Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study.
Abstract
OBJECTIVE: To identify risk factors for incident coronary heart disease (CHD). RESEARCH DESIGN AND METHODS: A total of 175 Japanese-American men without CHD were followed for up to 10 years. Baseline variables were blood pressure, weight, BMI, fat areas by computed tomography, skinfold thicknesses, abdominal circumference, plasma insulin, C-peptide, cholesterol, LDL cholesterol, HDL cholesterol, HDL2 cholesterol, and HDL3 cholesterol, triglycerides, apoproteins A1 and B, and diagnosis of diabetes and hypertension. CHD was diagnosed by electrocardiogram and clinical events. Logistic regression was used to estimate odds ratio. RESULTS: There were 50 incident cases of CHD. Using univariate logistic regression analysis, significant risk factors were intra-abdominal fat (P = 0.0090), fasting glucose (P = 0.0002), 2-h glucose (P = 0.0008), fasting HDL cholesterol (P = 0.0086), fasting HDL2 cholesterol (P = 0.030), fasting HDL3 cholesterol (P = 0.018), fasting triglycerides (P = 0.013), systolic (P = 0.0007) and diastolic blood pressure (P = 0.0002), and presence of diabetes (P = 0.0023). Multiple logistic regression models adjusted for BMI and age showed that intra-abdominal fat accounted for the effects of HDL cholesterol or triglycerides. In a multiple logistic regression model that included intra-abdominal fat, all systolic blood pressure and fasting glucose were significant. Substituting diastolic blood pressure for systolic blood pressure and 2-h glucose or diabetes status for fasting glucose produced similar results. CONCLUSIONS: Visceral adiposity, blood pressure, and plasma glucose are important independent risk factors for incident CHD in this population of diabetic and nondiabetic Japanese-American men.
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Approximately half of CAD patients had excess visceral fat accumulation.
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Self-citationKinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
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Piché, M.-E., Poirier, P., Lemieux, I., & Després, J.-P. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.06.004 · Cited by 558 · see citing works
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Self-citationDing, J., Hsu, F., Harris, T. B., Liu, Y., Kritchevsky, S. B., Szklo, M., Ouyang, P., Espeland, M. A., Lohman, K. K., Criqui, M. H., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27358 · Cited by 476 · see citing works
Canoy, D., Boekholdt, S. M., Wareham, N., Luben, R., Welch, A., Bingham, S., Buchan, I., Day, N., & Khaw, K.-T. (2007) · Circulation · doi:10.1161/circulationaha.106.673756 · Cited by 472 · see citing works
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“…significant differences exist between the expression profile of adipocyte 113Quantitative Histomorphometry of Adipose Tissue genes between tissues andwithin tissues (Brochu et al., 2001; Fujimoto et al., 1999; Kloting et al., 2010; Lau et al., 2011; Lefebvre et al., 1998; Nicklas et al., 2004).”
Ross, R., Berentzen, T. L., Bradshaw, A. J., Janssen, I., Kahn, H. S., Katzmarzyk, P. T., Kuk, J. L., Seidell, J. C., Snijder, M. B., Sørensen, T. I. A., et al. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00411.x · Cited by 353 · see citing works
Regensteiner, J. G., Golden, S., Huebschmann, A. G., Barrett-Connor, E., Chang, A. Y., Chyun, D., Fox, C. S., Kim, C., Mehta, N., Reckelhoff, J. F., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000343 · Cited by 334 · see citing works
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“The studies of Fujimoto and colleagues (13,16) in Japanese Americans over the last 10 years show that visceral adiposity is associated with and predicts the development of type 2 diabetes, coronary heart disease, and hypertension.”
