Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?
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In the present review, it is argued that while weight loss is associated with substantial reduction in obesity-related cardiovascular disease risk and remains a desired outcome of relevant treatment strategies, increasing physical activity is associated with marked reduction in waist circumference, visceral fat and cardiometabolic risk factors, concurrent with an increase in cardiorespiratory fitness despite minimal or no change in body weight. Failure to recognize the benefits of exercise independent of weight loss masks opportunities to counsel and educate patients whose sole criteria for gauging obesity reduction success is the bathroom scale.
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Exercise might reduce viral reactivation in lean, overweight and obese individuals by decreasing adiposity and maintaining redox balance, limiting accumulation of late-stage differentiated CMV-specific T cells.
“considering exercise decreases visceral and subcutaneous adiposity even in the absence of “weight loss” (Ross and Janiszewski 2008; Tchernof and Despres 2013), and exercise is a potent anti-inflammatory stimulus that helps maintain redox balance even in obesity (Farinha et al. 2015; Gleeson et al. 2011; Ji et al. 2006; Radak et al. 2008), then exercise might reduce viral reactivation in lean,”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Ross and Janiszewski 2008
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Changing the Endpoints for Determining Effective Obesity Management
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Self-citationRunning as Interoceptive Exposure for Decreasing Anxiety Sensitivity: Replication and Extension
Sabourin, B. C., Stewart, S. H., Watt, M. C., & Krigolson, O. E. (2015) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2015.1015163 · Cited by 40 · see citing works
- Authors
- Ross, R., & Janiszewski, P. M.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Ross, Robert
- Venue
- Canadian Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 24
- Pages
- 25D-31D
- ISSN
- 0828-282X (ISSN-L)
- PMC
- PMC2794451
- OpenAlex
- W2078672610
- Cited by
- 141
- References
- 86
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 13 · 2020: 4 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 12 · 2015: 18 · 2014: 13 · 2013: 9 · 2012: 7
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Cardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- obesity, weight loss, cardiovascular risk, physical activity, waist circumference, visceral fat, cardiometabolic risk factors, cardiorespiratory fitness, body weight
- MeSH terms
- Cardiovascular Diseases, Exercise Therapy, Humans, Morbidity, Obesity, Prognosis, Risk Factors, Global Health, Weight Loss
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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