanced Glycation End Products researchNitric Oxide and Endothelin Effects

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Meal-Generated Oxidative Stress in Type 2 Diabetic Patients

Ceriello, Antonio, Bortolotti, Nadia, Motz, Enrico, Crescentini, Adriana, Lizzio, Sebastiano, Russo, Assunta, Tonutti, Laura, Taboga, Claudio·1998·Diabetes Care

DOI 10.2337/diacare.21.9.1529

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Abstract

OBJECTIVE: Free radical production has been reported to be increased in diabetic patients and to be involved in the pathogenesis of diabetic complications. In this study, a standardized meal was administered to 10 type 2 diabetic patients and 10 healthy matched normal subjects to evaluate its effects on plasma oxidative stress generation. RESEARCH DESIGN AND METHODS: In diabetic patients, at baseline and after the meal, plasma malondialdehyde (MDA), vitamin C, protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual cooperation, were measured. RESULTS: After the meal, plasma MDA and vitamin C increased, while protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter decreased more significantly in the diabetic subjects than in control subjects. CONCLUSIONS: This finding shows that in the absorptive phase, free radicals are produced in diabetic patients. Since plasma glucose, but not insulin, rose significantly more in diabetic subjects than in control subjects, hyperglycemia may play an important role in the generation of postprandial oxidative stress in diabetic patients.

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Authors: Ceriello, A., Bortolotti, N., Motz, E., Crescentini, A., Lizzio, S., Russo, A., Tonutti, L., & Taboga, C.
Affiliations: University of Udine (IT)
Diabetology Unit, Udine General Hospital Udine, Italy
ORCID: Ceriello, Antonio
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1998-09-01
Volume: 21
Issue: 9
Pages: 1529-1533
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.21.9.1529
OpenAlex: W2052825417
Cited by: 211
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 14
FWCI: 3.32
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: type 2 diabetes, oxidative stress, postprandial oxidative stress, free radicals, malondialdehyde, vitamin C, vitamin E, uric acid, protein thiol groups, antioxidant capacity, hyperglycemia, plasma glucose, insulin
MeSH terms: Analysis of Variance, Antioxidants, Ascorbic Acid, Blood Glucose, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Free Radicals, Humans, Male, Malondialdehyde, Middle Aged, Uric Acid, Vitamin E, Oxidative Stress, Postprandial Period

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Meal-Generated Oxidative Stress in Type 2 Diabetic Patients

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