The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Comparison of Insulin Aspart With Buffered Regular Insulin and Insulin Lispro in Continuous Subcutaneous Insulin Infusion
Abstract
Objective To compare the safety and efficacy of insulin aspart (IAsp), buffered regular insulin (BR), and insulin lispro administered by continuous subcutaneous insulin infusion (CSII) in patients with type 1 diabetes. Research design and methods After completing a 4-week run-in period with BR, 146 adult patients with type 1 diabetes (with pretrial CSII experience) were randomly assigned (2:2:1) to CSII treatment with IAsp, BR, or lispro for 16 weeks in a multicenter, open-label, randomized, parallel-group study. Bolus insulin doses were administered 30 min before meals (BR) or immediately before meals (IAsp or lispro). Results Treatment groups had similar baseline HbA(1c) (7.3% +/- 0.7 for IAsp, 7.5% +/- 0.8 for BR, and 7.3% +/- 0.7 for lispro). After 16 weeks of treatment, HbA1c values were relatively unchanged from baseline, and the mean changes in baseline HbA1c values were not significantly different between the three groups (0.00 +/- 0.51, 0.15 +/- 0.63, and 0.18 +/- 0.84 for the IAsp, BR, and lispro groups, respectively). The rates of hypoglycemic episodes (blood glucose Conclusions Insulin aspart in CSII was as efficacious and well tolerated as BR and lispro and is a suitable insulin for continuous subcutaneous insulin infusion using external pumps.
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“In one of the earliest studies of the frequency of insulin pump occlusion, reported in 2001, over a 24-week period, approximately 66% (38 of 58) subjects with type 1 diabetes using an insulin pump had an episode of hyperglycemia and 36% of the episodes were caused by an occlusion of the IIS.”
From Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block (2017) · cites this paper as [6]
In the citing paper
“There was no significant difference in the occlusion rate when these patients used either insulin lispro (LIS) or buffered regular insulin (BRI).6”
From Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block (2017) · cites this paper as [6]
In the citing paper
“In one of the earliest studies of the frequency of insulin pump occlusion, reported in 2001, over a 24-week period, approximately 66% (38 of 58) subjects with type 1 diabetes using an insulin pump had an episode of hyperglycemia and 36% of the episodes were caused by an occlusion of the IIS.”
From Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block (2017) · cites this paper as [6]
Citations
Cites
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Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus.
Siebenhofer, A., Plank, J., Berghold, A., Jeitler, K., Horvath, K., Narath, M., Gfrerer, R., & Pieber, T. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003287.pub4 · Cited by 283
Raskin, P., Bode, B. W., Marks, J. B., Hirsch, I. B., Weinstein, R. L., McGill, J. B., Peterson, G. E., Mudaliar, S. R., & Reinhardt, R. R. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2598 · Cited by 248
Self-citationClinical and cost-effectiveness of continuous subcutaneous insulin infusion for diabetes
Colquitt, J. L., Green, C., Sidhu, M. S., Hartwell, D., & Waugh, N. (2004) · Health Technology Assessment · doi:10.3310/hta8430 · Cited by 249
Insulin analogues in type 1 diabetes mellitus: Getting better all the time
Mathieu, C., Gillard, P., & Benhalima, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.39 · Cited by 248
Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis
Singh, S. R., Ahmad, F., Lal, A., Yu, C., Bai, Z., & Bennett, H. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.081041 · Cited by 241
Metadata
- Authors
- Bode, B., Weinstein, R., Bell, D., McGill, J., Nadeau, D., Raskin, P., Davidson, J., Henry, R., Huang, W.-C., & Reinhardt, R. R.
- Affiliations
- Atlanta Diabetes Associates (US)
- Diablo Clinical Research (US)
- Kirklin Clinic (US)
- Washington University in St. Louis (US)
- Eastern Maine Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Endocrine & Diabetes Associates, Dallas, Texas
- VA San Diego Healthcare System (US)
- Novo Nordisk Pharmaceuticals, Princeton, New Jersey
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-03-01
- Volume
- 25
- Issue
- 3
- Pages
- 439-444
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2091336973
- Cited by
- 148
- References
- 26
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2020: 3 · 2018: 5 · 2017: 6 · 2016: 1 · 2015: 7 · 2014: 6 · 2013: 10 · 2012: 6
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- insulin aspart, insulin lispro, insulin pump therapy, type 1 diabetes, bolus insulin, glycemic control, HbA1c, hypoglycemia, insulin analogues
- MeSH terms
- Adult, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Male, Safety, Body Mass Index, Insulin Aspart, Insulin Lispro
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