Cited by 951Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

Postprandial Hyperglycemia and Diabetes Complications

Ceriello, Antonio·2005·Diabetes

Abstract

Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial “hyperglycemic spikes” may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes.

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Registry

Crossref · 10.2337/diabetes.54.1.1

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  • Postprandial hyperglycemia can impact microvascular and macrovascular complications of diabetes more than elevated fasting glucose levels.

    “Postprandial hyperglycemia can impact microand macro-vascular complications of diabetes more than elevated fasting glucose levels, making adequate glucose control after meals beneficial.”

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Authors
Ceriello, A.
Affiliations
University of Udine (IT)
Corresponding author
Ceriello, Antonio
Venue
Diabetes
Published
2005-01-01
Volume
54
Issue
1
Pages
1-7
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2120704605
Cited by
945
References
95
Citations by year
2026: 18 · 2025: 27 · 2024: 29 · 2023: 30 · 2022: 34 · 2021: 46 · 2020: 43 · 2019: 46 · 2018: 49 · 2017: 51 · 2016: 43 · 2015: 45 · 2014: 43 · 2013: 71 · 2012: 43
FWCI
6.59
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
postprandial hyperglycemia, diabetes complications, cardiovascular risk, atherosclerosis, free radicals, oxidative stress, cardiovascular risk factors, diabetes management
MeSH terms
Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetic Angiopathies, DNA Damage, Humans, Hyperglycemia, Models, Biological, Oxidative Stress, Postprandial Period

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