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Meal-Generated Oxidative Stress in Type 2 Diabetic Patients
Abstract
OBJECTIVE: Free radical production has been reported to be increased in diabetic patients and to be involved in the pathogenesis of diabetic complications. In this study, a standardized meal was administered to 10 type 2 diabetic patients and 10 healthy matched normal subjects to evaluate its effects on plasma oxidative stress generation. RESEARCH DESIGN AND METHODS: In diabetic patients, at baseline and after the meal, plasma malondialdehyde (MDA), vitamin C, protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual cooperation, were measured. RESULTS: After the meal, plasma MDA and vitamin C increased, while protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter decreased more significantly in the diabetic subjects than in control subjects. CONCLUSIONS: This finding shows that in the absorptive phase, free radicals are produced in diabetic patients. Since plasma glucose, but not insulin, rose significantly more in diabetic subjects than in control subjects, hyperglycemia may play an important role in the generation of postprandial oxidative stress in diabetic patients.
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“It seems likely that vitamin D plays a paracrine modulatory role in the immune/inflammatory system (728) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [728]
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Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., & for The STOP-NIDDM Trial Research Group (2003) · JAMA · doi:10.1001/jama.290.4.486 · Cited by 1,624
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Postprandial Hyperglycemia and Diabetes Complications
Ceriello, A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.1 · Cited by 945
“This effect can be observed even in more physiologic situations that are present during meal consumption (65).”
BackgroundSelf-citationGlycemic index: overview of implications in health and disease,,,
Jenkins, D. J., Kendall, C. W., Augustin, L. S., Franceschi, S., Hamidi, M., Marchie, A., Jenkins, A. L., & Axelsen, M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.266s · Cited by 827
Vlassara, H., Cai, W., Crandall, J., Goldberg, T., Oberstein, R., Dardaine, V., Peppa, M., & Rayfield, E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242407999 · Cited by 668
de Vegt, F., Dekker, J. M., Ruhé, H. G., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., & Heine, R. J. (1999) · Diabetologia · doi:10.1007/s001250051249 · Cited by 611
“A short-term increase in blood glucose concentrations may induce oxidative stress, which might be an important factor in the aetiology of vascular complications in diabetic subjects [32, 33 ].”
BackgroundCirculating Mononuclear Cells in the Obese Are in a Proinflammatory State
Ghanim, H., Aljada, A., Hofmeyer, D., Syed, T., Mohanty, P., & Dandona, P. (2004) · Circulation · doi:10.1161/01.cir.0000142055.53122.fa · Cited by 611
Nappo, F., Esposito, K., Cioffi, M., Giugliano, G., Molinari, A. M., Paolisso, G., Marfella, R., & Giugliano, D. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01741-2 · Cited by 555
“Our data seem to indicate that an oxidative mechanism mediates the effect of a high-fat meal on cytokine and adhesion molecule levels; this hypothesis is strengthened by the evidence that another structurally unrelated antioxidant, such as glutathione, prevents the increased plasma ICAM-1 levels seen after postprandia…”
BackgroundOxidative stress and glycemic regulation
Ceriello, A. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80082-7 · Cited by 550
Self-citationHyperglycemia and Glycation in Diabetic Complications
Nègre‐Salvayre, A., Salvayre, R., Augè, N., Pamplona, R., & Portero‐Otín, M. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2484 · Cited by 426
“An oral glucose challenge and usual meal consumption could induce a decrease in antioxidant defenses (49), but a recent review stated that some of the limitations of the work relates to acute increases in glycemia and oxidative stress, (in particular, the choice of markers and of models for oxidative stress assessment…”
Glycemic index in chronic disease: a review
Augustin, L. S. A., Franceschi, S., Jenkins, D., Kendall, C. W. C., & Vecchia, C. L. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601454 · Cited by 387
“…levels of oxidative stress than healthy populations ( Clarkson et al , 1996 ; Williams et al , 1996 ; Akkus et al , 1996 ; Santini et al , 1997 ; Ceriello et al , 1998b ) and in healthy individuals postprandial hyperglycemia appears to result in increased oxidative stress ( Koska et al , 1997 ;…”
BackgroundInfluentialGlycemic index: overview of implications in health and disease,,,
Jenkins, D. J., Kendall, C. W., Augustin, L. S., Franceschi, S., Hamidi, M., Marchie, A., Jenkins, A. L., & Axelsen, M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76/1.266s · Cited by 379
Dandona, P., Mohanty, P., Ghanim, H., Aljada, A., Browne, R. W., Hamouda, W., Prabhala, A., Afzal, A., & Garg, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7150 · Cited by 397
Alternative therapies useful in the management of diabetes: A systematic review
Tripathi, P., Awanish, P., Pandey, R. D., Rashmi, S., & Goswami, S. (2011) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.90103 · Cited by 314
Rizkalla, S., Bellisle, F., & Slama, G. (2002) · British Journal of Nutrition · doi:10.1079/bjn2002715 · Cited by 277
“1999) and the generation of oxidative stress (Ceriello et al. 1998) in NIDDM.”