BackgroundAtherogenic Dyslipidemia: Cardiovascular Risk and Dietary Intervention
Musunuru, K. (2010) · Lipids · doi:10.1007/s11745-010-3408-1 · Cited by 318 · see citing works
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Park, Y., Allison, D. B., Heymsfield, S. B., & Gallagher, D. (2001) · Obesity Research · doi:10.1038/oby.2001.49 · Cited by 304 · see citing works
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Nicklas, B. J. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh281 · Cited by 294 · see citing works
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Ryo, M., Maeda, K., Onda, T., Katashima, M., Okumiya, A., Nishida, M., Yamaguchi, T. F., Funahashi, T., Matsuzawa, Y., Nakamura, T., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.451 · Cited by 273 · see citing works
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BackgroundThe metabolic syndrome and cardiovascular disease
Bonora, E. (2006) · Annals of Medicine · doi:10.1080/07853890500401234 · Cited by 231 · see citing works
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BackgroundOptimal waist circumference cutoffs for abdominal obesity in Chinese
Bao, Y., Lu, J., Wang, C., Yang, M., Li, H., Zhang, X., Zhu, J., Lu, H., Jia, W., & Xiang, K. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.03.001 · Cited by 224 · see citing works
Hayashi, T., Boyko, E., Leonetti, D., McNeely, M., Newell-Morris, L., Kahn, S., & Fujimoto, W. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.650 · Cited by 245 · see citing works
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Lim, S. K., & Meigs, J. B. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303035 · Cited by 218 · see citing works
“In stark contrast, relatively small numbers of studies reported an independent role of VAT in cardiovascular events.(11,12) A 10-year follow-up study with Japanese Americans showed that VAT was an independent risk factor for incident coronary artery disease.”
Kadowaki, T., Sekikawa, A. M., Murata, K., Maegawa, H., Takamiya, T., Okamura, T., El‐Saed, A., Miyamatsu, N., Edmundowicz, D., Kita, Y., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803248 · Cited by 216 · see citing works
Nicklas, B., Penninx, B., Ryan, A., Berman, D., Lynch, N., & Dennis, K. E. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1413 · Cited by 206 · see citing works
Flint, A. J., Rexrode, K. M., Hu, F. B., Glynn, R. J., Caspard, H., Manson, J. E., Willett, W. C., & Rimm, E. B. (2010) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2010.01.001 · Cited by 179 · see citing works
Ectopic fat and cardiometabolic and vascular risk
Lim, S. K., & Meigs, J. B. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.077 · Cited by 174 · see citing works
Arad, Y., Newstein, D., Cadet, F., Roth, M., & Guerci, A. D. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100257 · Cited by 172 · see citing works
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Canoy, D. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328313133a · Cited by 171 · see citing works
Klopfenstein, B. J., Kim, M. S., Krisky, C. M., Szumowski, J., Rooney, W. D., & Purnell, J. Q. (2012) · British Journal of Radiology · doi:10.1259/bjr/57987644 · Cited by 159 · see citing works
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Al‐Sofiani, M. E., Ganji, S. S., & Kalyani, R. R. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.03.007 · Cited by 158 · see citing works
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Czernichow, S., Kengne, A. P., Huxley, R., Batty, G. D., de Galan, B. E., Grobbee, D. E., Pillai, A., Zoungas, S., Marre, M., Woodward, M., et al. (2010) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32833c1aa3 · Cited by 149 · see citing works
“Other studies have also shown that visceral fat is more closely related to WHR or even WC than to BMI,(37) and as a consequence may have a stronger influence on CVD risk.(20,38,39) Furthermore, relationships between BMI and CVD risk may be attributable to the relationship between BMI and diabetes.”
BackgroundLee, J., Pedley, A., Hoffmann, U., Massaro, J. M., Levy, D. A., & Long, M. T. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.02.002 · Cited by 148 · see citing works
Janiszewski, P. M., Oeffinger, K. C., Church, T. S., Dunn, A. L., Eshelman, D. A., Victor, R. G., Brooks, S., Turoff, A. J., Sinclair, E., Murray, J. C., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2178 · Cited by 144 · see citing works
Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature
Hoyos, C. M., Melehan, K. L., Liu, P. Y., Grunstein, R. R., & Phillips, C. L. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.003 · Cited by 142 · see citing works
Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?
