Cited by 734Nitric Oxide and Endothelin EffectsAdvanced Glycation End Products researchAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

Ceriello, Antonio·2003·Diabetes Care

DOI 10.2337/diacare.26.5.1589

Open this paper in CoChat — free account

Abstract

Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic complications. However, intervention studies with classic antioxidants, such as vitamin E, failed to demonstrate any beneficial effect. Recent studies demonstrate that a single hyperglycemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain seems to be the first and key event in the activation of all other pathways involved in the pathogenesis of diabetic complications. These include increased polyol pathway flux, increased advanced glycosylation end product formation, activation of protein kinase C, and increased hexosamine pathway flux. Superoxide overproduction is accompanied by increased nitric oxide generation, due to an endothelial NOS and inducible NOS uncoupled state, a phenomenon favoring the formation of the strong oxidant peroxynitrite, which in turn damages DNA. DNA damage is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP-ribose) polymerase. Poly(ADP-ribose) polymerase activation in turn depletes the intracellular concentration of its substrate NAD+, slowing the rate of glycolysis, electron transport, and ATP formation, and produces an ADP-ribosylation of the GAPDH. These processes result in acute endothelial dysfunction in diabetic blood vessels that, convincingly, also contributes to the development of diabetic complications. These new findings may explain why classic antioxidants, such as vitamin E, which work by scavenging already-formed toxic oxidation products, have failed to show beneficial effects on diabetic complications and may suggest new and attractive “causal” antioxidant therapy. New low–molecular mass compounds that act as SOD or catalase mimetics or l-propionyl-carnitine and lipoic acid, which work as intracellular superoxide scavengers, improving mitochondrial function and reducing DNA damage, may be good candidates for such a strategy, and preliminary studies support this hypothesis. This “causal” therapy would also be associated with other promising tools such as LY 333531, PJ34, and FP15, which block the protein kinase β isoform, poly(ADP-ribose) polymerase, and peroxynitrite, respectively. While waiting for these focused tools, we may have other options: thiazolinediones, statins, ACE inhibitors, and angiotensin 1 inhibitors can reduce intracellular oxidative stress generation, and it has been suggested that many of their beneficial effects, even in diabetic patients, are due to this property.

Integrity signals

Registry

Crossref · 10.2337/diacare.26.5.1589

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)09327-3 · Cited by 6,992
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277

