Are Lower Fasting Plasma Glucose Levels at Diagnosis of Type 2 Diabetes Associated With Improved Outcomes?
Abstract
OBJECTIVE—Type 2 diabetes may be present for several years before diagnosis, by which time many patients have already developed diabetic complications. Earlier detection and treatment may reduce this burden, but evidence to support this approach is lacking. RESEARCH DESIGN AND METHODS—Glycemic control and clinical and surrogate outcomes were compared for 5,088 of 5,102 U.K. Diabetes Prospective Study participants according to whether they had low (<140 mg/dl [<7.8 mmol/l]), intermediate (140 to <180 mg/dl [7.8 to <10.0 mmol/l]), or high (≥180 mg/dl [≥10 mmol/l]) fasting plasma glucose (FPG) levels at diagnosis. Individuals who presented with and without diabetic symptoms were also compared. RESULTS—Fewer people with FPG in the lowest category had retinopathy, abnormal biothesiometer measurements, or reported erectile dysfunction. The rate of increase in FPG and HbA1c during the study was identical in all three groups, although absolute differences persisted. Individuals in the low FPG group had a significantly reduced risk for each predefined clinical outcome except stroke, whereas those in the intermediate group had significantly reduced risk for each outcome except stroke and myocardial infarction. The low and intermediate FPG groups had a significantly reduced risk for progression of retinopathy, reduction in vibration sensory threshold, or development of microalbuminuria. CONCLUSIONS—People presenting with type 2 diabetes with lower initial glycemia who may be earlier in the course of their disease had fewer adverse clinical outcomes despite similar glycemic progression. Since most such people are asymptomatic at diagnosis, active case detection programs would be required to identify them.
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Lower levels of glycemia at the time of initial therapy are associated with lower A1C levels over time and decreased long-term complications.
“Lower levels of glycemia at the time of initial therapy are associated with lower A1C levels over time and decreased long-term complications (38).”
From Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy (2009) · cites this paper as [38]
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- Authors
- Colagiuri, S., Cull, C. A., Holman, R. R., & For the UKPDS Group
- Affiliations
- University of Oxford (GB)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-08-01
- Volume
- 25
- Issue
- 8
- Pages
- 1410-1417
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W1989258316
- Cited by
- 183
- References
- 19
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 10
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, fasting blood glucose, asymptomatic diabetes, early diagnosis, glycemic control, retinopathy, diabetic neuropathy, microalbuminuria, erectile dysfunction, stroke, myocardial infarction, HbA1c, disease progression, active case finding
- MeSH terms
- Aged, Blood Glucose, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Fasting, Female, Glycated Hemoglobin, Humans, Hyperglycemia, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Treatment Outcome, Disease-Free Survival
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