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Cited by 237Cardiac Fibrosis and RemodelingHeart Failure Treatment and ManagementTransplantation: Methods and Outcomes

Circulating concentrations of proinflammatory cytolcines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

Munger, Mark A., Johnson, Barbara, Amber, Ina J., Callahan, Karleen S., Gilbert, Edward M.·1996·The American Journal of Cardiology
DOI 10.1016/s0002-9149(97)89206-5
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Abstract

Proinflammatory cytokines are capable of modulating cardiovascular function by a variety of mechanisms. These cytokines are elevated in patients with severe heart failure, but changes in mild or moderate heart failure have not been reported. Therefore, simultaneous arterial and coronary sinus concentrations of interleukin-1alpha, soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha were measured in 78 patients with New York Heart Association functional class II to IV heart failure and compared with 17 healthy volunteers. Concentrations of interleukin-1alpha, soluble interleukin-2 receptor, and interleukin-6 were determined by a "sandwich" enzyme-linked immunosorbent assay and tumor necrosis factor-alpha by tissue culture technique. There were no statistical differences in interleukin-1alpha, soluble interleukin-2 receptor, or tumor necrosis factor-alpha concentrations in mild to moderate heart failure versus control subjects. Interleukin-6 was significantly elevated, 75 +/- 16 versus 0.4 +/- 0.4pg/ml (p = 0.002). Cytokine concentrations did not differ by heart failure etiology. Paired arterial and coronary sinus concentrations were not significantly different. Soluble interleukin-2 receptor concentrations were significantly correlated with New York Heart Association functional class (r = 0.59, p = 0.04) and negatively associated with exercise tolerance time (r = -0.59, p = 0.007). Thus, interleukin-6 is significantly elevated in mild or moderate heart failure.

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  • Patients with heart failure have alterations in intestinal integrity, and elevated levels of pro-inflammatory cytokines in the blood correlate with symptom severity and poorer outcomes.

    “Multiple studies show patients with heart failure have alterations in intestinal integrity, and that elevated levels of pro-inflammatory cytokines in the blood correlate with symptom severity and poorer outcomes20, 21.”

    From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [20]

  • Intestinal absorption of endotoxin is a significant stimulus for systemic increases in inflammatory cytokines during heart failure.

    “There is evidence that the intestinal absorption of endotoxin is a significant stimulus for systemic increases in inflammatory cytokines during heart failure41,42.”

    From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [41]

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Authors
Munger, M. A., Johnson, B., Amber, I. J., Callahan, K. S., & Gilbert, E. M.
Affiliations
University of Utah (US)
Corresponding author
Gilbert, Edward M.
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1996-04
Volume
77
Issue
9
Pages
723-727
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(97)89206-5
OpenAlex
W2162460000
Cited by
237
References
21
Citations by year
2026: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 7
FWCI
8.10
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords
heart failure, inflammatory cytokines, interleukin-6, interleukin-1 alpha, soluble interleukin-2 receptor, TNF-α, dilated cardiomyopathy, ischemic cardiomyopathy, NYHA functional class, exercise tolerance
MeSH terms
Adrenergic alpha-Agonists, Arteries, Cardiac Output, Low, Cardiomyopathy, Dilated, Coronary Vessels, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interleukin-1, Male, Middle Aged, Norepinephrine, Stroke Volume, Tumor Necrosis Factor-alpha, Receptors, Interleukin-2, Interleukin-6, Cytokines, Ventricular Function, Left, Exercise Tolerance, Myocardial Ischemia, Inflammation Mediators

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