Show all 102 references

Sorted by citations

Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378
Self-citation
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Rolo, A. P., & Palmeira, C. M. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.003 · Cited by 1,007
Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice
Johansen, J. S., Harris, A. K., Rychly, D. J., & Ergul, A. (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-5 · Cited by 1,024
Postprandial Hyperglycemia and Diabetes Complications
Ceriello, A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.1 · Cited by 945
Self-citation
Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities
Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742
Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus
Meigs, J. B. (2004) · JAMA · doi:10.1001/jama.291.16.1978 · Cited by 643
The Molecular Basis for Oxidative Stress-Induced Insulin Resistance
Evans, J. L., Maddux, B. A., & Goldfine, I. D. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1040 · Cited by 587
The Role of Oxidative Stress in Diabetic Complications
Niedowicz, D. M., & Daleke, D. L. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:2:289 · Cited by 533
The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy
Barber, A. J., Gardner, T. W., & Abcouwer, S. F. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6293 · Cited by 446
The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?
Ceriello, A., Ihnat, M. A., & Thorpe, J. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1824 · Cited by 420
Self-citation
Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
Yan, L. (2014) · Journal of Diabetes Research · doi:10.1155/2014/137919 · Cited by 425
Antioxidant and free radical scavenging potential of Achillea santolina extracts
Ardestani, A. D., & Yazdanparast, R. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.10.066 · Cited by 391
In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits
Bakırel, T., Bakırel, U., Üstüner, O., Ülgen, S., & Yardibi, H. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.10.039 · Cited by 390
Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice
BarathManiKanth, S., Kalishwaralal, K., Sriram, M. I., Pandian, S. R. K., Youn, H., Eom, S.-H., & Gurunathan, S. (2010) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-8-16 · Cited by 392
Lipid Peroxidation in Diabetes Mellitus
Davı̀, G., Falco, A., & Patrono, C. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.256 · Cited by 378
Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment
Ceriello, A., Quagliaro, L., Piconi, L., Assaloni, R., Da Ros, R., Maier, A., Esposito, K., & Giugliano, D. (2004) · Diabetes · doi:10.2337/diabetes.53.3.701 · Cited by 362
Self-citation
Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
Kitada, M., Kume, S., Imaizumi, N., & Koya, D. (2011) · Diabetes · doi:10.2337/db10-0386 · Cited by 345
Evaluation of a New Measure of Blood Glucose Variability in Diabetes
Kovatchev, B. P., Otto, E., Cox, D. J., Gonder-Frederick, L. A., & Clarke, W. L. (2006) · Diabetes Care · doi:10.2337/dc06-1085 · Cited by 344
Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes
Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2022) · Molecules · doi:10.3390/molecules27030950 · Cited by 354
Role of Nitrosative Stress and Peroxynitrite in the Pathogenesis of Diabetic Complications. Emerging New Therapeutical Strategies
Pacher, P., Obrosova, I. G., Mabley, J. G., & Szabó, C. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053363207 · Cited by 335
Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction
Piconi, L., Quagliaro, L., Assaloni, R., ROS, R. D., Maier, A., Zuodar, G., & Ceriello, A. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.613 · Cited by 332
Self-citation
Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
Madsen‐Bouterse, S. A., & Kowluru, R. A. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9090-4 · Cited by 307
Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients
Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298
Self-citation
The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions
Bensellam, M., Laybutt, D. R., & Jonas, J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.08.003 · Cited by 304
Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species
Ramalho-Santos, J., Amaral, S., & Oliveira, P. (2008) · Current Diabetes Reviews · doi:10.2174/157339908783502398 · Cited by 359
Oxidative Stress in Diabetes
Piconi, L., Quagliaro, L., & Ceriello, A. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.177 · Cited by 256
Self-citation
Advanced glycation endproducts (AGEs): pharmacological inhibition in diabetes
Peyroux, J., & Sternberg, M. (2006) · Pathologie Biologie · doi:10.1016/j.patbio.2006.07.006 · Cited by 250
Curcumin-induced inhibition of cellular reactive oxygen species generation: Novel therapeutic implications
Balasubramanyam, M., Koteswari, A. A., Kumar, R. S., Monickaraj, S. F., Maheswari, J. U., & Mohan, V. (2003) · Journal of Biosciences · doi:10.1007/bf02708432 · Cited by 243
Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes
Patel, T. P., Rawal, K., Bagchi, A. K., Akolkar, G., Bernardes, N., Dias, D. D. S., Gupta, S. S., & Singal, P. K. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9515-6 · Cited by 243
Nitrosative stress and pharmacological modulation of heart failure
Pacher, P., Schulz, R., Liaudet, L., & Szabó, C. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.003 · Cited by 237
Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis
Carlström, M., & Larsson, S. C. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy014 · Cited by 248
Diabetic nephropathy: Is there a role for oxidative stress?
Sagoo, M. K., & Gnudi, L. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.040 · Cited by 237
The Keap1-Nrf2 system and diabetes mellitus
Uruno, A., Yagishita, Y., & Yamamoto, M. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.12.012 · Cited by 231
Possible role of oxidative stress in the pathogenesis of hypertension
Ceriello, A. (2008) · Diabetes Care · doi:10.2337/dc08-s245 · Cited by 215
Self-citation
Therapeutic Applications of Rose Hips from Different Rosa Species
Mármol, I., Sánchez‐de‐Diego, C., Jiménez‐Moreno, N., Ancín‐Azpilicueta, C., & Rodriguez‐Yoldi, M. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061137 · Cited by 221
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2‐deficient mice
Yoh, K., Hirayama, A., Ishizaki, K., Yamada, A., Takeuchi, M., Yamagishi, S., Morito, N., Nakano, T., Ojima, M., Shimohata, H., et al. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01234.x · Cited by 207
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Matzinger, M., Fischhuber, K., & Heiß, E. H. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.015 · Cited by 208