BackgroundBirth weight and the Metabolic Syndrome: thrifty phenotype or thrifty genotype?
Stern, M. P., Bartley, M., Duggirala, R., & Bradshaw, B. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(200003/04)16:2 · Cited by 65
Self-citationRole of Hyperglycemia in Nitrotyrosine Postprandial Generation
Ceriello, A., Quagliaro, L., Catone, B., Pascon, R., Piazzola, M., Bais, B., Marra, G., Tonutti, L., Taboga, C., & Motz, E. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1439 · Cited by 257
“The postprandial generation of an oxidative stress, with consumption of antioxidant defenses, has been demonstrated in type 2 diabetic patients (8).”
BackgroundSelf-citationOxidative stress as a therapeutic target in diabetes: revisiting the controversy
Wiernsperger, N. F. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70072-1 · Cited by 260
“In humans, OST is also seen in postprandial periods in normal individuals but diabetic patients are unable to compensate for the increased ROS [52].”
BackgroundPiconi, L., Quagliaro, L., & Ceriello, A. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.177 · Cited by 256
Self-citationMarkolf Hanefeld, E., Chiasson, J., Koehler, C., Henkel, E., Schäper, F., & Temelkova-Kurktschiev, T. S. (2004) · Stroke · doi:10.1161/01.str.0000125864.01546.f2 · Cited by 253
Mohanty, P., Ghanim, H., Hamouda, W., Aljada, A., Garg, R., & Dandona, P. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.767 · Cited by 239
Haber, C. A., Lam, T. K. T., Yu, Z., Gupta, N., Goh, T. T., Bogdanovic, E., Giacca, A., & Fantus, I. G. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2002 · Cited by 226
“In type 2 diabetic subjects, plasma malondialdehyde and oxidized LDL were increased, whereas total plasma antioxidant capacity was decreased during postprandial hyperglycemia ( 16 mM for 2 h) after a carbohydrate meal (17, 18).”
BackgroundPatel, C., Ghanim, H., Ravishankar, S. T., Sia, C. L., Viswanathan, P., Mohanty, P., & Dandona, P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0778 · Cited by 221
Martarelli, D., Verdenelli, M. C., Scuri, S., Cocchioni, M., Silvi, S., Cecchini, C., & Pompei, P. (2011) · Current Microbiology · doi:10.1007/s00284-011-9915-3 · Cited by 209
“studies suggest that postprandial hyperglycaemia produces oxidative stress, leading to complications associated with diabetes [8–10].”
BackgroundFrancois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3244-6 · Cited by 204
Ceriello, A., Bortolotti, N., Motz, E., Pieri, C., Marra, M., Tonutti, L., Lizzio, S., Feletto, F., Catone, B., & Taboga, C. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90237-8 · Cited by 197
Self-citationThe possible role of postprandial hyperglycaemia in the pathogenesis of diabetic complications
Ceriello, A. (2003) · Diabetologia · doi:10.1007/s00125-002-0931-5 · Cited by 181
“found even in more physiologic situations, for example, while eating a meal [92].”
