The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Homeostasis Model Assessment Is a Reliable Indicator of Insulin Resistance During Follow-up of Patients With Type 2 Diabetes
Abstract
OBJECTIVE— To investigate the usefulness of the homeostasis model assessment as an index of insulin resistance (HOMA-IR) for evaluating the clinical course of patients with type 2 diabetes. RESEARCH DESIGN AND METHODS— The usefulness of HOMA-IR and its relationship with insulin resistance assessed by the hyperinsulinemic-euglycemic clamp study (clamp IR) were evaluated in 55 Japanese patients with type 2 diabetes before and after treatment. The patients were subjected to diet (∼1,440-1,720 kcal/day) and exercise therapy (walking 10,000 steps daily) for 6 weeks during their hospitalization. RESULTS— Univariate regression analysis disclosed a significant correlation between log-transformed HOMA-IR and log-transformed clamp IR before (r = -0.613, P < 0.0001) and after(r = -0.734, P < 0.0001) treatment. Neither the slopes(-0.71 ± 0.12 vs. -0.79 ± 0.09, F = 0.25, P =0.61) nor the intercepts (y-intercept = 1.67 vs. 1.70, x-intercept = 2.36 vs. 2.15, F = 0.02, P = 0.88) of the regression lines between HOMA-IR and clamp IR were significantly different before and after treatment. There was a significant correlation between the decrease in log-transformed HOMA-IR and the increase in clamp IR during treatment (r = -0.617, P < 0.0001). CONCLUSIONS— HOMA-IR may constitute a useful method not only for diagnosing insulin resistance, but also for follow-up during the treatment of patients with type 2 diabetes.
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Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program
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Use and Abuse of HOMA Modeling
Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114
The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus
Kadoglou, N. P. E., Iliadis, F., Angelopoulou, N., Perrea, D., Ampatzidis, G., Liapis, C. D., & Alevizos, M. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282efaf50 · Cited by 337
The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes
Bergman, R. N., Finegood, D. T., & Kahn, S. E. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.5.x · Cited by 301
Evaluation of insulin sensitivity in clinical practice and in research settings
Monzillo, L. U., & Hamdy, O. (2003) · Nutrition Reviews · doi:10.1301/nr.2003.dec.397-412 · Cited by 259
Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in Wistar rats
Antunes, L. C., Elkfury, J. L., Jornada, M. N., Foletto, K. C., & Bertoluci, M. C. (2016) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000169 · Cited by 247
Metadata
- Authors
- Katsuki, A., Sumida, Y., Gabazza, E. C., Murashima, S., Furuta, M., Araki-Sasaki, R., Hori, Y., Yano, Y., & Adachi, Y.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2001-02-01
- Volume
- 24
- Issue
- 2
- Pages
- 362-365
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2142470321
- Cited by
- 431
- References
- 29
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Katsuki, A., Sumida, Y., Gabazza, E. C., Murashima, S., Furuta, M., Araki-Sasaki, R., Hori, Y., Yano, Y., & Adachi, Y. (2001). Homeostasis Model Assessment Is a Reliable Indicator of Insulin Resistance During Follow-up of Patients With Type 2 Diabetes. Diabetes Care. https://doi.org/10.2337/diacare.24.2.362
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