Chronic Kidney Disease Influences Multiple Systems: Describing the Relationship between Oxidative Stress, Inflammation, Kidney Damage, and Concomitant Disease
Tucker, P. S., Scanlan, A. T., & Dalbo, V. J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/806358 · Cited by 208
Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy
Cai, L., Wang, J., Li, Y., Sun, X., Wang, L., Zhou, Z., & Kang, Y. J. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1829 · Cited by 199
Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis
Nishikawa, M., Hashida, M., & Takakura, Y. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.01.001 · Cited by 200
Intervention against the Maillard reaction in vivo
Monnier, V. M. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.014 · Cited by 196
Diabetic nephropathy and antioxidants
Tavafi, M. (2013) · Journal of Nephropathology · doi:10.5812/nephropathol.9093 · Cited by 195
Antioxidant Anti-Inflammatory Treatment in Type 2 Diabetes
Ceriello, A., & Testa, R. (2009) · Diabetes Care · doi:10.2337/dc09-s316 · Cited by 200
Self-citation
Effect of NCB-02, Atorvastatin and Placebo on Endothelial Function, Oxidative Stress and Inflammatory Markers in Patients with Type 2 Diabetes Mellitus
Usharani, P., Mateen, A., Naidu, M. U. R., Raju, Y. S. N., & Chandra, N. (2008) · Drugs in R&D · doi:10.2165/00126839-200809040-00004 · Cited by 200
Mitochondria, Synaptic Plasticity, And Schizophrenia
Ben‐Shachar, D., & Laifenfeld, D. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59011-6 · Cited by 191
Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease: A Systematic Review of Randomised Controlled Trials
Clarke, R., Dordevic, A. L., Tan, S. M., Ryan, L., & Coughlan, M. T. (2016) · Nutrients · doi:10.3390/nu8030125 · Cited by 186
Role of Poly(ADP-Ribose) Polymerase-1 Activation in the Pathogenesis of Diabetic Complications: Endothelial Dysfunction, as a Common Underlying Theme
Pacher, P., & Szabó, C. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1568 · Cited by 183
Postprandial hyperglycemia as an etiological factor in vascular failure
Node, K., & Inoue, T. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-23 · Cited by 183
The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy
Sifuentes-Franco, S., Pacheco-Moisés, F. P., Rodríguez-Carrizález, A. D., & Miranda‐Díaz, A. G. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1673081 · Cited by 186
Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease
Houghton, C. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2716870 · Cited by 191
Mild hypoglycemia is independently associated with increased mortality in the critically ill
Krinsley, J. S., Schultz, M. J., Spronk, P. E., Harmsen, R. E., Houckgeest, F. V. B., van der Sluijs, J. P., Mélot, C., & Preiser, J. (2011) · Critical Care · doi:10.1186/cc10322 · Cited by 181
Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes
Pacher, P., & Szabó, C. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.01.001 · Cited by 177
The emerging challenge in diabetes: The “metabolic memory”
Ceriello, A. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.05.005 · Cited by 177
Self-citation
Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction
Mehta, J. L., Rasouli, N., Sinha, A. K., & Molavi, B. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.12.008 · Cited by 169
Hypothesis: the ‘metabolic memory’, the new challenge of diabetes
Ihnat, M. A., Thorpe, J. E., & Ceriello, A. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02138.x · Cited by 169
Self-citation
Postprandial glucose regulation: New data andnew implications
Leiter, L. A., Ceriello, A., Davidson, J. A., Hanefeld, M., Monnier, L., Owens, D. R., Tajima, N., & Tuomilehto, J. O. (2005) · Clinical Therapeutics · doi:10.1016/j.clinthera.2005.11.020 · Cited by 160
Self-citation
α-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2−.-generation
Wenzel, U., Nickel, A. G., & Daniel, H. (2005) · APOPTOSIS · doi:10.1007/s10495-005-0810-x · Cited by 159
Attenuation of Angiotensin II Signaling Recouples eNOS and Inhibits Nonendothelial NOX Activity in Diabetic Mice
Oak, J., & Cai, H. “. (2006) · Diabetes · doi:10.2337/db06-0288 · Cited by 157
Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update
Ceriello, A., Davidson, J., Hanefeld, M., Leiter, L. A., Monnier, L., Owens, D. R., Tajima, N., & Tuomilehto, J. O. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.006 · Cited by 155
Self-citation
Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy
Kasznicki, J., Kosmalski, M., Śliwińska, A., Mrowicka, M., Stańczyk, M. B., Majsterek, I., & Drzewoski, J. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1722-9 · Cited by 146
The research and development on the antioxidants in prevention of diabetic complications
Rahimi‐Madiseh, M., Malekpour-Tehrani, A., Bahmani, M., & Rafieian‐Kopaei, M. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.07.001 · Cited by 145
Erythritol is a sweet antioxidant
den Hartog, G. J. M., Boots, A. W., Adam‐Perrot, A., Brouns, F. J. P. H., Verkooijen, I., Weseler, A. R., Haenen, G. R. M. M., & Bast, A. (2009) · Nutrition · doi:10.1016/j.nut.2009.05.004 · Cited by 140
Hypoglycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L’Hér. in alloxan induced diabetic rats
Boukhris, M., Bouaziz, M. A., Feki, I., Jemai, H., Feki, A. E., & Sayadi, S. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-81 · Cited by 138
Regular Physical Exercise as a Strategy to Improve Antioxidant and Anti-Inflammatory Status: Benefits in Type 2 Diabetes Mellitus
Teixeira‐Lemos, E., de Oliveira, J. B. F., Pinheiro, J. P., & Reis, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/741545 · Cited by 136
High Glucose Blunts Vascular Endothelial Growth Factor Response to Hypoxia via the Oxidative Stress-Regulated Hypoxia-Inducible Factor/Hypoxia-Responsible Element Pathway
Katavetin, P., Miyata, T., Inagi, R., Tanaka, T., Sassa, R., Ingelfinger, J. R., Fujita, T., & Nangaku, M. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005090918 · Cited by 135
Rapid ‘glycaemic swings’ induce nitrosative stress, activate poly(ADP-ribose) polymerase and impair endothelial function in a rat model of diabetes mellitus
Horvath, E. M., Benkő, R., Kiss, L., Murányi, M., Pék, T., Fekete, K., Bárány, T., Somlai, Á., Csordás, A., & Szabó, C. (2009) · Diabetologia · doi:10.1007/s00125-009-1304-0 · Cited by 132
Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?
Basha, B. M., Samuel, S. M., Triggle, C. R., & Ding, H. (2012) · Experimental Diabetes Research · doi:10.1155/2012/481840 · Cited by 131
Oxidative Stress and Antioxidant Defense Mechanisms Linked to Exercise During Cardiopulmonary and Metabolic Disorders
Fisher‐Wellman, K. H., Bell, H. K., & Bloomer, R. J. (2008) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.1.7732 · Cited by 131
