Cited by 358Coffee research and impactsDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

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Caffeine Can Decrease Insulin Sensitivity in Humans

Keijzers, Gerben B., De Galan, Bastiaan E., Tack, Cees J., Smits, Paul·2002·Diabetes Care

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Abstract

Objective Caffeine is a central stimulant that increases the release of catecholamines. As a component of popular beverages, caffeine is widely used around the world. Its pharmacological effects are predominantly due to adenosine receptor antagonism and include release of catecholamines. We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake. Research design and methods Hyperinsulinemic-euglycemic glucose clamps were used to assess insulin sensitivity. Caffeine or placebo was administered intravenously to 12 healthy volunteers in a randomized, double-blind, crossover design. Measurements included plasma levels of insulin, catecholamines, free fatty acids (FFAs), and hemodynamic parameters. Insulin sensitivity was calculated as whole-body glucose uptake corrected for the insulin concentration. In a second study, the adenosine reuptake inhibitor dipyridamole was tested using an identical protocol in 10 healthy subjects. Results Caffeine decreased insulin sensitivity by 15% (P Conclusions Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels. Because dipyridamole did not affect glucose uptake, peripheral adenosine receptor antagonism does not appear to contribute to this effect.

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“Using the euglycemic clamp technique, Deibert and DeFronzo (9) showed that epinephrine infusion reduced tissue sensitivity to insulin by 50%.”
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Authors: Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P.
Affiliations: Department of Internal Medicine, University Medical Center, Nijmegen, the Netherlands
ORCID: Keijzers, Gerben B.
De Galan, Bastiaan E.
Tack, Cees J.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2002-02-01
Volume: 25
Issue: 2
Pages: 364-369
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.25.2.364
OpenAlex: W2112839007
Cited by: 358
References: 42
Citations by year: 2026: 8 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 17 · 2014: 19 · 2013: 23 · 2012: 20
FWCI: 10.64
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: European Commission
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: caffeine, insulin sensitivity, insulin resistance, catecholamines, epinephrine, norepinephrine, adenosine receptor antagonism, dipyridamole, free fatty acids, glucose uptake, hyperinsulinemic-euglycemic clamp, blood pressure
MeSH terms: Adult, Central Nervous System Stimulants, Caffeine, Dipyridamole, Double-Blind Method, Epinephrine, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Male, Norepinephrine, Phosphodiesterase Inhibitors, Glucose Clamp Technique

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Caffeine Can Decrease Insulin Sensitivity in Humans

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