BackgroundSelf-citationSchiekofer, S., Andrassy, M., Chen, J., Rudofsky, G., Schneider, J. G., Wendt, T., Stefan, N., Humpert, P. M., Fritsche, A., Stümvoll, M., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.3.621 · Cited by 180
“Several studies in vitro and in vivo support the concept that short-lasting hyperglycemia leads to endothelial cell dysfunction (7–10), activation of NF- B in vascular smooth muscle cells (10), activation of coagulation (11,12), and increased generation of free radicals (13,14).”
BackgroundMarra, G., Cotroneo, P., Pitocco, D., Manto, A., Leo, M. A. S. D., Ruotolo, V., Caputo, S., Giardina, B., Ghirlanda, G., & Santini, S. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.370 · Cited by 176
“This can be explained by the fact that HbA1c is a “mean” evaluation of glycemic control and reflects, only in part, glycemic fluctuations, such as postprandial hyperglycemia or disglycemia states, which may induce a pro-oxidative status and may play a significant role in the pathogenesis of diabetic complications (10,…”
BackgroundSampson, M., Gopaul, N. K., Davies, I. R., Hughes, D. A., & CARRIER, M. J. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.537 · Cited by 170
Nontraditional Risk Factors for Cardiovascular Disease in Diabetes
Fonseca, V. A., Desouza, C. V., Asnani, S., & Jialal, I. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0034 · Cited by 169
He, K., Li, X., Chen, X., Ye, X., Huang, J., Jin, Y., Li, P., Deng, Y., Jin, Q., Shi, Q., et al. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.07.033 · Cited by 166
Memişoğulları, R., & Bakan, E. (2004) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(03)00032-1 · Cited by 161
“Patients with diabetes have increased levels of plasma lipid peroxidation products (Atalay & Laaksonen, 2002; Ceriello et al., 1998; Kedziora-Kornatowska, Luciak, Blaszczyk, & Pawlak, 1998; Memisogullari et al., 2003; Nacitarhan, Özben, & Tuncer, 1995).”
BackgroundAntidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats
Zheng, T., Shu, G., Yang, Z., Mo, S., Zhao, Y., & Mei, Z. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.12.025 · Cited by 159
Dietary hyperglycemia, glycemic index and metabolic retinal diseases
Chiu, C., & Taylor, A. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.09.001 · Cited by 166
“…and oxidative stress, studies have shown that postprandial hyperglycemia depresses serum antioxidants, including lycopene and vitamin E (Ceriello et al., 1998; Rao and Agarwal, 1999), and the higher the glycemia, the greater the postprandial depression of serum antioxidants (Ceriello et al., 1998).”
Relations of glycemic index and glycemic load with plasma oxidative stress markers
Hu, Y., Block, G., Norkus, E. P., Morrow, J. D., Dietrich, M., & Hudes, M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.70 · Cited by 154
“Direct evidence from studies in both normal subjects and those with diabetes showed that induced hyperglycemia (12) or meal intake and its attendant increase in glucose (13, 14) can induce oxidative stress and reduce antioxidant defenses, and the increase in oxidative stress was significantly greater after meals that…”
BackgroundDietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review
Roumeliotis, S., Roumeliotis, A., Dounousi, E., Eleftheriadis, T., & Liakopoulos, V. (2019) · Nutrients · doi:10.3390/nu11081911 · Cited by 149
“Therefore, dietary supplementation of Vitamin E could ameliorate meal-generated OS in these high-risk patients [68].”
BackgroundPostprandial hyperglycaemia and cardiovascular complications of diabetes: An update
Ceriello, A., Davidson, J., Hanefeld, M., Leiter, L. A., Monnier, L., Owens, D. R., Tajima, N., & Tuomilehto, J. O. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.006 · Cited by 155
Self-citationCeriello, A. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.11.020 · Cited by 124
Self-citationSerafini, M., Bugianesi, R., Salucci, M., Azzini, E., Raguzzini, A., & Maiani, G. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002722 · Cited by 124
“…previous studies showing that total antioxidant capacity of plasma is significantly lower (with regard to controls) in subjects affected by HIV infection (McLemore et al. 1998), diabetes (Ceriello et al. 1998), systemic inflammatory disorders (Tsai et al. 2000) and lung cancer (Erhola et al. 1997).”