Ross, R., & Janiszewski, P. M. (2008) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(08)71046-8 · Cited by 141 · see citing works
Physical Activity, Obesity and Cardiovascular Diseases
Lakka, T. A., & Bouchard, C. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-27661-0_4 · Cited by 140 · see citing works
High-density lipoprotein subclasses and their relationship to cardiovascular disease
Superko, H. R., PENDYALA, L. K., Williams, P. T., Momary, K. M., King, S. B., & Garrett, B. C. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.03.001 · Cited by 139 · see citing works
Gordura visceral e síndrome metabólica: mais que uma simples associação
Filho, F. F. R., Mariosa, L. S. S., Ferreira, S. R. G., & Zanella, M. T. (2006) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302006000200009 · Cited by 126 · see citing works
Cardiovascular Aspects of Sexual Medicine
Jackson, G., Montorsi, P., Adams, M. A., Anis, T. H., El‐Sakka, A. I., Miner, M. M., Vlachopoulos, C. V., & Kim, E. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01779.x · Cited by 125 · see citing works
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Hoffman, D. J., Wang, Z., Gallagher, D., & Heymsfield, S. B. (2005) · Obesity Research · doi:10.1038/oby.2005.9 · Cited by 123 · see citing works
Bouchi, R., Asakawa, M., Ohara, N., Nakano, Y., Takeuchi, T., Murakami, M., Sasahara, Y., Numasawa, M., Minami, I., Izumiyama, H., et al. (2016) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2015-000188 · Cited by 121 · see citing works
Depressive Symptoms and Increased Visceral Fat in Middle-Aged Women
Everson‐Rose, S. A., Lewis, T. T., Karavolos, K., Dugan, S. A., Wesley, D., & Powell, L. H. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a20c9c · Cited by 114 · see citing works
Bouchi, R., Nakano, Y., Fukuda, T., Takeuchi, T., Murakami, M., Minami, I., Izumiyama, H., Hashimoto, K., Yoshimoto, T., & Ogawa, Y. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej16-0449 · Cited by 113 · see citing works
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Lear, S. A., Humphries, K. H., Kohli, S., Frohlich, J. J., Birmingham, C. L., & Mancini, G. B. J. (2007) · Stroke · doi:10.1161/strokeaha.107.484113 · Cited by 111 · see citing works
Nagaretani, H., Nakamura, T., Funahashi, T., Kotani, K., Miyanaga, M., Tokunaga, K., Takahashi, M., Nishizawa, H., Kishida, K., Kuriyama, H., et al. (2001) · Diabetes Care · doi:10.2337/diacare.24.12.2127 · Cited by 109 · see citing works
“Hypertension 9 (17) 25 (32) 9 (56) 8 (29) 21 (29) 10 (43)”
BackgroundKanaya, A. M. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg271 · Cited by 105 · see citing works
Takami, R., Takeda, N., Hayashi, M., Sasaki, A., Kawachi, S.-I., Yoshino, K., Takami, K., Nakashima, K., Akai, A., Yamakita, N., et al. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1248 · Cited by 101 · see citing works
Bouchi, R., Takeuchi, T., Akihisa, M., Ohara, N., Nakano, Y., Nishitani, R., Murakami, M., Fukuda, T., Fujita, M., Minami, I., et al. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0302-4 · Cited by 99 · see citing works
“As shown in Table 1, S(−)V(+) patients were older than Background Obesity has been reported to be associated with insulin resistance, dyslipidemia, and hypertension, thus increasing the risk for cardiovascular disease (CVD) [1–4].”
BackgroundLitwin, S. E. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.017 · Cited by 98 · see citing works
Visceral adiposity as a target for the management of the metabolic syndrome
Kishida, K., Funahashi, T., Matsuzawa, Y., & Shimomura, I. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.564202 · Cited by 98 · see citing works
Disruption of Protein Kinase A in Mice Enhances Healthy Aging
Enns, L. C., Morton, J., Treuting, P. R., Emond, M. J., Wolf, N. S., McKnight, G. S., Rabinovitch, P. S., & Ladiges, W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005963 · Cited by 96 · see citing works
“diabetes and mortality from cardiovascular disease [24–28].”
