The DOI matches its Crossref record.
Meal-Generated Oxidative Stress in Type 2 Diabetic Patients
Abstract
OBJECTIVE: Free radical production has been reported to be increased in diabetic patients and to be involved in the pathogenesis of diabetic complications. In this study, a standardized meal was administered to 10 type 2 diabetic patients and 10 healthy matched normal subjects to evaluate its effects on plasma oxidative stress generation. RESEARCH DESIGN AND METHODS: In diabetic patients, at baseline and after the meal, plasma malondialdehyde (MDA), vitamin C, protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual cooperation, were measured. RESULTS: After the meal, plasma MDA and vitamin C increased, while protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter decreased more significantly in the diabetic subjects than in control subjects. CONCLUSIONS: This finding shows that in the absorptive phase, free radicals are produced in diabetic patients. Since plasma glucose, but not insulin, rose significantly more in diabetic subjects than in control subjects, hyperglycemia may play an important role in the generation of postprandial oxidative stress in diabetic patients.
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“It seems likely that vitamin D plays a paracrine modulatory role in the immune/inflammatory system (728) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [728]
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Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., & for The STOP-NIDDM Trial Research Group (2003) · JAMA · doi:10.1001/jama.290.4.486 · Cited by 1,624
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Postprandial Hyperglycemia and Diabetes Complications
Ceriello, A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.1 · Cited by 945
“This effect can be observed even in more physiologic situations that are present during meal consumption (65).”
BackgroundSelf-citationGlycemic index: overview of implications in health and disease,,,
Jenkins, D. J., Kendall, C. W., Augustin, L. S., Franceschi, S., Hamidi, M., Marchie, A., Jenkins, A. L., & Axelsen, M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.266s · Cited by 827
Vlassara, H., Cai, W., Crandall, J., Goldberg, T., Oberstein, R., Dardaine, V., Peppa, M., & Rayfield, E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242407999 · Cited by 668
Metadata
- Authors
- Ceriello, A., Bortolotti, N., Motz, E., Crescentini, A., Lizzio, S., Russo, A., Tonutti, L., & Taboga, C.
- Affiliations
- University of Udine (IT)
- Diabetology Unit, Udine General Hospital Udine, Italy
- ORCID
- Ceriello, Antonio
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1998-09-01
- Volume
- 21
- Issue
- 9
- Pages
- 1529-1533
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2052825417
- Cited by
- 211
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 14
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- type 2 diabetes, oxidative stress, postprandial oxidative stress, free radicals, malondialdehyde, vitamin C, vitamin E, uric acid, protein thiol groups, antioxidant capacity, hyperglycemia, plasma glucose, insulin
- MeSH terms
- Analysis of Variance, Antioxidants, Ascorbic Acid, Blood Glucose, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Free Radicals, Humans, Male, Malondialdehyde, Middle Aged, Uric Acid, Vitamin E, Oxidative Stress, Postprandial Period
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