Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease
Abstract
Epidemiological studies suggest that physically active individuals have a 30–50% lower risk of developing type 2 diabetes than do sedentary persons and that physical activity confers a similar risk reduction for coronary heart disease. Risk reductions are observed with as little as 30 min of moderate-intensity activity per day. Protective mechanisms of physical activity include the regulation of body weight; the reduction of insulin resistance, hypertension, atherogenic dyslipidemia, and inflammation; and the enhancement of insulin sensitivity, glycemic control, and fibrinolytic and endothelial function. Public health initiatives promoting moderate increases in physical activity may offer the best balance between efficacy and feasibility to improve metabolic and cardiovascular health in largely sedentary populations.
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Moderate physical activity has several physiologic benefits that could reduce the incidence of atrial fibrillation in older adults.
“Moderate physical activity has several physiologic benefits that could reduce the incidence of AF in older adults.27–30”
From Physical Activity and Incidence of Atrial Fibrillation in Older Adults: The Cardiovascular Health Study (2008) · cites this paper as [29]
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Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
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Exercise, Vascular Wall and Cardiovascular Diseases: An Update (Part 1)
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“Both epidemiological and clinical trial data support the recommendation of 30 min of moderate-vigorous intensity exercise on most days of the week [54,55].”
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Self-citationAdiposopathy: treating pathogenic adipose tissue to reduce cardiovascular disease risk
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- Authors
- Bassuk, S. S., & Manson, J. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-09
- Volume
- 99
- Issue
- 3
- Pages
- 1193-1204
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2110185122
- Cited by
- 744
- References
- 116
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 14 · 2023: 29 · 2022: 25 · 2021: 31 · 2020: 28 · 2019: 36 · 2018: 37 · 2017: 26 · 2016: 44 · 2015: 34 · 2014: 53 · 2013: 52 · 2012: 49
- FWCI
- 23.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- physical activity, type 2 diabetes, cardiovascular disease, coronary artery disease, sedentary behavior, insulin resistance, insulin sensitivity, glycemic control, hypertension, dyslipidemia, inflammation, endothelial function, fibrinolysis, body weight regulation, public health promotion
- MeSH terms
- Clinical Trials as Topic, Coronary Disease, Diabetes Mellitus, Type 2, Exercise Therapy, Humans, Motor Activity, Prognosis, Risk Factors, Comorbidity, Treatment Outcome, Risk Assessment, Evidence-Based Medicine
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