BackgroundInteractions Between Hyperglycemia and Hypoxia
Nyengaard, J. R., Ido, Y., Kilo, C., & Williamson, J. R. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2931 · Cited by 121
Reznick, A. Z., Shehadeh, N., Shafir, Y., et al. (2006) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2006.02.004 · Cited by 118
“K (mmol/L) Range [1—24] [5—27] [12—29] Median 7 25 21”
Uddin, M. J., Kim, E. H., Hannan, M. A., & Ha, H. (2021) · Antioxidants · doi:10.3390/antiox10020258 · Cited by 112
“2 Allicin Diallyl thiosulfinate; garlic(Allium sativum L.) 5/6 nephrectomy Wistar rat CKD Fibrosis, OS Antihypertensive and antioxidant effects ↑AT1R, ↑AT2R, ↑Nrf2, ↓Keap1, ↑CAT, ↑SOD, ↓HO-1, ↑eNOS [134] 3 Antroquinonol Enone; mushroom(Antrodia camphorate) Adriamycin -injected BALB/c mice FSGS OS Decrease in kidney dy…”
BackgroundInfluentialLi, Y., Peng, G., Li, Q., Wen, S., Huang, T. H.-W., Roufogalis, B. D., & Yamahara, J. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.013 · Cited by 108
Timing of Antioxidant Vitamin Ingestion Alters Postprandial Proatherogenic Serum Markers
Carroll, M. F., & Schade, D. S. (2003) · Circulation · doi:10.1161/01.cir.0000074221.68903.77 · Cited by 105
Kanner, J., Gorelik, S., Sirota, R., & Kohen, R. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300193g · Cited by 103
Select Vitamins and Minerals in the Management of Diabetes
O’Connell, B. S. (2001) · Diabetes Spectrum · doi:10.2337/diaspect.14.3.133 · Cited by 101
Insulin: An endogenous cardioprotector
Das, U. N. (2003) · Current Opinion in Critical Care · doi:10.1097/00075198-200310000-00007 · Cited by 97
McKay, D. L., Chen, C. O., Yeum, K., Matthan, N. R., Lichtenstein, A. H., & Blumberg, J. B. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-21 · Cited by 94
“Postprandial increases in biomarkers of oxidative damage and decreased antioxidant defenses (including SH groups) have been reported in both diabetic and healthy subjects [33].”
BackgroundDeng, Y., He, K., Ye, X., Chen, X., Huang, J., Li, X., Yuan, L., Jin, Y., Jin, Q., & Li, P. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.02.023 · Cited by 89
Endothelial function in the post-prandial state
de Koning, E. J. P., & Rabelink, T. J. (2002) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(01)00008-3 · Cited by 87
Antidiabetic Properties of Germinated Brown Rice: A Systematic Review
Imam, M. U., Azmi, N. H., Bhanger, M. I., Ismail, N., & Ismail, M. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/816501 · Cited by 90
“[90] had reported that even diet could promote oxidative stress in type 2 diabetes.”
BackgroundYano, M., Hasegawa, G., Ishii, M., Yamasaki, M., Fukui, M., Nakamura, N., & Yoshikawa, T. (2004) · Redox Report · doi:10.1179/135100004225004779 · Cited by 85
Targeting postprandial hyperglycemia
Rendell, M., & Jovanovič, L. (2006) · Metabolism · doi:10.1016/j.metabol.2006.05.012 · Cited by 80
“The reduced antioxidant activity in diabetes is directly related to postprandial hyperglycemia [159-162].”
BackgroundCeriello, A., Bortolotti, N., Motz, E., Lizzio, S., Catone, B., Assaloni, R., Tonutti, L., & Taboga, C. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00818.x · Cited by 78
Self-citationImam, M. U., Musa, S. N. A., Azmi, N. H., & Ismail, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012952 · Cited by 81
“In addition to other risks that have been reported for WR [6,7], our data provides yet another reason why less consumption of WR should be encouraged especially for the rice-consuming populations that use WR as a staple food.”
