CoChat
Sign Up
Cited by 358Coffee research and impactsDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Caffeine Can Decrease Insulin Sensitivity in Humans

Keijzers, Gerben B., De Galan, Bastiaan E., Tack, Cees J., Smits, Paul·2002·Diabetes Care
DOI 10.2337/diacare.25.2.364
Open this paper in CoChat — free account

Abstract

Objective Caffeine is a central stimulant that increases the release of catecholamines. As a component of popular beverages, caffeine is widely used around the world. Its pharmacological effects are predominantly due to adenosine receptor antagonism and include release of catecholamines. We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake. Research design and methods Hyperinsulinemic-euglycemic glucose clamps were used to assess insulin sensitivity. Caffeine or placebo was administered intravenously to 12 healthy volunteers in a randomized, double-blind, crossover design. Measurements included plasma levels of insulin, catecholamines, free fatty acids (FFAs), and hemodynamic parameters. Insulin sensitivity was calculated as whole-body glucose uptake corrected for the insulin concentration. In a second study, the adenosine reuptake inhibitor dipyridamole was tested using an identical protocol in 10 healthy subjects. Results Caffeine decreased insulin sensitivity by 15% (P Conclusions Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels. Because dipyridamole did not affect glucose uptake, peripheral adenosine receptor antagonism does not appear to contribute to this effect.

Overview

Integrity signals

Registry

Crossref · 10.2337/diacare.25.2.364

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 42 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P.
Affiliations
Department of Internal Medicine, University Medical Center, Nijmegen, the Netherlands
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2002-02-01
Volume
25
Issue
2
Pages
364-369
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.25.2.364
OpenAlex
W2112839007
Cited by
358
References
42
Citations by year
2026: 8 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 17 · 2014: 19 · 2013: 23 · 2012: 20
FWCI
10.64
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
European Commission
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
caffeine, insulin sensitivity, insulin resistance, catecholamines, epinephrine, norepinephrine, adenosine receptor antagonism, dipyridamole, free fatty acids, glucose uptake, hyperinsulinemic-euglycemic clamp, blood pressure
MeSH terms
Adult, Central Nervous System Stimulants, Caffeine, Dipyridamole, Double-Blind Method, Epinephrine, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Male, Norepinephrine, Phosphodiesterase Inhibitors, Glucose Clamp Technique

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review