The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications
Fenercioğlu, A. K., Saler, T., Genç, E., Sabuncu, H., & Altuntaş, Y. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346565 · Cited by 130
Platelets Express Activated P2Y 12 Receptor in Patients With Diabetes Mellitus
Hu, L., Chang, L., Zhang, Y., Zhai, L., Zhang, S., Qi, Z., Yan, H., Yan, Y., Luo, X., Zhang, S., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026995 · Cited by 134
Protective effects of Annona muricata linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats
Adewole, S. O., & Ojewole, J. A. O. (2010) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v6i1.57071 · Cited by 135
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
Son, S. M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.3.190 · Cited by 125
The role of nitric oxide in inflammation and oxidative stress
Papi, S., Ahmadizar, F., & Hasanvand, A. (2019) · Immunopathologia Persa · doi:10.15171/ipp.2019.08 · Cited by 126
Late Stage Complications of Diabetes and Insulin Resistance
Soumya, D., & Srilatha, B. (2011) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000167 · Cited by 123
Role of oxidative stress in diabetes-mediated vascular dysfunction: Unifying hypothesis of diabetes revisited
Schaffer, S. W., Jong, C. J., & Mozaffari, M. S. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.03.005 · Cited by 125
Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway
Duan, J., Guan, Y., Mu, F., Guo, C., Zhang, E., Yin, Y., Wei, G., Zhu, Y., Cui, J., Cao, J., et al. (2017) · Scientific Reports · doi:10.1038/srep41491 · Cited by 124
Impaired glucose tolerance and cardiovascular disease: the possible role of post-prandial hyperglycemia
Ceriello, A. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.11.020 · Cited by 124
Self-citation
Blood pressure lowering and anti‐inflammatory effects of hesperidin in type 2 diabetes; a randomized double‐blind controlled clinical trial
Homayouni, F., Haidari, F., Hedayati, M., Zakerkish, M., & Angali, K. A. (2018) · Phytotherapy Research · doi:10.1002/ptr.6046 · Cited by 126
Hypothesis: the “metabolic memory”, the new challenge of diabetes
Ceriello, A. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(09)70002-6 · Cited by 120
Self-citation
Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus
Zemestani, M., Rafraf, M., & Jafarabadi, M. A. (2015) · Nutrition · doi:10.1016/j.nut.2015.07.011 · Cited by 115
Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function
Nicolson, G. L., & Ash, M. E. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.11.010 · Cited by 117
Curcumin attenuates oxidative stress induced NFκB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes
Rashid, K., Chowdhury, S., Ghosh, S., & Sil, P. C. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.009 · Cited by 115
The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial
Atkin, M., Laight, D. W., & Cummings, M. H. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.003 · Cited by 115
Pyridoxamine Traps Intermediates in Lipid Peroxidation Reactions in Vivo
Metz, T., Alderson, N. L., Chachich, M. E., Thorpe, S. R., & Baynes, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304292200 · Cited by 112
Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats
de Morais, H., de Souza, C. P., da Silva, L. M., Ferreira, D. M., Werner, M. F., Andreatini, R., da Cunha, J. M., & Zanoveli, J. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.011 · Cited by 111
Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status
Chen, J., Zhang, Z., & Cai, L. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.5.337 · Cited by 112
Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Venkatachalam, K., Mummidi, S., Cortez, D. M., Prabhu, S. D., Valente, A. J., & Chandrasekar, B. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01363.2007 · Cited by 112
Clinical review: Oxygen as a signaling molecule
Bartz, R. R., & Piantadosi, C. A. (2010) · Critical Care · doi:10.1186/cc9185 · Cited by 116
Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain ofdb/dbmice: role of AMP-activated protein kinase activation
Zheng, A., Li, H., Xu, J., Cao, K. J., Li, H., Pu, W., Yang, Z., Peng, Y., Long, J., Liu, J., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000884 · Cited by 108
Clinical implications of oxidative stress and potential role of natural antioxidants in diabetic vascular complications
Ceriello, A., Testa, R., & Genovese, S. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.01.006 · Cited by 106
Self-citation
Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function
Nicolson, G. L. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21247 · Cited by 108
Simultaneous Control of Hyperglycemia and Oxidative Stress Normalizes Endothelial Function in Type 1 Diabetes
Ceriello, A., Kumar, S., Piconi, L., Esposito, K., & Giugliano, D. (2007) · Diabetes Care · doi:10.2337/dc06-2048 · Cited by 105
Self-citation
Type 1 diabetes and cardiovascular disease
Schnell, O., Cappuccio, F. P., Genovese, S., Standl, E., Valensi, P. E., & Ceriello, A. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-156 · Cited by 110
Self-citation
Structural changes in the myocardium during diabetes-induced cardiomyopathy
Adeghate, E. A., & Singh, J. (2013) · Heart Failure Reviews · doi:10.1007/s10741-013-9388-5 · Cited by 104
Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells
Tsuneki, H., Sekizaki, N., Suzuki, T., Kobayashi, S., Wada, T., Okamoto, T., Kimura, I., & Sasaoka, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.006 · Cited by 104
Urinary Markers of Nucleic Acid Oxidation and Long-Term Mortality of Newly Diagnosed Type 2 Diabetic Patients
Broedbaek, K., Siersma, V., Henriksen, T., Weimann, A., Petersen, M. A., Andersen, J. T., Jimenez‐Solem, E., Stovgaard, E. S., Hansen, L. J., Henriksen, J. E., et al. (2011) · Diabetes Care · doi:10.2337/dc11-1620 · Cited by 104
Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes
Panigrahy, S. K., Bhatt, R., & Kumar, A. (2017) · Journal of Drug Targeting · doi:10.1080/1061186x.2016.1207650 · Cited by 103
N-acetylcysteine attenuates PKCβ2overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats
Xia, Z., Kuo, K., Nagareddy, P. R., Wang, F., Guo, Z., Guo, T., Jiang, J., & McNeill, J. H. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.033 · Cited by 102
Variability in HbA1c , blood pressure, lipid parameters and serum uric acid, and risk of development of chronic kidney disease in type 2 diabetes
Ceriello, A., Cosmo, S. D., Rossi, M. C., Lucisano, G., Genovese, S., Pontremoli, R., Fioretto, P., Giorda, C. B., Pacilli, A., Viazzi, F. C., et al. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12976 · Cited by 100
Self-citation