BackgroundResultNakamura, T., Murase, T., Nampei, M., Morimoto, N., Ashizawa, N., Iwanaga, T., & Sakamoto, R. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.055 · Cited by 80
Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies
Gerich, J. E. (2013) · International Journal of General Medicine · doi:10.2147/ijgm.s51665 · Cited by 88
“One of the proposed mechanisms of diabetic vascular disease is the observed increase in oxidative stress that occurs following consumption of meals that produce a high level of glycemia.(14,15) This oxidative stress has been shown to induce endothelial dysfunction and increase inflammation, vasoconstriction, and carot…”
BackgroundOZDEMIR, G., Ozden, M., Kır, H. M., Kuşkay, S., Çetinalp, P., & Tarkun, İ. (2005) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/0004563053492838 · Cited by 77
Ceriello, A., Piconi, L., Quagliaro, L., Wang, Y., Schnabel, C. A., Ruggles, J. A., Gloster, M., Maggs, D. G., & Weyer, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.632 · Cited by 75
Self-citationReview Paper: Oxidative Stress Evaluation in Diabetes
Mercuri, F., Quagliaro, L., & Ceriello, A. (2000) · Diabetes Technology & Therapeutics · doi:10.1089/15209150050502014 · Cited by 71
“60 73–77 In our study, 52 NIDDM patients show decreased levels of SH and uric acid, high levels of vitamin E and unchanged values of vitamin C. 55–58 In our studies, 52,53,78 we found low levels of TRAP in NIDDM patients: these data suggest the existence of a low antioxidant defence in diabetes.”
Self-citationChiasson, J., Josse, R. G., Markolf Hanefeld, E., & Laakso, M. (2017) · Cited by 71
Postprandial oxidative stress in response to dextrose and lipid meals of differing size
Bloomer, R. J., Kabir, M. M., Marshall, K. E., Canale, R. E., & Farney, T. M. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-79 · Cited by 70
“It should be noted that besides our previous work, both MDA and H2O2 have been used by other investigators in previous studies of postprandial oxidative stress: MDA [20,33,44] and H2O2 [31,45].”
BackgroundResultNatural Alkaloids and Diabetes Mellitus: A Review
Ajebli, M., Khan, H., & Eddouks, M. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200821124817 · Cited by 74
Effect of the postprandial state on nontraditional risk factors
Lebovitz, H. E. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01833-1 · Cited by 68
Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice
Mita, T., Otsuka, A., Azuma, K., Uchida, T., Ogihara, T., Fujitani, Y., Hirose, T., Mitsumata, M., Kawamori, R., & Watada, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.118 · Cited by 67
Mazloom, Z., Hejazi, N., Dabbaghmanesh, M. H., Tabatabaei, H.-R., Ahmadi, A., & Ansar, H. (2011) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2011.900.904 · Cited by 66
Postprandial lipid oxidation and cardiovascular disease risk
Bowen, P. E., & Borthakur, G. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0089-3 · Cited by 67
“These increases were small or nonexistent in nondiabetic subjects fed normal-sized meals [42, 46 ] except for nitrotyrosine, which increased about 30% in response to a meal containing 75 g of fat or 75 g of glucose.”
BackgroundDandona, P., Aljada, A., & Bandyopadhyay, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.516 · Cited by 63
The role of hyperglycemia in the induction of oxidative stress and inflammatory process.
Vidigal, F. D. C., Cocate, P. G., Pereira, L. G., & Alfenas, R. D. C. G. (2012) · PubMed · doi:10.3305/nh.2012.27.5.5917 · Cited by 64
Delorme, S., & Chiasson, J. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.005 · Cited by 61
Diabetes mellitus: oxidative stress and wine
Caimi, G., Carollo, C., & Presti, R. L. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125002324 · Cited by 58
Saxena, R. R., Madhu, S. V., Shukla, R., Prabhu, K. M., & Gambhir, J. K. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.03.036 · Cited by 58
Assaloni, R., ROS, R. D., Quagliaro, L., Piconi, L., Maier, A., Zuodar, G., Motz, E., & Ceriello, A. (2005) · Diabetologia · doi:10.1007/s00125-005-1849-5 · Cited by 56
“However, the effect of the postprandial state, particularly postprandial hyperglycaemia, on CVD is still a matter of debate [21, 22]; studies show that postprandial hyperglycaemia is accompanied by an increase of both oxidative stress and inflammatory markers [11–15].”
