Influence of Caffeine on Heart Rate Variability in Patients With Long-Standing Type 1 Diabetes
Open accessAbstract
OBJECTIVE—The effect of caffeine on cardiovascular health remains controversial. Patients with long-standing type 1 diabetes are at risk of autonomic failure and sudden cardiac death. We investigated the effects of caffeine on autonomic dysfunction (as assessed by heart rate variability [HRV]) in this high-risk group and in a control population. RESEARCH DESIGN AND METHODS—Using a randomized blinded, placebo-controlled, crossover design trial, we examined 2 weeks of caffeine consumption (250 mg twice daily) on HRV in 20 type 1 diabetic patients and 10 matched healthy volunteers. RESULTS—Baseline HRV was blunted in the diabetic patients (P < 0.0005 vs. control subjects) and markedly increased by caffeine in both groups (+103% in the group with diabetes [P = 0.009] and +38% in control subjects [P = 0.002]). The caffeine-associated increase in HRV was not statistically different between the control and the type 1 diabetes groups (P = 0.16). CONCLUSIONS—Modest amounts of caffeine improved autonomic function in diabetic patients and healthy volunteers. For individuals with abnormal HRV, regular caffeine use may have the potential to reduce the risk of cardiovascular events.
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The influence of caffeine on post-exercise autonomic recovery remains unclear.
“The effects of caffeine on autonomic function have been studied at rest and during exercise; 14,35 however, the influence of caffeine on post-exercise autonomic recovery remains unclear.”
From Caffeine delays autonomic recovery following acute exercise (2015) · cites this paper as [35]
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- Authors
- Richardson, T., Rozkovec, A., Thomas, P., Ryder, J., Meckes, C., & Kerr, D.
- Affiliations
- Royal Bournemouth Hospital (GB)
- Bournemouth University (GB)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2004-05-01
- Volume
- 27
- Issue
- 5
- Pages
- 1127-1131
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2154998641
- Cited by
- 55
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- caffeine, heart rate variability, type 1 diabetes, autonomic dysfunction, autonomic failure, sudden cardiac death, cardiovascular risk, long-standing diabetes, autonomic function
- MeSH terms
- Adult, Blood Pressure, Caffeine, Coffee, Diabetes Mellitus, Type 1, Female, Heart Rate, Glycated Hemoglobin, Humans, Male, Middle Aged, Reference Values, Cross-Over Studies
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