Ladeiras‐Lopes, R., Sampaio, F., Bettencourt, N., Fontes‐Carvalho, R., Ferreira, N. D., Leite-Moreira, A. F., & Gama, V. (2016) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2016.09.010 · Cited by 96 · see citing works
Teramoto, T., Sasaki, J., Ueshima, H., Egusa, G., Kinoshita, M., Shimamoto, K., Daida, H., Biro, S., Hirobe, K., Funahashi, T., et al. (2008) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e580 · Cited by 95 · see citing works
Sonographic assessment of abdominal fat distribution in infancy
Holzhauer, S., Zwijsen, R. M. L., Jaddoe, V. W. V., Boehm, G., Moll, H. A., Mulder, P. G. H., Kleyburg-Linkers, V. A., Albert Hofman, D., & Witteman, J. C. M. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9368-1 · Cited by 91 · see citing works
“role of intraabdominal fat in metabolic and cardiovascular disease [2–5].”
Williams, P. T., & Feldman, D. E. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.10.024 · Cited by 90 · see citing works
Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
Uranga, R. M., Bruce‐Keller, A. J., Morrison, C. D., Fernandez‐Kim, S. O., Ebenezer, P. J., Zhang, L., Dasuri, K., & Keller, J. N. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06803.x · Cited by 87 · see citing works
“…a common feature of aging, and epidemiological evidence supports its role as a prominent risk factor for insulin resistance, diabetes, and mortality from atherosclerotic cardiovascular disease (Shimokata et al. 1989; Cefalu et al. 1995; Ferrannini et al. 1997; Lamarche 1998; Fujimoto et al. 1999).”
Backgroundden Boer, M. A. M., Voshol, P. J., der Elst, J. P. S.-V., Korsheninnikova, E., Ouwens, D. M., Kuipers, F., Havekes, L. M., & Romijn, J. A. (2006) · Endocrinology · doi:10.1210/en.2006-0417 · Cited by 85 · see citing works
Oppert, J., Charles, M.-A. A., Thibult, N., Guy-grand, B., Eschwège, É., & Ducimetière, P. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.6.1107 · Cited by 85 · see citing works
“In the one published prospective study, Fujimoto et al (31) reported that intraabdominal fat measured with computed tomography, but not abdominal subcutaneous fat, was associated with the 10-y incidence of coronary heart disease in Japanese TABLE 3 Correlations between anthropometric variables1 Arm + thigh Sagittal Tr…”
BackgroundInfluentialClément, S., Juge-Aubry, C. E., Sgroi, A., Conzelmann, S., Pazienza, V., Pittet-Cuenod, B. M., Meier, C. A., & Negro, F. (2008) · Hepatology · doi:10.1002/hep.22404 · Cited by 85 · see citing works
“, positive control; , negative control; (1) IL-6, (2) leptin, (3) MCP-1, (4) PARC, (5) PDGF-BB, (6) adiponectin, (7) GRO, (8) GRO , (9) hepatocyte growth factor (HGF), and (10) IL-8.”
Czernichow, S., Bruckert, E., Bertrais, S., Galan, P., Hercberg, S., & Oppert, J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803477 · Cited by 92 · see citing works
Liao, D., Asberry, P. J., Shofer, J. B., Callahan, H. S., Matthys, C. C., Boyko, E. J., Leonetti, D. L., Kahn, S. E., Austin, M. A., Newell, L., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1504 · Cited by 81 · see citing works
Self-citationO'Connor, M. Y., Thoreson, C. K., Ricks, M., Courville, A. B., Thomas, F., Yao, J., Katzmarzyk, P. T., & Sumner, A. E. (2014) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0026 · Cited by 80 · see citing works
Amelioration of diet-induced diabetes mellitus by removal of visceral fat
Pitombo, C. A., ARAUJO, E. P. D., de Souza, C. T., Pareja, J. C., Geloneze, B., & Velloso, L. A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.07069 · Cited by 78 · see citing works
Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors
Feliciano, E. M. C., Chen, W. Y., Bradshaw, P. T., Prado, C. M. M., Alexeeff, S., Albers, K. B., Castillo, A., & Caan, B. J. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.00286 · Cited by 79 · see citing works
Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?