BackgroundSelf-citationPodell, B. K., Ackart, D. F., Kirk, N. M., Eck, S. P., Bell, C., & Basaraba, R. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046824 · Cited by 52
Eleazu, C. O., Okafor, P. N., & Ahamefuna, I. (2010) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2010.1052.1057 · Cited by 53
Siegelaar, S. E., Barwari, T., Kulik, W., Hoekstra, J. B. L., & DeVries, J. H. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500112 · Cited by 53
Tamita, K., Katayama, M., Takagi, T., Akasaka, T., Yamamuro, A., Kaji, S., Morioka, S., & Kihara, Y. (2007) · Circulation Journal · doi:10.1253/circj.71.834 · Cited by 52
Chan, C.-W., Yu, C.-L., Lin, J., Hsieh, Y., Lin, C., Hung, C.-Y., Li, C.-H., Liao, Y., Lo, C., Huang, J., et al. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0663-6 · Cited by 52
“Postprandial hyperglycemia is associated with an increase in oxidative stress, which in turn leads to endothelial dysfunction and subsequent cardiovascular diseases including ischemic stroke [35, 36].”
BackgroundEffect of Short-Term Ketogenic Diet on Redox Status of Human Blood
Nazarewicz, R. R., Ziółkowski, W., Vaccaro, P. S., & Ghafourifar, P. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0540 · Cited by 53
“High blood glucose in diabetic patients facilitates lipid peroxidation and decreases SH content, 23 whereas KDs are carbohydrate restricted and do not increase blood glucose in healthy subjects.”
Straface, E., Rivabene, R., Masella, R., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6340 · Cited by 49
Clinical relevance of the oxidative stress concept
Haffner, S. M. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80083-9 · Cited by 48
Variations in Postprandial Blood Glucose Responses and Satiety after Intake of Three Types of Bread
Lunde, M. S. H., Hjellset, V. T., Holmboe‐Ottesen, G., & Høstmark, A. T. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/437587 · Cited by 50
“, intake of a carbohydrate meal is followed by oxidative stress that is related to the level of hyperglycemia [34], and to fluctuations in blood glucose levels [14, 16, 35].”
BackgroundLipid peroxidation and atherosclerosis in type II diabetes
Oranje, W. A., & Wolffenbuttel, B. H. R. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90050-1 · Cited by 46
Taş, S., Sarandöl, E., Ayvalık, S. Z., Serdar, Z., & Dirican, M. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.09.018 · Cited by 46
Corpeleijn, E., Saris, W. H. M., Jansen, E. H. J. M., Roekaerts, P. M. H. J., Feskens, E. J. M., & Blaak, E. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0668 · Cited by 46
“Impairments in lipid (33) and glucose (34) handling may both lead to oxidative stress.”
BackgroundEffect of Catha edulis (khat) chewing on plasma lipid peroxidation
Al-Zubairi, A. S., Al‐Habori, M., & Al-Geiry, A. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00101-6 · Cited by 45
Insulin as an anti-inflammatory and antiatherosclerotic hormone
Dandona, P., Dhindsa, S., Aljada, A., & Garg, R. (2003) · Clinical cornerstone · doi:10.1016/s1098-3597(03)90062-7 · Cited by 44
Kumar, A., Satheesh, G., Vijayakumar, G., Chandran, M., Prabhu, P. R., Simon, L., Kutty, V. R., Kartha, C. S., & Jaleel, A. (2020) · Scientific Reports · doi:10.1038/s41598-019-57257-2 · Cited by 42
Oxidative stress: The special case of diabetes
Wiernsperger, N. F. (2003) · BioFactors · doi:10.1002/biof.5520190103 · Cited by 43
Oral glucose loading attenuates endothelial function in normal individual
Watanabe, K., Oba, K., Suzuki, T., Ouchi, M., Suzuki, K., Futami‐Suda, S., Sekimizu, K.-I., Yamamoto, N., & Nakano, H. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02424.x · Cited by 42
Oxidative Stress in Diabetes Mellitus: Is There a Role for Hypoglycemic Drugs and/or Antioxidants?
Erejuwa, O. O. (2012) · InTech eBooks · doi:10.5772/32741 · Cited by 41
“Evidence implicates the role of oxidative stress in the different stages of the development of diabetes mellitus, starting from the pre-diabetes state, impaired glucose tolerance, postprandial hyperglycemia, mild diabetes and finally to overt diabetes mellitus (Ceriello et al., 1998).”
Postprandial insulin resistance as an early predictor of cardiovascular risk.
Lautt, W. W. (2007) · PubMed Central · Cited by 41
Jax, T. W., Stirban, A. O., Terjung, A., Esmaeili, H. A., Berk, A., Thiemann, S., CHILTON, R. J., von Eynatten, M., & Marx, N. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0493-3 · Cited by 38
Energetic investment associated with vitellogenesis induces an oxidative cost of reproduction
Webb, A. C., Iverson, J. B., Knapp, C., et al. (2018) · Journal of Animal Ecology · doi:10.1111/1365-2656.12936 · Cited by 39
Hasegawa, G., Yamamoto, Y., Zhi, J., Tanino, Y., Yamasaki, M., Yano, M., Nakajima, T., Fukui, M., Yoshikawa, T., & Nakamura, N. (2005) · Acta Diabetologica · doi:10.1007/s00592-005-0199-6 · Cited by 38
“Oxidative stress has also been implicated in the pathogenesis of atherosclerotic vascular disease [4] with several studies demonstrating that both acute postprandial hyperglycaemia and glucose loading induced oxidative stress in humans [5, 6].”
BackgroundThe response of γ vitamin E to varying dosages of α vitamin E plus vitamin C
Gutierrez, A., de Serna, D. G., Robinson, I., & Schade, D. S. (2009) · Metabolism · doi:10.1016/j.metabol.2008.11.003 · Cited by 37
“Hyperglycemia may increase free radical production through mechanisms of lipoprotein glycation, glucose autooxidation, and polyol pathway activation [44].”
Postprandial hyperglycemia and endothelial function in type 2 diabetes: focus on mitiglinide
Kitasato, L., Tojo, T., Hatakeyama, Y., Kameda, R., Hashikata, T., & Yamaoka‐Tojo, M. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-79 · Cited by 36
“Postprandial acceleration of oxidative stress and inflammation has been observed in patients with type 2 diabetes [49,55-58].”
BackgroundStimulation of Urinary TGF-β and Isoprostanes in Response to Hyperglycemia in Humans
McGowan, T., Dunn, S., Falkner, B. E., & Sharma, K. (2005) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00990905 · Cited by 36
“(37) that individuals with diabetes have an increased level of free radical generation after a standard meal compared with individuals without diabetes.”
BackgroundEffect of taxifolin on development of retinopathy in alloxan-induced diabetic rats
Ahiskali, I., Pinar, C. L., Kiki, M., Mammadov, R., Bilgin, A. Ö., Hacımüftüoğlu, A., Çankaya, M., Çimen, F. K., & Altuner, D. (2019) · Cutaneous and Ocular Toxicology · doi:10.1080/15569527.2019.1588289 · Cited by 35
Metadata
- Authors
- Ceriello, A., Bortolotti, N., Motz, E., Crescentini, A., Lizzio, S., Russo, A., Tonutti, L., & Taboga, C.
- Affiliations
- University of Udine (IT)
- Diabetology Unit, Udine General Hospital Udine, Italy
- ORCID
- Ceriello, Antonio
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1998-09-01
- Volume
- 21
- Issue
- 9
- Pages
- 1529-1533
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2052825417
- Cited by
- 211
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 14
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- type 2 diabetes, oxidative stress, postprandial oxidative stress, free radicals, malondialdehyde, vitamin C, vitamin E, uric acid, protein thiol groups, antioxidant capacity, hyperglycemia, plasma glucose, insulin
- MeSH terms
- Analysis of Variance, Antioxidants, Ascorbic Acid, Blood Glucose, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Free Radicals, Humans, Male, Malondialdehyde, Middle Aged, Uric Acid, Vitamin E, Oxidative Stress, Postprandial Period
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