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Cited by 222Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Disease PreventionCardiovascular Function and Risk Factors

Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in non-diabetic individuals

Hanefeld, M·1999·Atherosclerosis
DOI 10.1016/s0021-9150(99)00059-3
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Abstract

Postprandial (pp) hyperglycemia--frequently associated with an increase in cardiovascular risk factors--may be damaging for the endothelium. So far, little information exists how glucose, insulin and lipids may affect atherosclerosis in the pp state. Therefore, we evaluated the relationship of pp hyperglycemia, insulin secretion and coronary risk factors to intima-media thickness (IMT) in a non-diabetic risk population. In 403 subjects (147 males, 256 females), aged 40-70 years, in the majority relatives of index cases with type 2 diabetes--a 75 g oral glucose tolerance test was performed together with measurement of insulin fractions, various risk factors and IMT of the common carotid artery. We found a continuous rise of 2h pp insulin fractions along the quintiles of 2h pp plasma glucose. A significant increase of body mass index, waist to hip ratio, triglycerides and decrease of HDL-cholesterol was observed in the top quintile of 2h pp plasma glucose (8.24 > or = pp plasma glucose < 11.1 mmol/l). Albuminuria was significantly enhanced in the 5th quintile. In parallel, IMT was significantly increased in the 5th quintile versus the bottom quintile of 2 h and maximal glucose (range 11.7-15.3 mmol/l) postprandially. After age and sex adjustment pp glucose and C-peptide, total cholesterol, triglycerides and HDL-cholesterol but not fasting plasma glucose were significantly correlated to IMT. In multivariate analysis age, male sex, pp plasma glucose, total and HDL-cholesterol were found to be independent risk factors for increased IMT. In conclusion, our data in a non-diabetic European risk population show that the two top quintiles of pp plasma glucose are associated with a clustering of standard risk factors. Corresponding to this clustering of risk factors IMT was significantly increased in the top quintile of 2 h and maximal pp plasma glucose. These data show that pp hyperglycemia may exert a noxious impact on the arterial wall together with a cluster of anomalies typical for the metabolic syndrome.

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Authors
Hanefeld, M.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1999-05
Volume
144
Issue
1
Pages
229-235
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/s0021-9150(99)00059-3
OpenAlex
W2015382104
Cited by
222
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 13
FWCI
4.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
postprandial hyperglycemia, carotid intima-media thickness, insulin secretion, C-peptide, metabolic syndrome, cardiovascular risk factors, non-diabetic adults, HDL cholesterol, triglycerides, albuminuria, endothelial injury
MeSH terms
Adult, Aged, Analysis of Variance, Blood Glucose, Carotid Arteries, Coronary Disease, Diabetes Mellitus, Female, Glucose Tolerance Test, Health Surveys, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Ultrasonography, Comorbidity, Confidence Intervals, Tunica Intima, Risk Assessment, Statistics, Nonparametric, Postprandial Period

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