Authors: Ceriello, A.
Affiliations: University of Udine (IT)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2003-05-01
Volume: 26
Issue: 5
Pages: 1589-1596
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.26.5.1589
OpenAlex: W2058550328
Cited by: 734
References: 102
Citations by year: 2026: 9 · 2025: 8 · 2024: 16 · 2023: 15 · 2022: 16 · 2021: 24 · 2020: 13 · 2019: 27 · 2018: 34 · 2017: 41 · 2016: 33 · 2015: 34 · 2014: 46 · 2013: 49 · 2012: 50
FWCI: 4.48
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, diabetes complications, superoxide, mitochondrial electron transport chain, hyperglycemia, polyol pathway, advanced glycation end products, protein kinase C, hexosamine biosynthetic pathway, nitric oxide, peroxynitrite, DNA damage, poly(ADP-ribose) polymerase, NAD+ depletion, endothelial dysfunction, antioxidant therapy, superoxide dismutase mimetic, catalase mimetics, alpha-lipoic acid, PJ34, thiazolidinediones, statins, ACE inhibitors, angiotensin receptor blockers
MeSH terms: Antioxidants, Diabetes Mellitus, DNA Damage, Endothelium, Vascular, Humans, Hyperglycemia, Models, Biological, Oxidative Stress, Peroxynitrous Acid, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks