The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Caffeine Can Decrease Insulin Sensitivity in Humans
Abstract
Objective Caffeine is a central stimulant that increases the release of catecholamines. As a component of popular beverages, caffeine is widely used around the world. Its pharmacological effects are predominantly due to adenosine receptor antagonism and include release of catecholamines. We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake. Research design and methods Hyperinsulinemic-euglycemic glucose clamps were used to assess insulin sensitivity. Caffeine or placebo was administered intravenously to 12 healthy volunteers in a randomized, double-blind, crossover design. Measurements included plasma levels of insulin, catecholamines, free fatty acids (FFAs), and hemodynamic parameters. Insulin sensitivity was calculated as whole-body glucose uptake corrected for the insulin concentration. In a second study, the adenosine reuptake inhibitor dipyridamole was tested using an identical protocol in 10 healthy subjects. Results Caffeine decreased insulin sensitivity by 15% (P Conclusions Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels. Because dipyridamole did not affect glucose uptake, peripheral adenosine receptor antagonism does not appear to contribute to this effect.
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“Moreover, caffeine is known to acutely decrease insulin sensitivity in human subjects (Graham et al. 2000;Keijzers et al. 2002).”
From Glycaemic index methodology (2005) · cites this paper as Keijzers et al. 2002
Citations
Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
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Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
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Epinephrine-induced insulin resistance in man
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“Using the euglycemic clamp technique, Deibert and DeFronzo (9) showed that epinephrine infusion reduced tissue sensitivity to insulin by 50%.”
Tolerance to the humoral and hemodynamic effects of caffeine in man.
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“Chronic use of caffeine (and related methylxanthine derivatives) is known to result in attenuation of both humoral and pressor effects that are associated with acute ingestion (37), perhaps due to upregulation of adenosine receptors (38).”
On the Mechanism of Action of Theophylline and Caffeine
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Coffee and Health: A Review of Recent Human Research
Higdon, J. V., & Frei, B. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390500400009 · Cited by 1,090
Brouns, F., Bjorck, I., Frayn, K. N., Gibbs, A. L., Lang, V., Slama, G., & Wolever, T. M. S. (2005) · Nutrition Research Reviews · doi:10.1079/nrr2005100 · Cited by 1,093
Curriculum, K. (2006) · Cited by 768
Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review
van Dam, R. M., & Hu, F. B. (2005) · JAMA · doi:10.1001/jama.294.1.97 · Cited by 662
Coffee and its Consumption: Benefits and Risks
Butt, M. S., & Sultan, M. T. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903586412 · Cited by 631
Metadata
- Authors
- Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P.
- Affiliations
- Department of Internal Medicine, University Medical Center, Nijmegen, the Netherlands
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-02-01
- Volume
- 25
- Issue
- 2
- Pages
- 364-369
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2112839007
- Cited by
- 358
- References
- 42
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 17 · 2014: 19 · 2013: 23 · 2012: 20
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- caffeine, insulin sensitivity, insulin resistance, catecholamines, epinephrine, norepinephrine, adenosine receptor antagonism, dipyridamole, free fatty acids, glucose uptake, hyperinsulinemic-euglycemic clamp, blood pressure
- MeSH terms
- Adult, Central Nervous System Stimulants, Caffeine, Dipyridamole, Double-Blind Method, Epinephrine, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Male, Norepinephrine, Phosphodiesterase Inhibitors, Glucose Clamp Technique
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