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Effect of Weight Loss on Cardiac Synchronization and Proinflammatory Cytokines in Premenopausal Obese Women
Open accessAbstract
OBJECTIVE—Obesity is an important risk factor for heart failure in both women and men. Dyssynchrony between right and left ventricular contraction and relaxation has been identified as an independent predictor of heart failure. We examined the relationship of ventricular synchronization abnormalities with the concentration of proinflammatory cytokines in obese women at baseline and after sustained weight loss. RESEARCH DESIGN AND METHODS—Echocardiographic parameters of ventricular dyssynchrony, circulating levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-18, and C-reactive protein (CRP) were investigated in 67 healthy, premenopausal obese women and 40 age-matched normal-weight women. RESULTS—Compared with nonobese women, obese women had increased concentrations of CRP (P < 0.01), TNF-α (P < 0.01), IL-6 (P < 0.01), and IL-18 (P < 0.01). Moreover, obese women had a higher myocardial performance index (P < 0.02) and lower transmitral Doppler flow (P < 0.05), pulmonary venous flow analysis (P < 0.02), and ejection fraction (P < 0.05), indicating ventricular dyssynchrony. Concentrations of CRP, TNF-α, and IL-6 were related to anthropometric indexes of obesity and to echocardiographic parameters of ventricular dyssynchrony. After 1 year of a multidisciplinary program of weight reduction, obese women lost at least 10% of their original weight. This was associated with reduction of cytokine (P < 0.01) and CRP (P < 0.02) concentrations and with improvement of echocardiographic parameters of ventricular dyssynchrony, which correlated with changes in adiposity, particularly visceral adiposity. CONCLUSIONS—In obese women, ventricular dyssynchrony correlates with body fat, possibly through inappropriate secretion of cytokines. Weight loss represents a safe method for downregulating the inflammatory state and ameliorating cardiac function in obese women.
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Metadata
- Authors
- Marfella, R., Esposito, K., Siniscalchi, M., Cacciapuoti, F., Giugliano, F., Labriola, D., Ciotola, M., Di Palo, C., Misso, L., & Giugliano, D.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2004-01-01
- Volume
- 27
- Issue
- 1
- Pages
- 47-52
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2139321163
- Cited by
- 170
- References
- 35
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- obesity, weight loss, ventricular dyssynchrony, cardiac synchronization, inflammatory cytokines, TNF-α, interleukin-6, IL-18, C-reactive protein, premenopausal women, heart failure risk, myocardial performance index, pulmonary venous flow, ejection fraction, visceral fat, cardiac function
- MeSH terms
- Adult, Anthropometry, Female, Humans, Inflammation, Mitral Valve, Obesity, Reference Values, Weight Loss, Interleukin-6, Cytokines, Interleukin-8, Ventricular Function, Premenopause
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