Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell function.
Open accessAbstract
OBJECTIVE: A drastic difference is evident in the prevalence of type 2 diabetes among ethnic groups. We examined the role of beta-cell function and insulin sensitivity in this disparity among 4 ethnic groups. RESEARCH DESIGN AND METHODS: beta-Cell function and insulin sensitivity were assessed in 77 healthy glucose-tolerant subjects using a hyperglycemic clamp (18 Asian-Americans, 9 African-Americans, 34 Caucasians, and 16 Mexican-Americans). RESULTS: A wide range of variation was evident in clinical features of the studied subjects. Insulin sensitivity index and the second-phase insulin response differed among the 4 groups (P = 0.0023 and P = 0.0082, respectively), whereas the first-phase insulin response was marginally different (P = 0.1090). Stepwise regression analysis revealed that ethnicity was an independent determinant for the insulin sensitivity index (P = 0.0014) after adjusting for sex, age, diastolic blood pressure, waist-to-hip ratio, and BMI. Also, a compensatory response of beta-cell function was observed among the ethnic groups. CONCLUSIONS: In this study, we observed a drastic difference in insulin sensitivity among the different ethnic groups and observed that their beta-cell function compensates for the prevailing insulin sensitivity. The difference in the prevalence of abnormal glucose tolerance in different ethnic groups could be a result of differences in insulin sensitivity
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Type 2 diabetes mellitus is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility.
“Type 2 diabetes mellitus (T2DM) is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility.”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [7]
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- Authors
- Chiu, K. C., Cohan, P., Lee, N. P., & Chuang, L. M.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2000-09-01
- Volume
- 23
- Issue
- 9
- Pages
- 1353-1358
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2125626003
- Cited by
- 154
- References
- 28
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 2 · 2014: 7 · 2013: 12 · 2012: 6
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Action Research and Education Foundation
- Deutsches Krebsforschungszentrum
- National Institutes of Health (5r01dk052337-05)
- U.S. Public Health Service
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-52337-01)
- National Center for Research Resources (M01RR000865, MO1-RR-00865)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulin sensitivity, beta-cell function, ethnic differences, type 2 diabetes prevalence, second-phase insulin response, first-phase insulin response, insulin sensitivity index, Asian Americans, African Americans, Mexican Americans, Caucasians, glucose tolerance
- MeSH terms
- Insulin Secretion, Adult, Black or African American, Blood Glucose, Ethnicity, Female, Glucose Tolerance Test, Humans, Insulin, Islets of Langerhans, Male, Mexico, Regression Analysis, Los Angeles, Glucose Clamp Technique, Mexican Americans, Black People, White People, Asian People, Racial Groups
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