Chen, P., Hou, X., Hu, G., Wei, L., Jiao, L., Wang, H., Chen, S., Wu, J., Bao, Y., & Jia, W. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0734-8 · Cited by 80 · see citing works
Type 2 diabetes and the metabolic syndrome in Japanese Americans
Fujimoto, W. Y., Bergstrom, R. W., Boyko, E. J., Chen, K.-W., Kahn, S. E., Leonetti, D. L., McNeely, M. J., Newell, L., Shofer, J. B., & WAHL, P. W. (2000) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00182-0 · Cited by 76 · see citing works
Self-citationMetabolic Syndrome Amplifies the LDL-Cholesterol Associated Increases in Carotid Atherosclerosis
Kawamoto, R., Tomita, H., Oka, Y., Kodama, A., & Kamitani, A. (2005) · Internal Medicine · doi:10.2169/internalmedicine.44.1232 · Cited by 76 · see citing works
Ding, J., Kritchevsky, S. B., Hsu, F., Harris, T. B., Burke, G. L., Detrano, R., Szklo, M., Criqui, M. H., Allison, M., Ouyang, P., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.645 · Cited by 75 · see citing works
Predicting Metabolic Syndrome in Obese Children and Adolescents: Look, Measure and Ask
Santoro, N., Amato, A., Grandone, A., et al. (2013) · Obesity Facts · doi:10.1159/000348625 · Cited by 72 · see citing works
Tong, J., Boyko, E., Utzschneider, K., McNeely, M., Hayashi, T., Carr, D. B., Wallace, T., Zraika, S., Gerchman, F., Leonetti, D., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0651-y · Cited by 71 · see citing works
Self-citationThe Utility of Physical Activity in the Management of Global Cardiometabolic Risk
Janiszewski, P. M., & Ross, R. (2009) · Obesity · doi:10.1038/oby.2009.382 · Cited by 71 · see citing works
Association of Visceral and Subcutaneous Adiposity with Kidney Function
Young, J. A., Hwang, S., Sarnak, M. J., Hoffmann, U., Massaro, J. M., Levy, D. A., Benjamin, E. J., Larson, M. G., Vasan, R. S., O’Donnell, C. J., et al. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02490508 · Cited by 71 · see citing works
Estimating Visceral Fat Area by Multifrequency Bioelectrical Impedance
Nagai, M., Komiya, H., Mori, Y., Ohta, T., Kasahara, Y., & Ikeda, Y. (2010) · Diabetes Care · doi:10.2337/dc09-1099 · Cited by 68 · see citing works
Ladeiras‐Lopes, R., Sampaio, F., Bettencourt, N., Fontes‐Carvalho, R., Ferreira, N. D., Leite-Moreira, A. F., & Gama, V. (2017) · Revista Española de Cardiología · doi:10.1016/j.recesp.2016.09.006 · Cited by 69 · see citing works
“Tabaquismo actual 113 (16) 16 (22) 97 (15) 0,151”
Koba, S., Hirano, T., Yoshino, G., Sakai, K., Sakaue, T., Adachi, M., & Katagiri, T. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00580-9 · Cited by 69 · see citing works
Mongraw‐Chaffin, M., Allison, M., Burke, G. L., Criqui, M. H., Matsushita, K., Ouyang, P., Shah, R. V., Shay, C. M., & Anderson, C. A. M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01113 · Cited by 66 · see citing works
“Similarly, there are two studies in participants of Japanese ancestry (4, 8) and, to our knowledge, none from a Hispanic cohort.”
