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Cited by 276

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High Prevalence of Hypovitaminosis D in Female Type 2 Diabetic Population

Isaia, Giancarlo, Giorgino, Ruben, Adami, Silvano·2001·Diabetes Care

Abstract

Animal studies have demonstrated lower levels of 1,25(OH)2D3 in a type 2 diabetes model compared with controls (1). Alterations in circulating vitamin D3 metabolites, such as decreased 1α-hydroxylase activity and enhanced renal 25-hydroxylase activity, have been found in both experimental and human diabetes. These alterations in vitamin D metabolism may be associated with the deranged mineral homeostasis and skeletal morphology observed in rats and people with chronic insulin deficiency (2). Experimentally, vitamin D deficiency progressively reduces insulin secretion, and this reduction soon becomes irreversible (3). It was also shown that insulin deficiency may be associated with lower vitamin D–binding …

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Metadata

Authors
Isaia, G., Giorgino, R., & Adami, S.
Venue
Diabetes Care
Published
2001-08-01
Volume
24
Issue
8
Pages
1496-1496
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
OpenAlex
W2108144028
Cited by
276
References
0
FWCI
1.04
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.