Postchallenge Hyperglycemia in a National Sample of U.S. Adults With Type 2 Diabetes
Open accessAbstract
OBJECTIVE—Postchallenge hyperglycemia (PCH) is known to contribute to suboptimal glycemic control in adults with non–insulin-requiring type 2 diabetes. The objective of this study was to estimate the prevalence of PCH among individuals with diabetes. RESEARCH DESIGN AND METHODS—We conducted a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (1988–1994) in adults aged 40–74 years with diabetes who were not using insulin (i.e., they used oral hypoglycemics or received no pharmacological therapy). Each respondent underwent a standard 75-g oral glucose tolerance test. PCH was defined as a 2-h glucose level ≥200 mg/dl. RESULTS—Overall, PCH was present in 74% of those with diagnosed diabetes. Although it was present in virtually all (99%) of the diabetic adults under suboptimal glycemic control (HbA1c ≥7.0%), PCH was also common (39%) among those under optimal control (HbA1c <7.0%). Likewise, among sulfonylurea users, PCH was present in 99% of those under suboptimal control and in 63% of those under good control. Similar patterns were observed in those with undiagnosed diabetes. Isolated PCH (2-h glucose ≥200 mg/dl and fasting glucose <126 mg/dl) was present in 9.8% of the adults with diagnosed diabetes. CONCLUSIONS—These data suggest that PCH is common among diabetic adults in the U.S., even in the setting of “optimal” glycemic control and sulfonylurea use. Interventions designed to lower postprandial glucose excursions may help improve overall glycemic control in the general population of U.S. adults with diabetes.
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These findings agree with NHANES data on post-OGTT hyperglycaemia in diabetic patients.
“These values are consistent with data on post-OGTT hyperglycaemia collected in diabetic patients from NHANES [18]”
From Prevalence and correlates of post-prandial hyperglycaemia in a large sample of patients with type 2 diabetes mellitus (2006) · cites this paper as [18]
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Yuan, L., Luo, Y., Luo, Y. L., Ding, B., Zhang, P., Ma, J., & Wu, J.-D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1364585
Postprandial glucose management of people with insulin-treated diabetes
McGill, J. B., Hirsch, I. B., Levy, C. J., Cengiz, E., Aleppo, G., & Carlson, A. L. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1947837
- Authors
- Erlinger, T. P., & Brancati, F. L.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Erlinger, Thomas P.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2001-10-01
- Volume
- 24
- Issue
- 10
- Pages
- 1734-1738
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2170897377
- Cited by
- 83
- References
- 27
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Update notices
- correction (2002-01-01)
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, glycemic control, HbA1c, sulfonylureas, oral antidiabetic drugs, oral glucose tolerance test, postprandial glucose excursions, undiagnosed diabetes, prevalence
- MeSH terms
- Adult, Aged, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Fasting, Food, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemic Agents, Kinetics, Middle Aged, Sulfonylurea Compounds
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