BackgroundResultLee, Y., Lee, S., Jung, E. S., Kim, J., Shim, C. Y., Ko, Y., Choi, D., Jang, Y., Chung, N., & Ha, J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.09.012 · Cited by 65 · see citing works
Relationship between Waist Circumference, Body Mass Index, and Medical Care Costs
Cornier, M., Tate, C. W., Grunwald, G. K., & Bessesen, D. H. (2002) · Obesity Research · doi:10.1038/oby.2002.158 · Cited by 64 · see citing works
Depressive Mood and Abdominal Fat Distribution in Overweight Premenopausal Women
Lee, E. S., Kim, Y., Beck, S. H., Lee, S. Y., & Oh, S. W. (2005) · Obesity Research · doi:10.1038/oby.2005.43 · Cited by 61 · see citing works
Nishimoto, Y., & Tamori, Y. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17011 · Cited by 60 · see citing works
Visceral adipose tissue as a predictor for metabolic risk factors in the Korean population
Han, J. H., Park, H. S., Kim, S. M., Lee, S. Y., Kim, D. J., & Choi, W. H. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02317.x · Cited by 60 · see citing works
Hiuge-Shimizu, A., Kishida, K., Funahashi, T., Ishizaka, Y., Oka, R., Okada, M., Suzuki, S., Takaya, N., Nakagawa, T., Fukui, T., et al. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12963 · Cited by 59 · see citing works
Mapping body fat distribution: A key step towards the identification of the vulnerable patient?
Arsenault, B. J., Pelletier-Beaumont, É., Després, J., & Larose, É. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.605387 · Cited by 56 · see citing works
Risk Factors for Type 2 Diabetes: Lessons Learned from Japanese Americans in Seattle
Fujimoto, W., Boyko, E., Hayashi, T., Kahn, S., Leonetti, D., McNeely, M., & Shuman, W. (2012) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2012.00195.x · Cited by 62 · see citing works
Self-citationSasai, H., Brychta, R. J., Wood, R. P., Rothney, M. P., Zhao, X., Skarulis, M. C., & Chen, K. Y. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815577424 · Cited by 55 · see citing works
Self-citationYu, S., YARNELL, J. W. G., Sweetnam, P. M., & Bolton, C. H. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00361-1 · Cited by 55 · see citing works
“Fujimoto [21] conducted a prospective study in Seattle of 175 Japanese-American men without CHD who were followed for up to 10 years.”
Liao, D., Shofer, J. B., Boyko, E., McNeely, M., Leonetti, D., Kahn, S. E., & Fujimoto, W. Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.1.39 · Cited by 57 · see citing works
Self-citationGestational Diabetes or Lesser Degrees of Glucose Intolerance and Risk of Preeclampsia
Carr, D. B., Newton, K. M., Utzschneider, K. M., Faulenbach, M. V., Kahn, S. E., Easterling, T. R., & Heckbert, S. R. (2010) · Hypertension in Pregnancy · doi:10.3109/10641950903115012 · Cited by 53 · see citing works
“development of type 2 diabetes mellitus (35) and coronary heart disease (36).”
BackgroundSnell‐Bergeon, J. K., Hokanson, J. E., Kinney, G. L., Dabelea, D., Ehrlich, J., Eckel, R. H., Ogden, L. G., & Rewers, M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802796 · Cited by 52 · see citing works
Metabolic Syndrome in Pediatrics: Old Concepts Revised, New Concepts Discussed
D’Adamo, E., Santoro, N., & Caprio, S. (2011) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.07.005 · Cited by 51 · see citing works
- Authors
- Fujimoto, W. Y., Bergstrom, R. W., Boyko, E. J., Chen, K. W., Leonetti, D. L., Newell-Morris, L., Shofer, J. B., & Wahl, P. W.
- Affiliations
- University of Washington (US)
- Department of Medicine, University of Washington, Seattle 98195, USA. wilfuji@u.washington.edu
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1999-11-01
- Volume
- 22
- Issue
- 11
- Pages
- 1808-1812
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2105023507
- Cited by
- 296
- References
- 0
- Citations by year
- 2025: 2 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 16 · 2017: 12 · 2016: 17 · 2015: 8 · 2014: 11 · 2013: 14 · 2012: 17
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 49293, R01HL049293)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 31170)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- visceral fat, coronary artery disease, Japanese-American men, intra-abdominal fat, HDL cholesterol, HDL2, HDL3 cholesterol, triglycerides, fasting blood glucose, blood pressure, diabetes mellitus, cardiovascular risk factors
- MeSH terms
- Adipose Tissue, Coronary Disease, Follow-Up Studies, Humans, Japan, Male, Middle Aged, Viscera, Washington, Odds Ratio, Asian People
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