Cited by 734Nitric Oxide and Endothelin EffectsAdvanced Glycation End Products researchAntioxidant Activity and Oxidative Stress

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New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

Ceriello, Antonio·2003·Diabetes Care

DOI 10.2337/diacare.26.5.1589

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Abstract

Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic complications. However, intervention studies with classic antioxidants, such as vitamin E, failed to demonstrate any beneficial effect. Recent studies demonstrate that a single hyperglycemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain seems to be the first and key event in the activation of all other pathways involved in the pathogenesis of diabetic complications. These include increased polyol pathway flux, increased advanced glycosylation end product formation, activation of protein kinase C, and increased hexosamine pathway flux. Superoxide overproduction is accompanied by increased nitric oxide generation, due to an endothelial NOS and inducible NOS uncoupled state, a phenomenon favoring the formation of the strong oxidant peroxynitrite, which in turn damages DNA. DNA damage is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP-ribose) polymerase. Poly(ADP-ribose) polymerase activation in turn depletes the intracellular concentration of its substrate NAD+, slowing the rate of glycolysis, electron transport, and ATP formation, and produces an ADP-ribosylation of the GAPDH. These processes result in acute endothelial dysfunction in diabetic blood vessels that, convincingly, also contributes to the development of diabetic complications. These new findings may explain why classic antioxidants, such as vitamin E, which work by scavenging already-formed toxic oxidation products, have failed to show beneficial effects on diabetic complications and may suggest new and attractive “causal” antioxidant therapy. New low–molecular mass compounds that act as SOD or catalase mimetics or l-propionyl-carnitine and lipoic acid, which work as intracellular superoxide scavengers, improving mitochondrial function and reducing DNA damage, may be good candidates for such a strategy, and preliminary studies support this hypothesis. This “causal” therapy would also be associated with other promising tools such as LY 333531, PJ34, and FP15, which block the protein kinase β isoform, poly(ADP-ribose) polymerase, and peroxynitrite, respectively. While waiting for these focused tools, we may have other options: thiazolinediones, statins, ACE inhibitors, and angiotensin 1 inhibitors can reduce intracellular oxidative stress generation, and it has been suggested that many of their beneficial effects, even in diabetic patients, are due to this property.

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The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)09327-3 · Cited by 6,992
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277

Show all 102 references

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Faheem, N. M., & Askary, A. E. (2017) · PubMed Central · doi:10.22038/ijbms.2017.8839 · Cited by 31
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Jiao, D., Zhang, H., Jiang, Z., Huang, W., Liu, Z., Wang, Z., Wang, Y., & Wu, H. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1667-0 · Cited by 32
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Miranda, M., Muriach, M., Almansa, I., Arnal, E., Messeguer, Á., Díaz-Llopis, M., Romero, F. J., & Bosch‐Morell, F. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.001 · Cited by 31
High glucose concentrations per se do not adversely affect human sperm function in vitro
Portela, J. M. D., Tavares, R. S., Mota, P. C., Ramalho‐Santos, J., & Amaral, S. (2015) · Reproduction · doi:10.1530/rep-15-0100 · Cited by 31
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Elmi, S., Sallam, N. A., Rahman, M. M., Teng, X., Hunter, A. L., Moien‐Afshari, F., Khazaei, M., Granville, D. J., & Laher, I. (2007) · Vascular Pharmacology · doi:10.1016/j.vph.2007.09.001 · Cited by 31
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Khong, F. L., Zhang, Y., Edgley, A. J., Qi, W., Connelly, K. A., Woodman, O. L., Krum, H., & Kelly, D. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022777 · Cited by 30
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Authors: Ceriello, A.
Affiliations: University of Udine (IT)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2003-05-01
Volume: 26
Issue: 5
Pages: 1589-1596
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.26.5.1589
OpenAlex: W2058550328
Cited by: 734
References: 102
Citations by year: 2026: 9 · 2025: 8 · 2024: 16 · 2023: 15 · 2022: 16 · 2021: 24 · 2020: 13 · 2019: 27 · 2018: 34 · 2017: 41 · 2016: 33 · 2015: 34 · 2014: 46 · 2013: 49 · 2012: 50
FWCI: 4.48
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, diabetes complications, superoxide, mitochondrial electron transport chain, hyperglycemia, polyol pathway, advanced glycation end products, protein kinase C, hexosamine biosynthetic pathway, nitric oxide, peroxynitrite, DNA damage, poly(ADP-ribose) polymerase, NAD+ depletion, endothelial dysfunction, antioxidant therapy, superoxide dismutase mimetic, catalase mimetics, alpha-lipoic acid, PJ34, thiazolidinediones, statins, ACE inhibitors, angiotensin receptor blockers
MeSH terms: Antioxidants, Diabetes Mellitus, DNA Damage, Endothelium, Vascular, Humans, Hyperglycemia, Models, Biological, Oxidative Stress, Peroxynitrous Acid, Diabetes Complications

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New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

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